Results 61 to 70 of about 798 (156)

Boron Neutron Capture Therapy (BNCT) Mediated by Maleimide-Functionalized Closo-Dodecaborate Albumin Conjugates (MID:BSA) for Oral Cancer: Biodistribution Studies and In Vivo BNCT in the Hamster Cheek Pouch Oral Cancer Model

Life, 2022
Background: BNCT (Boron Neutron Capture Therapy) is a tumor-selective particle radiotherapy that combines preferential boron accumulation in tumors and neutron irradiation.
Andrea Monti Hughes, Jessica A. Goldfinger, Mónica A. Palmieri, Paula Ramos, Iara S. Santa Cruz, Luciana De Leo, Marcela A. Garabalino, Silvia I. Thorp, Paula Curotto, Emiliano C. C. Pozzi, Kazuki Kawai, Shinichi Sato, María E. Itoiz, Verónica A. Trivillin, Juan S. Guidobono, Hiroyuki Nakamura, Amanda E. Schwint   +16 more
doaj   +1 more source

Optimized ¹H MRS and MRSI methods for the in vivo detection of boronophenylalanine [PDF]

Magnetic Resonance in Medicine, 2005
AbstractBoronophenylalanine (BPA) is used as Boron‐10 carrier in boron neutron capture therapy, an experimental cancer radiotherapy. Results of quantitative, noninvasive in vivo detection and imaging of BPA in laboratory animals using 1H NMR are presented for the first time.
Peter, Bendel, Raanan, Margalit, Yoram, Salomon   +2 more
openaire   +2 more sources

Evaluation of a CdTe semiconductor‐based gamma camera for real‐time dose dosimetry in boron neutron capture therapy

Medical Physics, Volume 52, Issue 10, October 2025.
Abstract Background Boron neutron capture therapy (BNCT) is a cancer treatment that leverages the nuclear reaction between boron‐10 (10B$^{10}{\rm B}$) and thermal neutrons to generate high‐energy α$\alpha$ particles and 7Li$^{7}{\rm Li}$ nuclei that selectively destroy cancer cells while sparing healthy tissues.
I‐Huan Chiu, Takahito Osawa, Takehiro Sumita, Kazuhiko Ninomiya, Shin'ichiro Takeda, Tadayuki Takahashi   +5 more
wiley   +1 more source

Boric Acid Suppresses Cell Survival by Triggering Endoplasmic Reticulum Stress‐Induced Autophagy in Cervical Cancers

Journal of Cellular and Molecular Medicine, Volume 29, Issue 14, July 2025.
ABSTRACT Cervical cancer ranks as the fourth most common cancer amongst women globally. This study aimed to investigate boric acid's effects on endoplasmic reticulum (ER) stress and autophagy signalling pathways in cervical cancer cells. We first assessed boric acid's effects on cell viability and proliferation in HUF and HeLa cell lines. Subsequently,
Betul Keyif, Ceyhan Hacioglu
wiley   +1 more source

Towards an adequate description of the dose‐response relationship in BNCT of glioblastoma multiforme

Medical Physics, Volume 52, Issue 4, Page 2606-2617, April 2025.
Abstract Background Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy based on the intravenous administration of a borated drug to the patient and the subsequent irradiation with a low‐energy neutron beam. The borated formulation accumulates in the tumor cells, and when neutrons interact with boron, a nuclear capture reaction occurs ...
Barbara Marcaccio, Marco Crepaldi, Ian Postuma, Erica Simeone, Claretta Guidi, Setareh Fatemi, Ricardo Luis Ramos, Valerio Vercesi, Cinzia Ferrari, Laura Cansolino, Elena Delgrosso, Riccardo Di Liberto, Daniele Dondi, Dhanalakshmi Vadivel, Yi‐Wei Chen, Fong‐In Chou, Jinn‐Jer Peir, Chuan‐Jen Wu, Hui‐Yu Tsai, Jia‐Cheng Lee, Agustina Mariana Portu, Ana Mailén Dattoli Viegas, Sara Josefina González, Silva Bortolussi   +23 more
wiley   +1 more source

