Results 11 to 20 of about 798 (156)

Targeted Nanoliposomes for the Delivery of Boronophenylalanine into HER2-Positive Cells. [PDF]

Acta Naturae
Boron neutron capture therapy (BNCT) is a rapidly developing field of radiation therapy for cancer that is based on the accumulation of the radiosensitive 10B isotope in cancer cells, followed by tumor irradiation with thermal neutrons. Widespread use of BNCT in clinical practice remains limited because of the poor accumulation of boron-containing (10B)
Proshkina GM, Shramova EI, Mirkasymov AB, Zavestovskaya IN, Deyev SM.   +4 more
europepmc   +4 more sources

The Therapeutic Effects of Dodecaborate Containing Boronophenylalanine for Boron Neutron Capture Therapy in a Rat Brain Tumor Model

Biology, 2020
Background: The development of effective boron compounds is a major area of research in the study of boron neutron capture therapy (BNCT). We created a novel boron compound, boronophenylalanine–amide alkyl dodecaborate (BADB), for application in BNCT and
Shinji Kawabata, Takuya Kanemitsu, Shin-Ichi Miyatake   +2 more
exaly   +3 more sources

Systemic Immunity Triggered by Boron Neutron Capture Therapy via Manganese-Borate Complex [PDF]

Materials Today Bio
Conventional radiotherapy compromises antitumor immunity through collateral damage to immune cells. While boron neutron capture therapy (BNCT) enables tumor-selective 10B (n, α) 7Li reactions, clinical agents like boronophenylalanine (BPA) suffer from ...
Chang Chen, Chao Wang, Lin Zhang, Yue Yu, Xu Li, Wenhao Pan, Yuanyu Liu, Jiheng Wang, Maosong Yang, Bing Hong, Xingguang Hu, Jichao Wang, Yuzhong Qian, Xiancai Meng, Yinghuai Zhu, Zhigang Liu, Shaobo Huang, Lizheng Liang, Jinhui Wu, Yang Liu   +19 more
doaj   +2 more sources

Neutron capture-enhanced proton beam therapy outside the irradiation field: in vitro experiments [PDF]

BMC Research Notes
Objective To evaluate the cell-killing effects of neutron capture-enhanced particle therapy (NCEPT) outside the proton beam irradiation (PBI) field. Results Human osteosarcoma cells (MG63) were divided into control and NCEPT groups.
Shintaro Shiba, Takahiro Shimo, Masashi Yamanaka, Kazuki Matsumoto, Akihiro Yamano, Kazunori Nitta, Makoto Sakai, Tatsuya Ohno, Koichi Tokuuye, Motoko Omura   +9 more
doaj   +2 more sources

Biological evaluation of a glucose-based boron carrier as a potential agent for boron neutron capture therapy. [PDF]

Int J Cancer
What's New? Boron neutron capture therapy (BNCT) is a targeted form of radiation therapy designed to selectively destroy cancer cells. BNCT is not widely used, however, owing in part to challenges involving selective boron delivery to tumors. The present study evaluated the potential of a novel glucoconjugate, 6‐O‐(o‐carboranylmethyl)‐d‐glucopyranose ...
Imlimthan S, Bahrami K, Pehkonen H, Centanni A, Montaser AB, Värä A, Matović J, Liljenbäck H, Auchynnikava T, Huttunen KM, Roivainen A, Airaksinen AJ, Ekholm FS, Monni O, Rautio J, Sarparanta M.   +15 more
europepmc   +2 more sources

Process Optimization of Novel Boronophenylalanine Liposomes Through Box–Behnken Response Surface Design and Preliminary Evaluation in A549 Lung Carcinoma Cells for Boron Neutron Capture Therapy [PDF]

Molecules
Boron neutron capture therapy (BNCT) is a binary targeted radiotherapy that uses boron agents to treat refractory malignancies. This study developed a novel boronophenylalanine (BPA)-loaded liposome doped with o-carborane (CB) for BNCT.
Haojie Shi, Qianlong Xu, Fenglin Li, Caiyun Fan, Yi Han   +4 more
doaj   +2 more sources

Uptakes of boronophenylalanine in the in vitro and in situ glioblastoma and the potential efficacy of boron neutron capture therapy [PDF]

IBRO Neuroscience Reports
Human glioblastoma (GBM) is the most malignant brain tumor. Boron neutron capture therapy (BNCT) is proved to be a new technology for the effective treatment of GBM.
Shining Zhang, Yujie Wei, Wenjiao Gu, Shuangyi Li, Ting Liu, Limei Shuai, Yu Tang, Ying Jiang, Xiaochun Zhou, Yucai Wei, Guan Wang, Long Gu, Yumin Li, Futian Tang, Daiying Zuo   +14 more
doaj   +2 more sources

Polyethylene glycol complexed with boronophenylalanine as a potential alternative to fructose-boronophenylalanine complexation to increase cellular uptake for BNCT treatment

Drug Development and Industrial Pharmacy
Boron Neutron Capture Therapy (BNCT) is a novel precision radiotherapy. The key to BNCT application lies in the effective targeting and retention of the boron-10 (10B) carrier. Among the various compounds studied in clinical settings, 4-boronophenylalanine (BPA) become the most prevalent one currently.
Xiaoyan Bao, Yaxin Qin
exaly   +3 more sources

Evaluation of the Key Advantages between Two Modalities of Boronophenylalanine Administration for Clinical Boron Neutron Capture Therapy Using an Animal Model

Cells, 2022
In clinical boron neutron capture therapy (BNCT), boronophenylalanine (BPA) administrations through one-step infusion (OSI) and two-step infusion (TSI) are the most widely used.
YÜ-CHÜAN Lin, Yi-Jang Lee, Yi-Wei Chen   +2 more
exaly   +3 more sources

Therapeutic Effect of Boron Neutron Capture Therapy on Boronophenylalanine Administration via Cerebrospinal Fluid Circulation in Glioma Rat Models [PDF]

Cells
In recent years, various drug delivery systems circumventing the blood–brain barrier have emerged for treating brain tumors. This study aimed to improve the efficacy of brain tumor treatment in boron neutron capture therapy (BNCT) using cerebrospinal ...
Sachie Kusaka, Nikolaos Voulgaris, Kazuki Onishi, Junpei Ueda, Shigeyoshi Saito, Shingo Tamaki, Isao Murata, Takushi Takata, Minoru Suzuki   +8 more
doaj   +2 more sources