Results 51 to 60 of about 1,275 (182)
Life, 2022 The blood–brain barrier (BBB) is likely to be intact during the early stages of brain metastatic melanoma development, and thereby inhibits sufficient drug delivery into the metastatic lesions.
Sachie Kusaka +7 more
doaj +1 more source
Specific Killing Effect of 10B1-Para-boronophenylalanine in Thermal Neutron Capture Therapy of Malignant Melanoma: In Vitro Radiobiological Evaluation [PDF]
, 1982 A 10B-dopa analogue, 10B1-para-boronophenylalanine (10B1-BPA) has been found to have a marked melanoma killing effect as expressed by the Do value, 0.9−1.2 × 1012 n/cm2. The Do value of the neutron alone is 2.8 × 1012 n/cm2.After the introduction of high
Mishima, Yutaka +2 more
core +1 more source
Catalytic asymmetric synthesis of α-methyl-p-boronophenylalanine [PDF]
Bioorganic & Medicinal Chemistry Letters, 2018 p-Boronophenylalanine (l-BPA) is applied in clinical settings as a boron carrier for boron neutron capture therapy (BNCT) to cure malignant melanomas. Structural modification or derivatization of l-BPA, however, to improve its uptake efficiency into tumor cells has scarcely been investigated. We successfully synthesized (S)-2-amino-3-(4-boronophenyl)-2-
Shingo, Harada +5 more
openaire +4 more sources
, 2000 A reversed-phase high-performance liquid chromatographic method for the detection of boronophenylalanine is described. Determination was obtained by precolumn reaction of o-phthalaldehyde with a mixture of standard amino acids containing ...
Fazzina, G +12 more
core +1 more source
The basis and advances in clinical application of boron neutron capture therapy
Radiation Oncology, 2021 Boron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for cancer treatment that selectively damages cancer cells while sparing ...
Huifang He +9 more
doaj +1 more source
Life, 2022 Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world.
Il Hyeok Seo +12 more
doaj +1 more source
Cells, 2023 Boron neutron capture therapy (BNCT) is a selective radiotherapy based on nuclear reaction that occurs when 10B atoms accumulated in cancer cells are irradiated by thermal neutrons, triggering a nuclear fission response leading to cell death. Despite its
Davide Perico +8 more
doaj +1 more source
, 2022 The incorporation of a phenylboronic acid group has appeared as an attractive strategy to build smart drug delivery systems. Here, we report novel synthesis of phenylboronic acid-functionalized copolypeptides based on an l-boronophenylalanine N ...
Yuanyuan Liu (136992) +6 more
core +1 more source
Effect of bevacizumab treatment on p-boronophenylalanine distribution in murine tumor [PDF]
Journal of Radiation Research, 2012 Previous studies have demonstrated that angiogenesis inhibitors can enhance tumor inhibitory effects of chemo- and radiotherapy via their action on tumor vessels. Here, we studied the effect of the angiogenesis inhibitor, bevacizumab (Avastin), on boron distribution in a murine tumor model.
Liu, Yong +8 more
openaire +2 more sources
Overview of Boron Neutron Capture Therapy: a Medical Aspect
ASEAN Journal on Science and Technology for Development, 2018 Cancer is an abnormal growth of a cell due to the cell’s inability to control and maintain its proliferation, differentiation and apoptosis cycle. There are several methods to treat cancer; one of which is boron neutron capture therapy (BNCT).
Alan Anderson Bangun +1 more
doaj +1 more source