Non‐Canonical Amino Acids for Engineering Peptides and Proteins with new Functions

Israel Journal of Chemistry, Volume 64, Issue 8-9, September 2024.
Abstract The universal genetic code, which specifies the 20 standard amino acids (AAs), forms the basis for all natural proteins. Researchers have developed efficient and robust in vivo and in vitro strategies to overcome the constraints of the genetic code to expand the repertoire of AA building blocks that can be ribosomally incorporated into ...
Kelly Zhi Qi Zhou, Richard Obexer
wiley   +1 more source

Ultrasound‐stimulated microbubbles to enhance radiotherapy: A scoping review

Journal of Medical Imaging and Radiation Oncology, Volume 68, Issue 6, Page 740-769, September 2024.
Abstract Introduction Primarily used as ultrasound contrast agents, microbubbles have recently emerged as a versatile therapeutic vector that can be ‘burst’ to deliver payloads in the presence of suitably optimised ultrasound fields. Ultrasound‐stimulated microbubbles (USMB) have recently demonstrated improvements in treatment outcomes across a variety
Giulia McCorkell, Terrence Piva, Declan Highgate, Masao Nakayama, Moshi Geso   +4 more
wiley   +1 more source

Evaluation of a Novel Boron-Containing α-d-Mannopyranoside for BNCT

Cells, 2020
Boron neutron capture therapy (BNCT) is a unique anticancer technology that has demonstrated its efficacy in numerous phase I/II clinical trials with boronophenylalanine (BPA) and sodium borocaptate (BSH) used as 10B delivery agents.
Takao Tsurubuchi, Makoto Shirakawa, Wataru Kurosawa, Kayo Matsumoto, Risa Ubagai, Hiroshi Umishio, Yasuyo Suga, Junko Yamazaki, Akihiro Arakawa, Yutaka Maruyama, Takuya Seki, Yusuke Shibui, Fumiyo Yoshida, Alexander Zaboronok, Minoru Suzuki, Yoshinori Sakurai, Hiroki Tanaka, Kei Nakai, Eiichi Ishikawa, Akira Matsumura   +19 more
doaj   +1 more source

Multilayered proteomics reveals that JAM‐A promotes breast cancer progression via regulation of amino acid transporter LAT1

Cancer Science, Volume 115, Issue 9, Page 3153-3168, September 2024.
We uncovered junctional adhesion molecule‐A (JAM‐A), one of the transmembrane‐type tight junction proteins (TJPs), promoted breast cancer progression via regulation of amino acid transporter LAT1 using multilayered proteomics. Our findings provide a new insight into a therapeutic strategy, JAM‐A‐targeted therapy ideally combined with LAT1‐targeted ...
Kazufumi Magara, Akira Takasawa, Kumi Takasawa, Tomoyuki Aoyama, Misaki Ota, Daisuke Kyuno, Yusuke Ono, Taro Murakami, Soh Yamamoto, Yuna Nakamori, Naoya Nakahashi, Goro Kutomi, Ichiro Takemasa, Tadashi Hasegawa, Makoto Osanai   +14 more
wiley   +1 more source

Translational research of boron neutron capture therapy for spinal cord gliomas using rat model

Scientific Reports
Boron neutron capture therapy (BNCT) is a type of targeted particle radiation therapy with potential applications at the cellular level. Spinal cord gliomas (SCGs) present a substantial challenge owing to their poor prognosis and the lack of effective ...
Ryo Kayama, Kohei Tsujino, Shinji Kawabata, Yoshiki Fujikawa, Hideki Kashiwagi, Yusuke Fukuo, Ryo Hiramatsu, Takashi Takata, Hiroki Tanaka, Minoru Suzuki, Naonori Hu, Shin-Ichi Miyatake, Toshihiro Takami, Masahiko Wanibuchi   +13 more
doaj   +1 more source