Results 81 to 90 of about 1,275 (182)

Taming the Immiscibility of Gold, Iron, and Boron to Craft Chemodegradable Nanoparticles for Multimodal Imaging and Radiotherapy

Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.
Over half of cancer patients undergo radiotherapy. Laser ablation enabled the synthesis of immiscible Au‐Fe‐B nanoparticles designed as degradable bimodal radiosensitizers for X‐ray radiotherapy (XRT), boron neutron capture therapy (BNCT), and bimodal imaging for X‐ray computed tomography (CT) and magnetic resonance imaging (MRI). These nanosensitizers
Michael Bissoli, Clara M.G. de Faria, Veronica Torresan, Maria Assunta Lacavalla, Mattia Cattelan, Denis Badocco, Paolo Pastore, Pasquina Marzola, Laura Cansolino, Cinzia Ferrari, Ian Postuma, Riccardo Vago, Silva Bortolussi, Antonello E. Spinelli, Daniel Forrer, Vincenzo Amendola   +15 more
wiley   +1 more source

Design and Synthesis of Boron‐Containing Noncanonical Amino Acids With Enhanced Stability and Solubility

European Journal of Organic Chemistry, Volume 29, Issue 3, January 22, 2026.
We report a new class of boron‐containing noncanonical amino acids with improved aqueous solubility and stability. Structural tuning around the boron center enhances biological compatibility, and unique fluorescence properties suggest applications in protein engineering and biosensing, advancing boron‐based tools for chemical biology and drug discovery.
Eunsol Jo, Hyojung Ahn, Guldana Issabayeva, On‐Yu Kang, Jungtaek Kim, Young‐Chul Song, Ik Jae Lee, Hei‐Cheul Jeung, Ji Young Hyun, Seong Jun Park, Hwan Jung Lim   +10 more
wiley   +1 more source

Selective uptake of p-boronophenylalanine by osteosarcoma cells for boron neutron capture therapy

, 2009
Osteosarcoma is the most common non-hematologic primary cancer type that develops in bone. Current osteosarcoma treatments combine multiagent chemotherapy with extensive surgical resection, which in some cases makes necessary the amputation of the entire
ZONTA, CECILIA, ALTIERI, SAVERIO, BORTOLUSSI, SILVA, Bruschi Piero, CANSOLINO, LAURA, DIONIGI, PAOLO, CLERICI, ANNA MARIA, GASPARI, ANNALISA, ZONTA, ARIS, FERRARI, CINZIA, STELLA, SABRINA   +10 more
core   +2 more sources

In Vitro Studies on Stability of L-p-boronophenylalanine–fructose Complex (BPA-F) [PDF]

Journal of Radiation Research, 2011
Boron neutron capture therapy (BNCT) is an experimental drug-targeted treatment combining tumour-seeking boronated drug(s) and subsequent ¹⁰B activation by neutrons. Synthetic amino acid, L-p-boronophenylalanine (BPA), administered as a fructose complex (BPA-F) is used in BNCT trials.
Heikkinen Sami, Savolainen Sauli, Heikkinen Sami, Savolainen Sauli   +3 more
openaire   +2 more sources

Evaluation of a CdTe semiconductor‐based gamma camera for real‐time dose dosimetry in boron neutron capture therapy

Medical Physics, Volume 52, Issue 10, October 2025.
Abstract Background Boron neutron capture therapy (BNCT) is a cancer treatment that leverages the nuclear reaction between boron‐10 (10B$^{10}{\rm B}$) and thermal neutrons to generate high‐energy α$\alpha$ particles and 7Li$^{7}{\rm Li}$ nuclei that selectively destroy cancer cells while sparing healthy tissues.
I‐Huan Chiu, Takahito Osawa, Takehiro Sumita, Kazuhiko Ninomiya, Shin'ichiro Takeda, Tadayuki Takahashi   +5 more
wiley   +1 more source

Structural Basis for the Specific Cotranslational Incorporation of p‑Boronophenylalanine into Biosynthetic Proteins

