Results 11 to 20 of about 1,275 (182)

Therapeutic Effect of Boron Neutron Capture Therapy on Boronophenylalanine Administration via Cerebrospinal Fluid Circulation in Glioma Rat Models [PDF]

Cells
In recent years, various drug delivery systems circumventing the blood–brain barrier have emerged for treating brain tumors. This study aimed to improve the efficacy of brain tumor treatment in boron neutron capture therapy (BNCT) using cerebrospinal ...
Sachie Kusaka, Nikolaos Voulgaris, Kazuki Onishi, Junpei Ueda, Shigeyoshi Saito, Shingo Tamaki, Isao Murata, Takushi Takata, Minoru Suzuki   +8 more
doaj   +6 more sources

Lipoic acid-boronophenylalanine-derived multifunctional vesicles for cancer chemoradiotherapy [PDF]

Nature Communications
Cancer remains a major health challenge, with the effectiveness of chemotherapy often limited by its lack of specificity and systemic toxicity. Nanotechnology, particularly in targeted drug delivery, has emerged as a key innovation to address these ...
Liqun Dai, Jie Liu, Tingyu Yang, Xiaorui Yu, Yi Lu, Lili Pan, Siming Zhou, Diyun Shu, Yuanhao Liu, Wuyu Mao, Zhiyong Qian   +10 more
doaj   +4 more sources

Evaluation of Pharmacokinetics of Boronophenylalanine and Its Uptakes in Gastric Cancer

Frontiers in Oncology, 2022
Boron neutron capture therapy (BNCT), a cellular-level particle radiation therapy, combines boron compounds selectively delivered to tumor tissue with neutron irradiation.
Futian Tang, Futian Tang, Yujie Wei, Shining Zhang, Jianrong Wang, Wenjiao Gu, Fenxia Tang, Xiaohuan Peng, Yucai Wei, Jiangyan Liu, Weiqiang Chen, Weiqiang Chen, Weiqiang Chen, Shixu Zhang, Long Gu, Yumin Li, Yumin Li   +16 more
doaj   +3 more sources

Clinical application of boron neutron capture therapy for cancer treatment: A systematic review. [PDF]

Precis Radiat Oncol
This review provides an overview of the development of boron‐containing drugs, and the progress made in clinical studies of BNCT, in order to promote the research and development of accelerator‐based neutron sources, increase the tumor‐targeting of boron drugs, and improve BNCT efficacy to treat malignancies.
Zhou L, Chen Y, Peng M, Yin X, Liang H, Mo J, Zhang W, Liu Z.   +7 more
europepmc   +2 more sources

Preparation of 10B-enriched nitroimidazole derivative by click reaction as a functional drug for hypoxia-targeting boron-neutron capture therapy

Results in Chemistry
We report a novel drug that can be used for the treatment of tumor hypoxic cells by boron neutron capture therapy. We attempted to modify p‑boronophenylalanine, a agent for this therapy in practical use, with a hypoxia-accumulating functional group, 2 ...
Tatsuya Ozasa, Miu Mizutani, Tatsuya Nishihara, Minoru Suzuki, Kazuhito Tanabe   +4 more
doaj   +2 more sources

Biodistribution of ¹⁰B in Glioma Orthotopic Xenograft Mouse Model after Injection of L-para-Boronophenylalanine and Sodium Borocaptate

Biomedicines, 2021
Boron neutron capture therapy (BNCT) is based on the ability of the boron-10 (10B) isotope to capture epithermal neutrons, as a result of which the isotope becomes unstable and decays into kinetically active elements that destroy cells where the nuclear ...
Natalya V. Gubanova, Alphiya R. Tsygankova, Evgenii L. Zavjalov, Alexander V. Romashchenko, Yuriy L. Orlov   +4 more
doaj   +3 more sources

Systemic Immunity Triggered by Boron Neutron Capture Therapy via Manganese-Borate Complex [PDF]

Materials Today Bio
Conventional radiotherapy compromises antitumor immunity through collateral damage to immune cells. While boron neutron capture therapy (BNCT) enables tumor-selective 10B (n, α) 7Li reactions, clinical agents like boronophenylalanine (BPA) suffer from ...
Chang Chen, Chao Wang, Lin Zhang, Yue Yu, Xu Li, Wenhao Pan, Yuanyu Liu, Jiheng Wang, Maosong Yang, Bing Hong, Xingguang Hu, Jichao Wang, Yuzhong Qian, Xiancai Meng, Yinghuai Zhu, Zhigang Liu, Shaobo Huang, Lizheng Liang, Jinhui Wu, Yang Liu   +19 more
doaj   +2 more sources

Process Optimization of Novel Boronophenylalanine Liposomes Through Box–Behnken Response Surface Design and Preliminary Evaluation in A549 Lung Carcinoma Cells for Boron Neutron Capture Therapy [PDF]

Molecules
Boron neutron capture therapy (BNCT) is a binary targeted radiotherapy that uses boron agents to treat refractory malignancies. This study developed a novel boronophenylalanine (BPA)-loaded liposome doped with o-carborane (CB) for BNCT.
Haojie Shi, Qianlong Xu, Fenglin Li, Caiyun Fan, Yi Han   +4 more
doaj   +2 more sources

Neutron capture-enhanced proton beam therapy outside the irradiation field: in vitro experiments [PDF]

BMC Research Notes
Objective To evaluate the cell-killing effects of neutron capture-enhanced particle therapy (NCEPT) outside the proton beam irradiation (PBI) field. Results Human osteosarcoma cells (MG63) were divided into control and NCEPT groups.
Shintaro Shiba, Takahiro Shimo, Masashi Yamanaka, Kazuki Matsumoto, Akihiro Yamano, Kazunori Nitta, Makoto Sakai, Tatsuya Ohno, Koichi Tokuuye, Motoko Omura   +9 more
doaj   +2 more sources

Biological evaluation of a glucose-based boron carrier as a potential agent for boron neutron capture therapy. [PDF]

Int J Cancer
What's New? Boron neutron capture therapy (BNCT) is a targeted form of radiation therapy designed to selectively destroy cancer cells. BNCT is not widely used, however, owing in part to challenges involving selective boron delivery to tumors. The present study evaluated the potential of a novel glucoconjugate, 6‐O‐(o‐carboranylmethyl)‐d‐glucopyranose ...
Imlimthan S, Bahrami K, Pehkonen H, Centanni A, Montaser AB, Värä A, Matović J, Liljenbäck H, Auchynnikava T, Huttunen KM, Roivainen A, Airaksinen AJ, Ekholm FS, Monni O, Rautio J, Sarparanta M.   +15 more
europepmc   +2 more sources