Results 131 to 140 of about 798 (156)

Effect of Dose and Infusion Time on the Delivery of p- Boronophenylalanine for Neutron Capture Therapy

Journal of Neuro-Oncology, 1999
Clinical trials of boron neutron capture therapy (BNCT) for glioblastoma multiforme are currently in progress using p-boronophenylalanine (BPA) as the 10B delivery agent. Enhancement of tumor boron uptake and/or the tumor-to-blood (T:B) boron concentration ratio would have the potential of significantly improving the therapeutic gain of BNCT.
D D, Joel, J A, Coderre, P L, Micca, M M, Nawrocky   +3 more
openaire   +2 more sources

Tolerance of the Normal Canine Brain to Epithermal Neutron Irradiation in the Presence of p-boronophenylalanine

Journal of Neuro-Oncology, 2000
Twelve normal dogs underwent brain irradiation in a mixed-radiation, mainly epithermal neutron field at the Brookhaven Medical Research Reactor following intravenous infusion of 950 mg of 10B-enriched BPA/kg as its fructose complex. The 5 x 10 cm irradiation aperture was centered over the left hemisphere.
J A, Coderre, P R, Gavin, J, Capala, R, Ma, G M, Morris, T M, Button, T, Aziz, N S, Peress   +7 more
openaire   +2 more sources

Bioavailability of Intravenous Formulations of P-Boronophenylalanine in Dog and Rat

1993
Boron neutron capture therapy (BNCT) is being developed as a treatment for malignant melanoma. P-boronophenyialanine (BPA) was initially proposed as a boron (B) delivery drug for BNCT of malignant melanoma because it was postulated that this B-containing amino acid, by mimicking a melanin precursor, would selectively accumulate in melanoma cells.
T. R. LaHann, D. R. Lu, G. Daniell, C. Sills, S. L. Kraft, P. R. Gavin, W. F. Bauer   +6 more
openaire   +1 more source

INJECTION CONTAINING p-BORONOPHENYLALANINE

2021
IGUCHI YOSHIYA, KATAKUSE YOSHIMITSU, NAKASHIMA HIDEKI   +2 more
openaire   +4 more sources

Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy

International Journal of Molecular Sciences, 2021
Hoang Tan Doan Le, Ngoc Xuan Dat Mai, Shanmugavel Chinnathambi   +2 more
exaly  

Boronophenylalanine-Fructose Complex

2020
openaire   +1 more source

Biodistribution of 10B in Glioma Orthotopic Xenograft Mouse Model after Injection of L-para-Boronophenylalanine and Sodium Borocaptate

Biomedicines, 2021
Alphiya Tsygankova, Alexander Romashchenko, Yuriy Orlov   +2 more
exaly  

BORONOPHENYLALANINE AMIDE DERIVATIVE

2023
MURATA YUSUKE, TAKENAKA HIROSHI, OTA YOICHIRO, SUDANI AYA, ISHIMURA MIKI, SUZUKI KENSUKE   +5 more
openaire   +1 more source

Glioma Stem-Like Cells Can Be Targeted in Boron Neutron Capture Therapy with Boronophenylalanine

Cancers, 2020
Eishu Hirata, Yoshinori Sakurai, Mitsutoshi Nakada   +2 more
exaly  

The pharmacokinetics of p-boronophenylalanine.fructose in human patients with glioma and metastatic melanoma

International Journal of Radiation Oncology Biology Physics, 1994
B J Allen, D E Moore, Douglas E Moore
exaly