Results 51 to 60 of about 798 (156)
Principles of Biocompatible Nanotube Design for High‐Performance Biomaterials
WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 4, July/August 2026.Schematic overview of nanotube‐based biomaterials for biomedical applications. ABSTRACT Nanotubes are one‐dimensional tubular structures characterized by nanoscale radial dimensions and micrometer‐scale axial lengths. Their hollow inner cavity confers a high specific surface area and distinctive physicochemical properties, enabling remarkable potential
Yue Zhong +5 more
wiley +1 more source
Mechanistic Modeling of the Relative Biological Effectiveness of Boron Neutron Capture Therapy
Cells, 2020 Accurate dosimetry and determination of the biological effectiveness of boron neutron capture therapy (BNCT) is challenging because of the mix of different types and energies of radiation at the cellular and subcellular levels.
Seth W. Streitmatter +3 more
doaj +1 more source
Scientific Reports, 2023 Boron neutron capture therapy (BNCT) is a high-LET particle radiotherapy clinically tested for treating malignant gliomas. Boronophenylalanine (BPA), a boron-containing phenylalanine derivative, is selectively transported into tumor cells by amino acid ...
Masao Fukumura +15 more
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Clinical and Translational Radiation Oncology, 2022 Purpose: This study reports the first-in-human use of a linear accelerator-based boron neutron capture therapy (BNCT) system and the first treatment of patients with scalp-angiosarcoma with accelerator-based BNCT.
Hiroshi Igaki +20 more
doaj +1 more source
Improving the bioactivity of rHirudin with boronophenylalanine site-specific modification
Molecular Medicine Reports, 2015 To improve the bioactivity of recombinant (r)Hirudin, the orthogonal pair MjBTyrRS/tRNATyr cua (made up of the boronophenylalanine, tRNA and tRNA synthetase), was selected to incorporate boronophenylalanine site‑specifically into rHirudin at the 63 sites in an Escherichia coli system in response to the TAG codon.
Xiujuan, Xin, Wenshe, Liu, Liyun, Sun
openaire +3 more sources
Modular Synthetic Approach to Carboranyl‒Biomolecules Conjugates
Molecules, 2021 The development of novel, tumor-selective and boron-rich compounds as potential agents for use in boron neutron capture therapy (BNCT) represents a very important field in cancer treatment by radiation therapy. Here, we report the design and synthesis of
Martin Kellert +6 more
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Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents
Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
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Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.Over half of cancer patients undergo radiotherapy. Laser ablation enabled the synthesis of immiscible Au‐Fe‐B nanoparticles designed as degradable bimodal radiosensitizers for X‐ray radiotherapy (XRT), boron neutron capture therapy (BNCT), and bimodal imaging for X‐ray computed tomography (CT) and magnetic resonance imaging (MRI). These nanosensitizers
Michael Bissoli +15 more
wiley +1 more source
Applied Sciences, 2021 (1) Background: For advanced head and neck squamous cell carcinoma (HNSCC), boron neutron capture therapy (BNCT) is a potential therapeutic option, but high concentrations of boron within HNSCC are necessary. Therefore, this in vitro pilot study examined
Matthias Gielisch +3 more
doaj +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 3, January 22, 2026.We report a new class of boron‐containing noncanonical amino acids with improved aqueous solubility and stability. Structural tuning around the boron center enhances biological compatibility, and unique fluorescence properties suggest applications in protein engineering and biosensing, advancing boron‐based tools for chemical biology and drug discovery.
Eunsol Jo +10 more
wiley +1 more source