Results 71 to 80 of about 1,275 (182)
Medical Physics, Volume 53, Issue 9, September 2026.Abstract Background Boron Neutron Capture Therapy (BNCT) utilizes high linear energy transfer (LET) charged particles from the 10B(n,α)7Li reaction to selectively destroy tumor cells. Unlike conventional radiation therapy, BNCT facilities rely on fixed beam ports, making patient positioning critical in treatment planning.
Yoonho Na +5 more
wiley +1 more source
Mechanistic Modeling of the Relative Biological Effectiveness of Boron Neutron Capture Therapy
Cells, 2020 Accurate dosimetry and determination of the biological effectiveness of boron neutron capture therapy (BNCT) is challenging because of the mix of different types and energies of radiation at the cellular and subcellular levels.
Seth W. Streitmatter +3 more
doaj +1 more source
Modular Synthetic Approach to Carboranyl‒Biomolecules Conjugates
Molecules, 2021 The development of novel, tumor-selective and boron-rich compounds as potential agents for use in boron neutron capture therapy (BNCT) represents a very important field in cancer treatment by radiation therapy. Here, we report the design and synthesis of
Martin Kellert +6 more
doaj +1 more source
Principles of Biocompatible Nanotube Design for High‐Performance Biomaterials
WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 4, July/August 2026.Schematic overview of nanotube‐based biomaterials for biomedical applications. ABSTRACT Nanotubes are one‐dimensional tubular structures characterized by nanoscale radial dimensions and micrometer‐scale axial lengths. Their hollow inner cavity confers a high specific surface area and distinctive physicochemical properties, enabling remarkable potential
Yue Zhong +5 more
wiley +1 more source
Applied Sciences, 2021 (1) Background: For advanced head and neck squamous cell carcinoma (HNSCC), boron neutron capture therapy (BNCT) is a potential therapeutic option, but high concentrations of boron within HNSCC are necessary. Therefore, this in vitro pilot study examined
Matthias Gielisch +3 more
doaj +1 more source
Boron neutron capture therapy of ocular melanoma and intracranial glioma using p-boronophenylalanine [PDF]
, 1990 During conventional radiotherapy, the dose that can be delivered to the tumor is limited by the tolerance of the surrounding normal tissue within the treatment volume.
Joel, D.D. +5 more
core
A Phase 1 biodistribution study of p-boronophenylalanine
, 1991 The objectives of the Phase I BPA biodistribution study are as follows: Objective 1: To establish the safety of orally administered boronophenylalanine (BPA) as determined by monitoring of patient`s vital signs and by clinical analysis of blood before ...
Coderre, J. A.
core +1 more source
Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents
Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley +1 more source
Boron neutron capture therapy of glioblastoma multiforme using the p- boronophenylalanine-fructose complex and epithermal neutrons [PDF]
, 1994 The amino acid analogue p-boronophenylalanine (BPA) is under investigation as a neutron capture agent for BNCT of glioblastoma multiforme. A series of patients undergoing surgical removal of tumor received BPA orally as the free amino acid.
Wielopolski, L. +8 more
core
, 2009 The system L-amino acid transporter-1 (LAT-1) imports p-boronophenylalanine (BPA) into cells and may play a major role in the effectiveness of BPA-based boron neutron capture therapy.
Detta, Allah, Cruickshank, Garth
core +1 more source