Results 91 to 100 of about 1,275 (182)

Radiosynthesis and Chiral Separation of C-11 Labeled Boronophenylalanine for Bnct Studies With Pet. [PDF]

, 2001
The overall goal of this research is to combine two powerful methodologies, boron neutron capture therapy (BNCT) and positron emission tomography (PET), to advance the treatment of patients with malignant brain tumors.
Miura, M., Studenov, A., Ferrierri, R., Coderre, J., Fowler, J.S., Ding, Y. S.   +5 more
core  

Translational research of boron neutron capture therapy for spinal cord gliomas using rat model

Scientific Reports
Boron neutron capture therapy (BNCT) is a type of targeted particle radiation therapy with potential applications at the cellular level. Spinal cord gliomas (SCGs) present a substantial challenge owing to their poor prognosis and the lack of effective ...
Ryo Kayama, Kohei Tsujino, Shinji Kawabata, Yoshiki Fujikawa, Hideki Kashiwagi, Yusuke Fukuo, Ryo Hiramatsu, Takashi Takata, Hiroki Tanaka, Minoru Suzuki, Naonori Hu, Shin-Ichi Miyatake, Toshihiro Takami, Masahiko Wanibuchi   +13 more
doaj   +1 more source

A Phase 1 Biodistribution Study of p-Boronophenylalanine [PDF]

, 1992
The United States Food and Drug Administration (FDA) has approved an Investigational New Drug (IND) Exemption for the boron-containing amino acid p-boronophenylalanine (EPA). The IND application was based upon preclinical studies carried out at Brookhaven National Laboratory that included: 1) the demonstration of selective accumulation of boron in a ...
openaire   +1 more source

Boron neutron capture therapy of brain tumors:Clinical trials at the Finnish facility using boronophenylalanine

, 2003
Two clinical trials are currently running at the Finnish dedicated boron neutron capture therapy (BNCT) facility. Between May 1999 and December 2001, 18 patients with supratentorial glioblastoma were treated with boronophenylalanine (BPA)-based BNCT ...
Savolainen, Sauli, Minn, Heikki, Auterinen, Iiro, Kankaanranta, Leena, Kulvik, Martti, Serén, Tom, Vähätalo, Jyrki, Kotiluoto, Petri; id_orcid, Karila, Johanna, Färkkilä, Markus, Kallio, Merja, Järviluoma, Eija, Brander, Antii, Ryynänen, Päivi, Ruokonen, Inkeri, Laakso, Juha, Tenhunen, Mikko, Seppälä, Tiina, Joensuu, Heikki, Kortesniemi, Mika, Jääskeläinen, Juha, Paetau, Anders   +21 more
core   +1 more source

Boron neutron capture therapy (BNCT) for glioblastoma multiforme: A phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA)

, 2008
Background and purpose: To evaluate the efficacy and safety of boron neutron capture therapy (BNCT) for glioblastoma multiforme (GBM) using a novel protocol for the boronophenylalanine-fructose (BPA-F) infusion.
Capala, Jacek, Henriksson, Roger,, Salford, Leif, Bergenheim, A. Tommy, Bergenheim, A Tommy,, Michanek, Annika, Henriksson, Roger, Lindahl, Sten-Ake, Salford, Leif G, Westlin, Jan-Erik, Blomquist, Erik,, Salford, Leif G., Franzen, Lars, Franzén, Lars,, Blomquist, Erik   +14 more
core   +1 more source

Biodistribution of (10)B for Boron Neutron Capture Therapy (BNCT) in a Mouse Model after Injection of Sodium Mercaptoundecahydro-Closo-dodecaborate and l-para-Boronophenylalanine

, 2009
In boron neutron capture therapy, the absorbed dose from the 10B(n,a)7Li reaction depends on the 10B concentration and 10B distribution in the irradiated volume. Thus compounds used in BNCT should have tumor-specific uptake and low accumulation in normal
KRIEGESKOTTE Christian, SAUERWEIN Wolfgang, HUISKAMP R., SCHERAG Andre, HILKEN Gero, MOSS Raymond, WITTIG Andrea, BET Pierre   +7 more
core   +1 more source

PRELIMINARY MATHEMATICAL MODEL FOR CANCER TREATMENT USING BORON NEUTRON CANCER THERAPY (BNCT)

Barekeng
This article outlines a revolutionary approach to immunotherapy and stem-cell cancer treatments that leverages Boron Neutron Cancer Therapy (BNCT). We formulated two models, one being the immunotherapy-BNCT model and the other featuring a stem-cell ...
Suryasatriya Trihandaru, Hanna Arini Parhusip, Yohannes Sardjono, Isman Mulyadi Triatmoko, Gede Sutresna Wijaya, Jane Labadin   +5 more
doaj   +1 more source

Comprehensive study of photon and proton interactions to interpret the radiation parameters of boron derivative drugs for chemoradiotherapy

Journal of Nigerian Society of Physical Sciences
 For chemoradiotherapy applications, this work investigated the photon and proton interaction parameters in five boron-based medications: sodium borocaptate, bortezomib, delanzomib, boronophenylalanine, and boric acid. Photon interaction parameters such
A. M. Olaosun, C. A. Aborisade, D. E. Shian, P. T. Osuolale   +3 more
doaj   +1 more source

Poly(vinyl alcohol) enhancing therapeutic effects of 4-L-boronophenylalanine on thoracic tumors in neutron capture therapy

「液体のり」の成分を利用した悪性胸膜中皮腫治療 --ホウ素中性子捕捉療法用ポリビニルアルコール製剤の実用化に向けた画期的一歩-- . 京都大学プレスリリース. 2025-07-31.Boron neutron capture therapy (BNCT) has been expected to be a promising approach to treat lung cancers in a non-invasive manner.
Tokura, Daiki, Sudani, Aya, Ishino, Yuko, Hayashi, Toshimitsu, Nomoto, Takahiro, Uehara, Koki, Nishiyama, Nobuhiro, Suzuki, Minoru, Nakashima, Hideki, Sunahara, Megumi, Konarita, Kakeru   +10 more
core   +1 more source

Aromatic boronic acids. Synthesis of o-boronophenylalanine [PDF]

The Journal of Organic Chemistry, 1968
James R. Kuszewski, William J. Lennarz, Harold R. Snyder   +2 more
openaire   +3 more sources