Results 111 to 120 of about 798 (156)

Complex Formation of p-Boronophenylalanine With Some Monosaccharides

Pigment Cell & Melanoma Research, 1989
To increase the solubility of p‐boronophenylalanine (p‐bpa) in neutral pH solution, the complex formation of p‐bpa with some monosaccharides has been studied by 11B‐NMR and UV spectroscopy. The complex formation constants (log K) obtained by the UV method in pH 7.4 solution are 2.43 (fructose), 2.19 (mannitol), 1.28 (galactose), 1.10 (mannose), and 0 ...
Y, Mori, A, Suzuki, K, Yoshino, H, Kakihana   +3 more
exaly   +3 more sources

Liposomes containing boronophenylalanine for boron neutron capture therapy

Journal of Microencapsulation, 1998
In the present work, liposomes loaded with Boronophenylalanine (BPA), with or without stabilization, were formulated for the application in boron neutron capture therapy. BPA was encapsulated into liposomes as a complex with fructose, but also as a free drug in two different pH buffers.
F Pavanetto
exaly   +3 more sources

Selective uptake of boronophenylalanine by glioma stem/progenitor cells

Applied Radiation and Isotopes, 2012
The success of boron neutron capture therapy (BNCT) depends on the amount of boron in cells and the tumor/blood and tumor/(normal tissue) boron concentration ratios. For the first time, measurements of boron uptake in both stem/progenitor and differentiated glioma cells were performed along with measurements of boron biodistribution in suitable animal ...
Ting Sun
exaly   +3 more sources

Stability of 10B-l-boronophenylalanine–fructose injection

American Journal of Health-System Pharmacy, 2005
Boron neutron capture therapy (BNCT) is a promising technique for highly targeted tumor therapy.[1][1],[2][2] BNCT relies on the high cross-section of the nonradioactive isotope boron-10 to capture thermal neutrons, leading to the reaction 10B(n,α)7Li.
Catharina M, van Rij, Arno, Sinjewel, Arie C, van Loenen, Wolfgang A G, Sauerwein, Andrea, Wittig, Otomar, Kriz, Abraham J, Wilhelm   +6 more
openaire   +2 more sources

Improved Bioavailability of para-Boronophenylalanine by Cyclodextrin Complexation

Journal of Pharmaceutical Sciences, 1993
This study was undertaken to develop an oral dosage form for para-boronophenylalanine (BPA) plus cyclodextrin (CD) for use in the thermal neutron capture therapy for malignant melanoma. Powders of the BPA and CD complexes were obtained in a molar ratio of 1:2.
H, Hatanaka, F, Komada, Y, Mishima, K, Okumura   +3 more
openaire   +2 more sources

The Permeability of Boronophenylalanine

1996
The integrity of the blood-brain barrier may severely restrict the passage of drugs intended for cells within the central nervous system. These experiments were designed to show whether one particular drug used for the treatment of gliomas, boronophenylalanine (BPA), is affected by the state of the BBB.
H. Patel, J. W. Hopewell
openaire   +1 more source

Biodistribution studies of boronophenylalanine in different types of skin melanoma

Applied Radiation and Isotopes, 2020
A study of the 10B-enriched Boronophenylalanine-fructose complex(10BPA-F) infusion procedure in potential BNCT patients, including three skin melanomas of extremities, was performed. 10B concentration in tumor(T), blood(B), skin(S) were measured to determine tumor/blood(T/B) and skin/blood(S/B) ratios.
Zizhu, Zhang, Zhong, Yong, Congjun, Jin, Zewen, Song, Shaihong, Zhu, Tong, Liu, Yang, Chen, Yizheng, Chong, Xinru, Chen, Yongmao, Zhou   +9 more
openaire   +2 more sources