, 2018
The site-specific incorporation of the non-natural amino acid p-boronophenylalanine (Bpa) into recombinant proteins enables the development of novel carbohydrate-binding functions as well as bioorthogonal chemical modification.
Lea Nästle (5135807), Marietta Landgraf (5135804), Andreas J. Reichert (4520851), André Schiefner (1869397), Arne Skerra (168950)   +4 more
core   +1 more source

Boric Acid Suppresses Cell Survival by Triggering Endoplasmic Reticulum Stress‐Induced Autophagy in Cervical Cancers

Journal of Cellular and Molecular Medicine, Volume 29, Issue 14, July 2025.
ABSTRACT Cervical cancer ranks as the fourth most common cancer amongst women globally. This study aimed to investigate boric acid's effects on endoplasmic reticulum (ER) stress and autophagy signalling pathways in cervical cancer cells. We first assessed boric acid's effects on cell viability and proliferation in HUF and HeLa cell lines. Subsequently,
Betul Keyif, Ceyhan Hacioglu
wiley   +1 more source

In vivo (19)F MRI and (19)F MRS of (19)F-labelled boronophenylalanine-fructose complex on a C6 rat glioma model to optimize boron neutron capture therapy (BNCT). [PDF]

, 2008
Boron neutron capture therapy (BNCT) is a promising binary modality used to treat malignant brain gliomas. To optimize BNCT effectiveness a non-invasive method is needed to monitor the spatial distribution of BNCT carriers in order to estimate the ...
Pastore, Fs, CAPUANI S, Capuani, S, Migneco, L, La Bella, A, MARAVIGLIA, Bruno, LA BELLA, ANGELA, Lecce, M, PORCARI, PAOLA, CAMPANELLA R, FASANO F, Fasano, F, MIGNECO, Luisa Maria, PASTORE, FRANCESCO SAVERIO, Pastore, F, D'amore, E, PASTORE F. S, Campanella, R, DAMORE E, LECCE M, Porcari, P   +20 more
core   +1 more source

Evaluation of a Novel Boron-Containing α-d-Mannopyranoside for BNCT

Cells, 2020
Boron neutron capture therapy (BNCT) is a unique anticancer technology that has demonstrated its efficacy in numerous phase I/II clinical trials with boronophenylalanine (BPA) and sodium borocaptate (BSH) used as 10B delivery agents.
Takao Tsurubuchi, Makoto Shirakawa, Wataru Kurosawa, Kayo Matsumoto, Risa Ubagai, Hiroshi Umishio, Yasuyo Suga, Junko Yamazaki, Akihiro Arakawa, Yutaka Maruyama, Takuya Seki, Yusuke Shibui, Fumiyo Yoshida, Alexander Zaboronok, Minoru Suzuki, Yoshinori Sakurai, Hiroki Tanaka, Kei Nakai, Eiichi Ishikawa, Akira Matsumura   +19 more
doaj   +1 more source

Towards an adequate description of the dose‐response relationship in BNCT of glioblastoma multiforme

Medical Physics, Volume 52, Issue 4, Page 2606-2617, April 2025.
Abstract Background Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy based on the intravenous administration of a borated drug to the patient and the subsequent irradiation with a low‐energy neutron beam. The borated formulation accumulates in the tumor cells, and when neutrons interact with boron, a nuclear capture reaction occurs ...
Barbara Marcaccio, Marco Crepaldi, Ian Postuma, Erica Simeone, Claretta Guidi, Setareh Fatemi, Ricardo Luis Ramos, Valerio Vercesi, Cinzia Ferrari, Laura Cansolino, Elena Delgrosso, Riccardo Di Liberto, Daniele Dondi, Dhanalakshmi Vadivel, Yi‐Wei Chen, Fong‐In Chou, Jinn‐Jer Peir, Chuan‐Jen Wu, Hui‐Yu Tsai, Jia‐Cheng Lee, Agustina Mariana Portu, Ana Mailén Dattoli Viegas, Sara Josefina González, Silva Bortolussi   +23 more
wiley   +1 more source