Results 1 to 10 of about 560,945 (139)

Evaluation of sodium borocaptate (BSH) and boronophenylalanine (BPA) as boron delivery agents for neutron capture therapy (NCT) of cancer: an update and a guide for the future clinical evaluation of new boron delivery agents for NCT

Cancer Communications
Boron neutron capture therapy (BNCT) is a cancer treatment modality based on the nuclear capture and fission reactions that occur when boron‐10, a stable isotope, is irradiated with neutrons of the appropriate energy to produce boron‐11 in an unstable ...
Nilendu Gupta
exaly   +3 more sources

Biodistribution of ¹⁰B in Glioma Orthotopic Xenograft Mouse Model after Injection of L-para-Boronophenylalanine and Sodium Borocaptate [PDF]

Biomedicines, 2021
Boron neutron capture therapy (BNCT) is based on the ability of the boron-10 (10B) isotope to capture epithermal neutrons, as a result of which the isotope becomes unstable and decays into kinetically active elements that destroy cells where the nuclear ...
Natalya V. Gubanova, Alphiya R. Tsygankova, Evgenii L. Zavjalov, Alexander V. Romashchenko, Yuriy L. Orlov   +4 more
doaj   +4 more sources

Boron Neutron Capture Therapy - A Literature Review [PDF]

Journal of Clinical and Diagnostic Research, 2016
Boron Neutron Capture Therapy (BNCT) is a radiation science which is emerging as a hopeful tool in treating cancer, by selectively concentrating boron compounds in tumour cells and then subjecting the tumour cells to epithermal neutron beam radiation ...
Kavitaa Nedunchezhian, Nalini Aswath, Manigandan Thiruppathy, Sarumathi Thirugnanamurthy   +3 more
doaj   +1 more source

Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds

Biology, 2021
(1) Background: Developments in accelerator-based neutron sources moved boron neutron capture therapy (BNCT) to the next phase, where new neutron radiation parameters had to be studied for the treatment of cancers, including brain tumors.
Vladimir Kanygin, Ivan Razumov, Alexander Zaboronok, Evgenii Zavjalov, Aleksandr Kichigin, Olga Solovieva, Alphiya Tsygankova, Tatiana Guselnikova, Dmitrii Kasatov, Tatiana Sycheva, Bryan J. Mathis, Sergey Taskaev   +11 more
doaj   +1 more source

ASSESSMENT OF THE EFFECT OF BORON NEUTRON CAPTURE THERAPY ON TUMOR CELL LINES AND PRIMARY EMBRYONIC CELL CULTURE

Сибирский онкологический журнал, 2021
Introduction. Boron neutron capture therapy (bnct) is a promising method for treating tumors, in particular, infiltrative malignant tumors, due to the selective destruction of tumor cells without damaging the surrounding normal tissues.
V. V. Kanygin, A. I. Kasatova, I. A. Razumov, E. L. Zavyalov, A. I. Kichigin, R. A. Mukhamadiyarov, S. Yu. Taskaev   +6 more
doaj   +1 more source

Experimental validation of proton boron capture therapy for glioma cells

Scientific Reports, 2023
Proton boron capture therapy (PBCT) has emerged from particle acceleration research for enhancing the biological effectiveness of proton therapy. The mechanism responsible for the dose increase was supposed to be related to proton-boron fusion reactions (
Tatiana Shtam, Vladimir Burdakov, Alina Garina, Luiza Garaeva, Nhan Hau Tran, Andrey Volnitskiy, Eva Kuus, Dmitry Amerkanov, Fedor Pack, Georgy Andreev, Andrey Lubinskiy, Konstantin Shabalin, Nicolay Verlov, Evgeniy Ivanov, Victor Ezhov, Dmitry Lebedev, Andrey L. Konevega   +16 more
doaj   +1 more source

In Vivo Accelerator-Based Boron Neutron Capture Therapy for Spontaneous Tumors in Large Animals: Case Series

Biology, 2022
(1) Background: accelerator-based neutron sources are a new frontier for BNCT but many technical issues remain. We aimed to study such issues and results in larger-animal BNCT (cats and dogs) with naturally occurring, malignant tumors in different ...
Vladimir Kanygin, Aleksandr Kichigin, Alexander Zaboronok, Anna Kasatova, Elena Petrova, Alphiya Tsygankova, Evgenii Zavjalov, Bryan J. Mathis, Sergey Taskaev   +8 more
doaj   +1 more source

The basis and advances in clinical application of boron neutron capture therapy

Radiation Oncology, 2021
Boron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for cancer treatment that selectively damages cancer cells while sparing ...
Huifang He, Jiyuan Li, Ping Jiang, Suqing Tian, Hao Wang, Ruitai Fan, Junqi Liu, Yuyan Yang, Zhibo Liu, Junjie Wang   +9 more
doaj   +1 more source

Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy

BMC Cancer, 2021
Background p-Boronophenylalanine (10BPA) is a powerful 10B drug used in current clinical trials of BNCT. For BNCT to be successful, a high (500 mg/kg) dose of 10BPA must be administered over a few hours.
Tohru Yoneyama, Shingo Hatakeyama, Mihoko Sutoh-Yoneyama, Taku Yoshiya, Tsuyoshi Uemura, Takehiro Ishizu, Minoru Suzuki, Shingo Hachinohe, Shintaro Ishiyama, Motohiro Nonaka, Michiko N. Fukuda, Chikara Ohyama   +11 more
doaj   +1 more source

Tailored hyaluronic acid-based nanogels as theranostic boron delivery systems for boron neutron cancer therapy

International Journal of Pharmaceutics: X, 2022
Boron-rich nanocarriers possess great potential for advanced boron neutron capture therapy (BNCT) as an effective radiation treatment for invasive malignant tumors.
Simon Coninx, Ghadir Kalot, Amélie Godard, Ewen Bodio, Christine Goze, Lucie Sancey, Rachel Auzély-Velty   +6 more
doaj   +1 more source