Results 31 to 40 of about 798 (156)

A Novel Boron Lipid to Modify Liposomal Surfaces for Boron Neutron Capture Therapy

Cells, 2021
Boron neutron capture therapy (BNCT) is a cancer treatment with clinically demonstrated efficacy using boronophenylalanine (BPA) and sodium mercaptododecaborate (BSH).
Makoto Shirakawa, Alexander Zaboronok, Kei Nakai, Yuhki Sato, Sho Kayaki, Tomonori Sakai, Takao Tsurubuchi, Fumiyo Yoshida, Takashi Nishiyama, Minoru Suzuki, Hisao Tomida, Akira Matsumura   +11 more
doaj   +1 more source

Boronophenylalanine for neutron capture therapy of melanoma.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1989
Strahlenther ...
Coderre, J. A., Glass, J. D., Fairchild, R. G., Micca, P., Kalef-Ezra, J.   +4 more
openaire   +3 more sources

Amino Acid-Based Boron Carriers in Boron Neutron Capture Therapy (BNCT)

Pharmaceutics, 2023
Interest in the design of boronated amino acids has emerged, partly due to the utilization of boronophenylalanine (BPA), one of the two agents employed in clinical Boron Neutron Capture Therapy (BNCT).
Juulia Järvinen, Herkko Pulkkinen, Jarkko Rautio, Juri M. Timonen   +3 more
doaj   +1 more source

Dose Rate Effect on Cell Survival in BNCT

Current Issues in Molecular Biology, 2023
The output constancy of the accelerator used for boron neutron capture therapy (BNCT) is essential to ensuring anti-tumor efficacy and safety. BNCT as currently practiced requires a wide variety of beam quality assessments to ensure that RBE dose errors ...
Katsumi Hirose, Mariko Sato, Koji Ichise, Masahiko Aoki   +3 more
doaj   +1 more source

Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis. [PDF]

PLoS ONE, 2014
The blood-brain barrier (BBB) can be transiently disrupted by focused ultrasound (FUS) in the presence of microbubbles for targeted drug delivery. Previous studies have illustrated the pharmacokinetics of drug delivery across the BBB after sonication ...
Feng-Yi Yang, Yi-Li Lin, Fong-In Chou, Yu-Chuan Lin, Yen-Wan Hsueh Liu, Lun-Wei Chang, Yu-Ling Hsieh   +6 more
doaj   +1 more source

Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy

Biology, 2022
Boron neutron capture therapy (BNCT) is a non-invasive therapeutic technique for treating malignant tumors, however, methods to evaluate its therapeutic efficacy and adverse reactions are lacking.
Shoji Imamichi, Lichao Chen, Tasuku Ito, Ying Tong, Takae Onodera, Yuka Sasaki, Satoshi Nakamura, PierLuigi Mauri, Yu Sanada, Hiroshi Igaki, Yasufumi Murakami, Minoru Suzuki, Jun Itami, Shinichiro Masunaga, Mitsuko Masutani   +14 more
doaj   +1 more source

Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation in BNCT of Brain-Tumor-Model Rats—Ex Vivo Imaging of BPA Using MALDI Mass Spectrometry Imaging

Life, 2022
The blood–brain barrier (BBB) is likely to be intact during the early stages of brain metastatic melanoma development, and thereby inhibits sufficient drug delivery into the metastatic lesions.
Sachie Kusaka, Yumi Miyake, Yugo Tokumaru, Yuri Morizane, Shingo Tamaki, Yoko Akiyama, Fuminobu Sato, Isao Murata   +7 more
doaj   +1 more source

o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity

Molecules, 2018
Morpholine- and bis(2-methoxyethyl)amine-substituted 1,3,5-triazine derivatives containing an alkoxy-o-carborane in the 6-position of the triazine ring were successfully synthesized.
Guo Fan Jin, Hyun Seung Ban, Hiroyuki Nakamura, Jong-Dae Lee   +3 more
doaj   +1 more source

Biodistribution of ¹⁰B in Glioma Orthotopic Xenograft Mouse Model after Injection of L-para-Boronophenylalanine and Sodium Borocaptate

Biomedicines, 2021
Boron neutron capture therapy (BNCT) is based on the ability of the boron-10 (10B) isotope to capture epithermal neutrons, as a result of which the isotope becomes unstable and decays into kinetically active elements that destroy cells where the nuclear ...
Natalya V. Gubanova, Alphiya R. Tsygankova, Evgenii L. Zavjalov, Alexander V. Romashchenko, Yuriy L. Orlov   +4 more
doaj   +1 more source

Catalytic asymmetric synthesis of α-methyl-p-boronophenylalanine [PDF]

Bioorganic & Medicinal Chemistry Letters, 2018
p-Boronophenylalanine (l-BPA) is applied in clinical settings as a boron carrier for boron neutron capture therapy (BNCT) to cure malignant melanomas. Structural modification or derivatization of l-BPA, however, to improve its uptake efficiency into tumor cells has scarcely been investigated. We successfully synthesized (S)-2-amino-3-(4-boronophenyl)-2-
Shingo, Harada, Ryota, Kajihara, Risa, Muramoto, Promsuk, Jutabha, Naohiko, Anzai, Tetsuhiro, Nemoto   +5 more
openaire   +4 more sources