Results 1 to 10 of about 190,949 (143)

Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619

Cells, 2021
Osteosarcoma (OS) is the most common malignant bone tumor in children and teenagers. In many cases, such as poor response to treatment or the presence of metastases at diagnosis, the survival rate of patients remains very low. Although in the literature,
Mélanie Lavaud, Mathilde Mullard, Robel Tesfaye, Jérôme Amiaud, Mélanie Legrand, Geoffroy Danieau, Régis Brion, Sarah Morice, Laura Regnier, Maryne Dupuy, Bénédicte Brounais-Le Royer, François Lamoureux, Benjamin Ory, Françoise Rédini, Franck Verrecchia   +14 more
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LIM Kinases in Osteosarcoma Development

Cells, 2021
Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research
Régis Brion, Laura Regnier, Mathilde Mullard, Jérome Amiaud, Françoise Rédini, Franck Verrecchia   +5 more
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Pro-inflammatory effects of human apatite crystals extracted from patients suffering from calcific tendinopathy

Arthritis Research & Therapy, 2021
Background Calcific tendonitis of the rotator cuff is due to carbonated apatite deposits in the shoulder tendons. During the evolution of the disease, an acute inflammatory episode may occur leading to the disappearance of the calcification.
Julien Herman, Benoit Le Goff, Julien De Lima, Régis Brion, Catherine Chevalier, Frédéric Blanchard, Christelle Darrieutort-Laffite   +6 more
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Bone Remodeling

Annals of the New York Academy of Sciences, 2006
Abstract:  The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. Bone remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix through the osteoblasts that subsequently become mineralized.
Hadjidakis, D.J., Androulakis, I.I.
openaire   +5 more sources

Advances of exosomes in periodontitis treatment

Journal of Translational Medicine, 2022
Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone
Hongbing Lin, Huishan Chen, Xuetao Zhao, Tong Ding, Yawei Wang, Zhen Chen, Yue Tian, Peipei Zhang, Yuqin Shen   +8 more
doaj   +1 more source

Implication of the p53-Related miR-34c, -125b, and -203 in the Osteoblastic Differentiation and the Malignant Transformation of Bone Sarcomas

Cells, 2020
The formation of the skeleton occurs throughout the lives of vertebrates and is achieved through the balanced activities of two kinds of specialized bone cells: the bone-forming osteoblasts and the bone-resorbing osteoclasts. Impairment in the remodeling
Camille Jacques, Robel Tesfaye, Melanie Lavaud, Steven Georges, Marc Baud’huin, François Lamoureux, Benjamin Ory   +6 more
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Synthesis and Characterization of a Hydroxyapatite-Sodium Alginate-Chitosan Scaffold for Bone Regeneration

Frontiers in Materials, 2021
Bone scaffolds play an important role in promoting the healing of large bone defects. However, the type of scaffold material, type of drug loaded into the scaffold, and method of preparation have a significant impact on the scaffold's properties. In this
Dingkun Liu, Dingkun Liu, Zhihui Liu, Jundong Zou, Lingfeng Li, Xin Sui, Bizhou Wang, Nan Yang, Bowei Wang   +8 more
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Effects of chronic stress caused by occlusal disorder on the body

口腔疾病防治, 2020
Occlusal disorder is an abnormal condition in which the static and dynamic relations between the upper and lower teeth are not well aligned . The most common occlusal disorder in clinical practice is the inability to reach the intercuspal position due to
JIANG Jiayang, LI Baosheng, LI Yuyang, ZHANG Huiyan, JIN Zhuohua, OU Yanzhen, MENG Weiyan   +6 more
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Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro

Scientific Reports, 2021
In bone regeneration induced by the combination of mesenchymal stromal cells (MSCs) and calcium-phosphate (CaP) materials, osteoclasts emerge as a pivotal cell linking inflammation and bone formation.
Paul Humbert, Meadhbh Á. Brennan, Julien De Lima, Régis Brion, Annie Adrait, Céline Charrier, Bénédicte Brulin, Valérie Trichet, Yohann Couté, Frédéric Blanchard, Pierre Layrolle   +10 more
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The impact of masticatory dysfunction caused by occlusal disharmony on cognitive function

口腔疾病防治, 2021
As the world’s population ages, age-related cognitive decline and dementia are becoming important challenges for geriatric care. Despite the ongoing search for solutions to address cognitive decline, effective interventions have not yet been established.
OU Yanzhen, LI Baosheng, CAI Qing, JIANG Jiayang, JIN Zhuohua, MENG Weiyan   +5 more
doaj   +1 more source