Results 31 to 40 of about 1,275 (182)

Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds

Biology, 2021
(1) Background: Developments in accelerator-based neutron sources moved boron neutron capture therapy (BNCT) to the next phase, where new neutron radiation parameters had to be studied for the treatment of cancers, including brain tumors.
Vladimir Kanygin, Ivan Razumov, Alexander Zaboronok, Evgenii Zavjalov, Aleksandr Kichigin, Olga Solovieva, Alphiya Tsygankova, Tatiana Guselnikova, Dmitrii Kasatov, Tatiana Sycheva, Bryan J. Mathis, Sergey Taskaev   +11 more
doaj   +1 more source

Targeted Nanoliposomes for the Delivery of Boronophenylalanine into HER2-Positive Cells. [PDF]

Acta Naturae
Boron neutron capture therapy (BNCT) is a rapidly developing field of radiation therapy for cancer that is based on the accumulation of the radiosensitive 10B isotope in cancer cells, followed by tumor irradiation with thermal neutrons. Widespread use of BNCT in clinical practice remains limited because of the poor accumulation of boron-containing (10B)
Proshkina GM, Shramova EI, Mirkasymov AB, Zavestovskaya IN, Deyev SM.   +4 more
europepmc   +4 more sources

Boron Neutron Capture Therapy - A Literature Review [PDF]

Journal of Clinical and Diagnostic Research, 2016
Boron Neutron Capture Therapy (BNCT) is a radiation science which is emerging as a hopeful tool in treating cancer, by selectively concentrating boron compounds in tumour cells and then subjecting the tumour cells to epithermal neutron beam radiation ...
Kavitaa Nedunchezhian, Nalini Aswath, Manigandan Thiruppathy, Sarumathi Thirugnanamurthy   +3 more
doaj   +1 more source

Correlation between L‐amino acid transporter 1 expression and 4‐borono‐2‐18F‐fluoro‐phenylalanine accumulation in humans

Cancer Medicine, 2023
Background The correlation between L‐type amino acid transporter 1 (LAT1) expression and 4‐borono‐2‐18F‐fluoro‐phenylalanine (18F‐FBPA) accumulation in humans remains unclear.
Tairo Kashihara, Taisuke Mori, Tetsu Nakaichi, Satoshi Nakamura, Kimiteru Ito, Hiroaki Kurihara, Masahiko Kusumoto, Jun Itami, Seiichi Yoshimoto, Hiroshi Igaki   +9 more
doaj   +1 more source

The Incorporation of Boronophenylalanine Into Phage Display Libraries for Identifying Inhibitors of Cd44 [PDF]

, 2022
Many cancers, including breast and pancreatic, are known to display similar cancer stem cell markers, and the CD44 receptor is a common marker.
Coleman, Demonta Devone
core   +1 more source

L-Phenylalanine restriction enhances L-boronophenylalanine uptake and improves boron neutron capture therapy efficacy in tumor cell lines. [PDF]

PLoS One
Boron neutron capture therapy (BNCT) relies on the selective uptake of boron-10 compounds by tumor cells. L-boronophenylalanine (BPA) serves as a key carrier, and enhancing its accumulation is critical for improving BNCT efficacy.
Tamari Y, Saba R, Takata T, Kimura H, Takita M, Yashiro K, Suzuki M, Yamazaki H, Yamada K.   +8 more
europepmc   +2 more sources

Nanostructured boron agents for boron neutron capture therapy: a review of recent patents

Medical Review, 2023
Boron neutron capture therapy (BNCT) is a potential radiation therapy modality for cancer, and tumor-targeted stable boron-10 (10B) delivery agents are an important component of BNCT. Currently, two low-molecular-weight boron-containing compounds, sodium
Zhang Xiyin, Lin Yusheng, Hosmane Narayan S., Zhu Yinghuai   +3 more
doaj   +1 more source

Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment

Cells, 2022
Boron neutron capture therapy is a low-invasive cancer therapy based on the neutron fission process that occurs upon thermal neutron irradiation of 10B-containing compounds; this process causes the release of alpha particles that selectively damage ...
Giorgia Ailuno, Alice Balboni, Gabriele Caviglioli, Francesco Lai, Federica Barbieri, Irene Dellacasagrande, Tullio Florio, Sara Baldassari   +7 more
doaj   +1 more source

Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells

Frontiers in Oncology, 2023
Boron Neutron Capture Therapy (BNCT) is a new binary radiation therapy for tumor tissue, which kills tumor cells with neutron capture reaction. Boron neutron capture therapy has become a technical means for glioma, melanoma, and other diseases has been ...
Song Wang, Song Wang, Zhengchao Zhang, Zhengchao Zhang, Lele Miao, Lele Miao, Jiaxing Zhang, Jiaxing Zhang, Futian Tang, Futian Tang, Muzhou Teng, Muzhou Teng, Yumin Li, Yumin Li   +13 more
doaj   +1 more source

Water-Soluble closo-Docecaborate-Containing Pteroyl Derivatives Targeting Folate Receptor-Positive Tumors for Boron Neutron Capture Therapy

Cells, 2020
Water-soluble pteroyl-closo-dodecaborate conjugates (PBCs 1–4), were developed as folate receptor (FRα) targeting boron carriers for boron neutron capture therapy (BNCT).
Fumiko Nakagawa, Hidehisa Kawashima, Taiki Morita, Hiroyuki Nakamura   +3 more
doaj   +1 more source