Results 121 to 130 of about 798 (156)

Fluorination of p-Boronophenylalanine

2001
Using tumor-seeking property of p-Boronophenylalanine (BPA), BPA was fluorinated with 18F, and 18F-p-10B-BPA has been used for positron emission tomography (PET).1 But, chemical and biological properties of the 18F-10B-BPA are not completely understood. There are following merits for synthesis of 19F-BPA.
Kazuo Yoshino, Yoshiro Inamoto, Tatsuo Ido, Hidetake Kakihana, Masamitsu Ichihashi, Yutaka Mishima   +5 more
openaire   +1 more source

Synthesis of o- and m-Boronophenylalanine

1993
p-Boronophenylalanine (p-BPA) has been used for Boron Neutron Capture Therapy (BNCT). The synthetic route to p-BPA was developed by Snyder et al. 1. o- and m-Boronophenylalanine (o- and m-BPA) are the isomers of p-BPA, and they may be incorporated into melanoma cells such as p-BPA and used for BNCT. Even if this incorporation dose not happen, this will
K. Yoshino, T. Maruyama, H. Takahashi, Y. Mori, H. Kakihana, Y. Mishima, M. Ichihashi, C. Honda, M. Shiono   +8 more
openaire   +1 more source

Studies on the Uptake of Para-Boronophenylalanine in Melanoma Cells

1992
Cell-associated boron levels adequate for neutron capture therapy (NCT) have been demonstrated in-vitro using cultured melanoma cells(1) and in-vivo using xenografts in mice.(2-5) Preliminary in-vivo studies performed by researchers at the College of Veterinary Medicine, Washington State University (WSU), using a spontaneous canine melanoma model ...
M. Papageorges, C. A. Elstad, G. G. Meadows, P. R. Gavin, R. D. Sande, W. F. Bauer   +5 more
openaire   +1 more source

Capture of p-Boronophenylalanine by Melanin-Related Compounds: Complex Formation of p-Boronophenylalanine with L-Dopa

1993
There are the biologically proven facts that first, 10B-p-BPA accumulates 10B in melanoma cells, and second, the accumulation is not permanent. After reaching a saturation concentration, melanoma cells release boron1,2,3,4. The reason for the accumulation has been considered as follows. 1.
K. Yoshino, T. Maruyama, Y. Mori, H. Kakihana, Y. Mishima   +4 more
openaire   +1 more source

Toxicity associated with boronophenylalanine and cranial neutron irradiation

Radiation Oncology Investigations, 1995
AbstractBoron neutron capture therapy (BNCT) involves administration of a tumor selective boron compound followed by neutron irradiation directed at the target organ. Several studies have shown antitumor activity in animal models with BNCT using the amino acid analog boronophenylalanine (BPA). This study investigates the pharmacological toxicity of BPA
William G. Cano, Guido R. Solares, Thomas A. Dipetrillo, Sven A. G. Meylaerts, Shan C. Lin, Robert G. Zamenhof, Stephen C. Saris, Jay S. Duker, Elizabeth Goad, Hywel Madoc‐Jones, David E. Wazer   +10 more
openaire   +1 more source

Evaluation of the biological effectiveness of L-4-boronophenylalanine in glioblastomas

Applied Radiation and Isotopes
Compound biological effectiveness (CBE), arising from variances in the micro-distribution of the boron compound, is a crucial factor for converting the boron dose into the bioequivalent dose of traditional radiotherapy. This study aimed to estimate CBE values of L-4-boronophenylalanine (BPA) in glioblastomas.The survival fraction was utilized to ...
Xiaohong Zhang, Jiaomei Bai, Diyun Shu, Changran Geng, Aoyun Guo, Li Li, Aleksandr Kichigin, Qichun Wei, Xiaobin Tang, Yuanhao Liu   +9 more
openaire   +2 more sources

Biological Evaluation of Fluorinated p-Boronophenylalanine Derivatives as a Boron Carrier

Protein & Peptide Letters, 2007
Boron neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical materials utilizing both for BNCT and MRI, fluorinated p-boronophenylalanines and their alcohol derivatives had already been designed and synthesized. In the present
Yoshihide, Hattori, Kei, Kurihara, Hirofumi, Kondoh, Tomoyuki, Asano, Mitsunori, Kirihata, Yoshihiro, Yamaguchi, Tateaki, Wakamiya   +6 more
openaire   +2 more sources

Mutagenic effect of borocaptate sodium and boronophenylalanine in neutron capture therapy

International Journal of Radiation Oncology*Biology*Physics, 2002
To investigate the mutagenic effect in boron neutron capture therapy (BNCT), Chinese hamster ovary cells were incubated with 10 B-enriched borocaptate sodium (BSH) or para-boronophenylalanine (BPA) before exposure to thermal neutrons, and the occurrence of mutations at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus was measured.BSH or
Yuko, Kinashi, Shin-ichiro, Masunaga, Koji, Ono   +2 more
openaire   +2 more sources

Biodistribution studies of boronophenylalanine–fructose in melanoma and brain tumor patients in Argentina

Applied Radiation and Isotopes, 2004
A study of the (10)B-enriched p-boronophenylalanine-fructose complex ((10)BPA-F) infusion procedure in potential BNCT patients, including four melanoma of extremities and two high-grade gliomas (glioblastoma and ganglioglioma) was performed. T/B and S/B ratios for (10)B concentrations in tumor (T), blood (B) and skin (S) were determined.
S J, Liberman, A, Dagrosa, R A, Jiménez Rebagliati, M R, Bonomi, B M, Roth, L, Turjanski, S I, Castiglia, S J, González, P R, Menéndez, R, Cabrini, M J, Roberti, D A, Batistoni   +11 more
openaire   +2 more sources

Neutron Capture Therapy of a Rat Glioma Using Boronophenylalanine as a Cupture Agent

Radiation Research, 1994
The purpose of the present study was to determine the efficacy of boron neutron capture therapy (BNCT) in treating the therapeutically refractory F98 glioma, using boronophenylalanine (BPA) as the capture agent. F98 glioma cells (10(5)) were implanted stereotactically into the brains of Fischer rats and 15 days later the animals were injected ...
K Z, Matalka, R F, Barth, A E, Staubus, M L, Moeschberger, J A, Coderre   +4 more
openaire   +2 more sources