Results 61 to 70 of about 106,495 (294)

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Transient Local Bone Remodeling Effects of rhBMP-2 in an Ovine Interbody Spine Fusion Model [PDF]

, 2016
Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a powerful osteoinductive morphogen capable of stimulating the migration of mesenchymal stem cells (MSCs) to the site of implantation and inducing the proliferation and ...
Badura, Jeffrey, Bae, Hyun W., Patel, Vikas V., Pradhan, Ben B., Sardar, Zeeshan M., Seim, Howard, Toth, Jeffrey M., Turner, Anthony S.   +7 more
core   +1 more source

Start, Stop, Rewind, Repeat—Cyclic Exposure of Adipose Stromal Cells‐derived Cartilage Organoids to Chondrogenic and Proliferative Cues to Achieve Scaled‐up and Customizable Bone Formation by Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
This study exploits the plasticity of ASCs‐derived cartilage organoids which generate a perichondrial layer of MSCs when exposed to cyclic chondrogenic/proliferative cues. Using these organoids as building blocks, we develop (i) Phalange Shaped Tissue Engineered Cartilage (Pa‐TECs), recapitulating endochondral ossification suitable for the treatment of
Pablo Pfister, Emilien Lhospice, Andrés García‐García, Robert Paillaud, Sebastian Jung, Romain Schaller, Elisabeth A. Kappos, Claude Jaquiéry, Tarek Ismail, Dirk J. Schaefer, Michael de Wild, Ivan Martin, Alexandre Kaempfen, Arnaud Scherberich, Adrien Moya   +14 more
wiley   +1 more source

USE MORPHOGENETIC PROTEIN WITHIN SURGICAL TREATMENT OF RADICULAR CYSTS

В мире научных открытий, 2017
Comparative analysis of the treatment of radicular cysts by using a combination of osteoconductive and osteoinductive materials for filling postoperative defect had been performed.
Tatyana Leonidovna Marugina, Pavel Vladimirovich Bozhenenko, Kirill Pavlovich Аnikin, Aleksandr Aleksandrovich Venikov   +3 more
doaj   +1 more source

Micropatterning biomineralization with immobilized mother of pearl proteins

Scientific Reports, 2021
In response to the drawbacks of autograft donor-site morbidity and bone morphogenetic protein type 2 (BMP2) carcinogenesis and ectopic bone formation, there has been an increased research focus towards developing alternatives capable of achieving spatial
Kristopher A. White, Vincent J. Cali, Ronke M. Olabisi   +2 more
doaj   +1 more source

Bone-Forming Peptide-4 Induces Osteogenic Differentiation and VEGF Expression on Multipotent Bone Marrow Stromal Cells

Frontiers in Bioengineering and Biotechnology, 2021
Bone morphogenetic proteins (BMPs) have been widely used as treatment for bone repair. However, clinical trials on fracture repair have challenged the effectiveness of BMPs and suggested that delivery of multipotent bone marrow stromal cells (BMSCs ...
Mi Eun Kim, Jong Keun Seon, Jong Keun Seon, Ju Yeon Kang, Ju Yeon Kang, Taek Rim Yoon, Taek Rim Yoon, Jun Sik Lee, Hyung Keun Kim, Hyung Keun Kim   +9 more
doaj   +1 more source

Noggin depletion in adipocytes promotes obesity in mice. [PDF]

, 2019
ObjectiveObesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin ...
Blázquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guo, Yina, Jumabay, Medet, Lusis, Aldons J, Rajbhandari, Prashant, Reue, Karen, Sallam, Tamer, Tontonoz, Peter, Vergnes, Laurent, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng, Zhang, Li   +14 more
core   +1 more source

The Use of Bone Morphogenetic Protein in the Intervertebral Disk Space in Minimally Invasive Transforaminal Lumbar Interbody Fusion [PDF]

, 2019
Study Design: Retrospective Cohort. Objective: The objective of this study was to characterize one surgeon’s experience over a 10-year period using rhBMP-2 in the disk space for minimally invasive transforaminal lumbar interbody fusion (MIS TLIF ...
Anderson, Annis, Cahill, Carragee, Chen, Crandall, Djurasovic, Fan, Foley, Fu, Funao, Gianaris, Gu, Haid, Hoffmann, Hu, Kelly, Khan, Khan, Kim, McGirt, Phan, Phan, Rihn, Rihn, Sawchuk, Singh, Spitz, Wang   +28 more
core   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source