Results 71 to 80 of about 798 (156)

A Phase 1 Biodistribution Study of p-Boronophenylalanine [PDF]

, 1992
The United States Food and Drug Administration (FDA) has approved an Investigational New Drug (IND) Exemption for the boron-containing amino acid p-boronophenylalanine (EPA). The IND application was based upon preclinical studies carried out at Brookhaven National Laboratory that included: 1) the demonstration of selective accumulation of boron in a ...
openaire   +1 more source

Boronophenylalanine uptake in C6 glioma model is dramatically increased by l-DOPA preloading

Applied Radiation and Isotopes, 2009
One of the main limitations for BNCT effectiveness is the insufficient intake of (10)B nuclei within tumour cells. This work was aimed at investigating the use of L-DOPA as enhancer for boronophenylalanine (BPA) uptake in the C6 glioma model. The investigation was first performed in vitro, and then extended in vivo to the animal model. BPA accumulation
CAPUANI S, GILI T, BOZZALI M, RUSSO S, PORCARI P, CAMETTI C, MUOLO M, D'AMORE E, MARAVIGLIA B, LAZZARINO, Giuseppe, PASTORE FS   +10 more
openaire   +5 more sources

Boron neutron capture therapy of cancer: where do we stand now?

Cancer Communications, Volume 44, Issue 8, Page 889-892, August 2024.
Rolf F. Barth, Gong Wu, Maria da Graca H. Vicente, John C Grecula, Nilendu Gupta   +4 more
wiley   +1 more source

Aromatic boronic acids. Synthesis of o-boronophenylalanine [PDF]

The Journal of Organic Chemistry, 1968
James R. Kuszewski, William J. Lennarz, Harold R. Snyder   +2 more
openaire   +3 more sources

PRELIMINARY MATHEMATICAL MODEL FOR CANCER TREATMENT USING BORON NEUTRON CANCER THERAPY (BNCT)

Barekeng
This article outlines a revolutionary approach to immunotherapy and stem-cell cancer treatments that leverages Boron Neutron Cancer Therapy (BNCT). We formulated two models, one being the immunotherapy-BNCT model and the other featuring a stem-cell ...
Suryasatriya Trihandaru, Hanna Arini Parhusip, Yohannes Sardjono, Isman Mulyadi Triatmoko, Gede Sutresna Wijaya, Jane Labadin   +5 more
doaj   +1 more source

Comprehensive study of photon and proton interactions to interpret the radiation parameters of boron derivative drugs for chemoradiotherapy

Journal of Nigerian Society of Physical Sciences
 For chemoradiotherapy applications, this work investigated the photon and proton interaction parameters in five boron-based medications: sodium borocaptate, bortezomib, delanzomib, boronophenylalanine, and boric acid. Photon interaction parameters such
A. M. Olaosun, C. A. Aborisade, D. E. Shian, P. T. Osuolale   +3 more
doaj   +1 more source

Abstracts

Cancer Science, Volume 116, Issue S1, Page 1-1975, January 2025.
wiley   +1 more source

L-4-Boronophenylalanine (All around the one molecule)

ARKIVOC, 2008
Igor B. Sivaev, Vladimir I. Bregadze
doaj   +1 more source

Distribution of 18F-Boronophenylalanine in B16 Melanomas

Distribution of 18F-Boronophenylalanine in B16 Melanomas
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openaire  

Boron neutron capture therapy: A new era in radiotherapy. [PDF]

Chin Med J (Engl)
Zhou L, Peng M, Chen Y, Liang H, Yin X, Mo J, Huang X, Liu Z.   +7 more
europepmc   +1 more source