Results 41 to 50 of about 798 (156)

Preparation of 10B-enriched nitroimidazole derivative by click reaction as a functional drug for hypoxia-targeting boron-neutron capture therapy

Results in Chemistry
We report a novel drug that can be used for the treatment of tumor hypoxic cells by boron neutron capture therapy. We attempted to modify p‑boronophenylalanine, a agent for this therapy in practical use, with a hypoxia-accumulating functional group, 2 ...
Tatsuya Ozasa, Miu Mizutani, Tatsuya Nishihara, Minoru Suzuki, Kazuhito Tanabe   +4 more
doaj   +1 more source

The basis and advances in clinical application of boron neutron capture therapy

Radiation Oncology, 2021
Boron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for cancer treatment that selectively damages cancer cells while sparing ...
Huifang He, Jiyuan Li, Ping Jiang, Suqing Tian, Hao Wang, Ruitai Fan, Junqi Liu, Yuyan Yang, Zhibo Liu, Junjie Wang   +9 more
doaj   +1 more source

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

Life, 2022
Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world.
Il Hyeok Seo, Jeongwoo Lee, Dasom Na, Hyunhye Kyung, Jieun Yang, Sangbong Lee, Sang June Jeon, Jae Won Choi, Kyu Young Lee, Jungyu Yi, Jaehwan Han, Mooyoung Yoo, Se Hyun Kim   +12 more
doaj   +1 more source

Proteomic Characterization of SAS Cell-Derived Extracellular Vesicles in Relation to Both BPA and Neutron Irradiation Doses

Cells, 2023
Boron neutron capture therapy (BNCT) is a selective radiotherapy based on nuclear reaction that occurs when 10B atoms accumulated in cancer cells are irradiated by thermal neutrons, triggering a nuclear fission response leading to cell death. Despite its
Davide Perico, Ying Tong, Lichao Chen, Shoji Imamichi, Yu Sanada, Masamichi Ishiai, Minoru Suzuki, Mitsuko Masutani, Pierluigi Mauri   +8 more
doaj   +1 more source

CYTOPATHIC EFFECTS OF ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY ON HUMAN GLIOBLASTOMA CELLS

Сибирский онкологический журнал, 2019
Boron neutron capture therapy (BNCT) is a targeted therapy based on a selective damage to cancer cells due to the interaction between boron-10 isotope and neutron.
V. A. Byvaltsev, E. L. Zavjalov, V. V. Kanygin, A. I. Kasatova, A. I. Kichigin, I. A. Razumov, T. V. Sycheva, S. Yu. Taskaev   +7 more
doaj   +1 more source

Effect of bevacizumab treatment on p-boronophenylalanine distribution in murine tumor [PDF]

Journal of Radiation Research, 2012
Previous studies have demonstrated that angiogenesis inhibitors can enhance tumor inhibitory effects of chemo- and radiotherapy via their action on tumor vessels. Here, we studied the effect of the angiogenesis inhibitor, bevacizumab (Avastin), on boron distribution in a murine tumor model.
Liu, Yong, Suzuki, Minoru, Masunaga, Shin-ichiro, Chen, Yi-Wei, Kashino, Genro, Tanaka, Hiroki, Sakurai, Yoshinori, Kirihata, Mitsunori, ONO, Koji   +8 more
openaire   +2 more sources

Overview of Boron Neutron Capture Therapy: a Medical Aspect

ASEAN Journal on Science and Technology for Development, 2018
Cancer is an abnormal growth of a cell due to the cell’s inability to control and maintain its proliferation, differentiation and apoptosis cycle. There are several methods to treat cancer; one of which is boron neutron capture therapy (BNCT).
Alan Anderson Bangun, Bagaswoto Poedjomartono   +1 more
doaj   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang, Junyan Li, Minhua Fan, Huafu Ouyang, Qiubo Chu, Huijie Yan, Yannan Zheng, Linxuan Huang, Gui Bao, Zhenting Ma, Shaobo Huang, Lin Li, Xiao Xu, Zhigang Liu   +13 more
wiley   +1 more source

Transporter‐Associated Therapeutic Efficacy of an SMVT‐Targeted Boron Carrier in Boron Neutron Capture Therapy

Cancer Science, EarlyView.
The transporter‐associated BNCT strategy using BBCIP with or without BPA according to tumor transporter characteristics. BPA showed greater efficacy in LAT1‐dominant F98 glioma, whereas BBCIP was more effective in SMVT‐high CRL1666 tumors, suggesting the potential utility of transporter‐based boron carrier selection in BNCT.
Kenichiro Eza, Kohei Tsujino, Rina Shidoh‐Kazuki, Yoshiki Fujikawa, Hideki Kashiwagi, Gen Futamura, Ryo Hiramatsu, Toshihiro Takami, Masahiko Wanibuchi, Naonori Hu, Hiroki Tanaka, Minoru Suzuki, Kai Nishimura, Shota Tanaka, Hiroyuki Nakamura, Shinji Kawabata   +15 more
wiley   +1 more source

A coarse‐to‐fine framework combining deep learning and Monte Carlo for BNCT patient position optimization toward inverse planning

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background Boron Neutron Capture Therapy (BNCT) utilizes high linear energy transfer (LET) charged particles from the 10B(n,α)7Li reaction to selectively destroy tumor cells. Unlike conventional radiation therapy, BNCT facilities rely on fixed beam ports, making patient positioning critical in treatment planning.
Yoonho Na, Chang‐min Lee, Kyuri Kim, Hyungjoo Cho, Jimin Lee, Sung‐Joon Ye   +5 more
wiley   +1 more source