Results 21 to 30 of about 1,275 (182)

5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy

Scientific Reports, 2023
Boron neutron capture therapy (BNCT) is a high-LET particle radiotherapy clinically tested for treating malignant gliomas. Boronophenylalanine (BPA), a boron-containing phenylalanine derivative, is selectively transported into tumor cells by amino acid ...
Masao Fukumura, Naosuke Nonoguchi, Shinji Kawabata, Ryo Hiramatsu, Gen Futamura, Koji Takeuchi, Takuya Kanemitsu, Takushi Takata, Hiroki Tanaka, Minoru Suzuki, Oltea Sampetrean, Naokado Ikeda, Toshihiko Kuroiwa, Hideyuki Saya, Ichiro Nakano, Masahiko Wanibuchi   +15 more
doaj   +2 more sources

Boronophenylalanine uptake in C6 glioma model is dramatically increased by L-DOPA preloading

Applied Radiation and Isotopes, 2009
One of the main limitations for BNCT effectiveness is the insufficient intake of (10)B nuclei within turnout cells. This work was aimed at investigating the use Of L-DOPA as enhancer for boronophenylalanine (BPA) uptake in the C6 glioma model.
S. Russo, M. Muolo, Gili, T, CAMETTI, Cesare, F. S. Pastore, MARAVIGLIA, Bruno, T. Gili, E. Damore, G. Lazzarino, CAPUANI, Silvia, PORCARI, PAOLA, M. Bozzali   +11 more
core   +6 more sources

The Permeability of Boronophenylalanine

, 1996
The integrity of the blood-brain barrier may severely restrict the passage of drugs intended for cells within the central nervous system. These experiments were designed to show whether one particular drug used for the treatment of gliomas, boronophenylalanine (BPA), is affected by the state of the BBB.
H. Patel, J. W. Hopewell
core   +2 more sources

Uptakes of boronophenylalanine in the in vitro and in situ glioblastoma and the potential efficacy of boron neutron capture therapy [PDF]

IBRO Neuroscience Reports
Human glioblastoma (GBM) is the most malignant brain tumor. Boron neutron capture therapy (BNCT) is proved to be a new technology for the effective treatment of GBM.
Shining Zhang, Yujie Wei, Wenjiao Gu, Shuangyi Li, Ting Liu, Limei Shuai, Yu Tang, Ying Jiang, Xiaochun Zhou, Yucai Wei, Guan Wang, Long Gu, Yumin Li, Futian Tang, Daiying Zuo   +14 more
doaj   +2 more sources

Evaluation of the Key Advantages between Two Modalities of Boronophenylalanine Administration for Clinical Boron Neutron Capture Therapy Using an Animal Model

Cells, 2022
In clinical boron neutron capture therapy (BNCT), boronophenylalanine (BPA) administrations through one-step infusion (OSI) and two-step infusion (TSI) are the most widely used.
Yu-Chuan Lin, Yi-Jang Lee, Yi-Wei Chen, Shan-Ying Wang, Fong-In Chou   +4 more
doaj   +2 more sources

Fluorination of p-Boronophenylalanine

, 2001
Using tumor-seeking property of p-Boronophenylalanine (BPA), BPA was fluorinated with 18F, and 18F-p-10B-BPA has been used for positron emission tomography (PET).1 But, chemical and biological properties of the 18F-10B-BPA are not completely understood. There are following merits for synthesis of 19F-BPA.
Yutaka Mishima, Kazuo Yoshino, Tatsuo Ido, Yoshiro Inamoto, Hidetake Kakihana, Masamitsu Ichihashi   +5 more
core   +2 more sources

Increased cell killing effect in neutron capture enhanced proton beam therapy [PDF]

Scientific Reports
Thermal neutrons generated in the body during proton beam therapy (PBT) can be used to cause boron neutron capture reactions and have recently been proposed as neutron capture enhanced PBT (NCEPBT).
Shintaro Shiba, Takahiro Shimo, Masashi Yamanaka, Takayuki Yagihashi, Makoto Sakai, Tatsuya Ohno, Koichi Tokuuye, Motoko Omura   +7 more
doaj   +2 more sources

Capture of p-Boronophenylalanine by Melanin-Related Compounds: Complex Formation of p-Boronophenylalanine with L-Dopa

, 1993
There are the biologically proven facts that first, 10B-p-BPA accumulates 10B in melanoma cells, and second, the accumulation is not permanent. After reaching a saturation concentration, melanoma cells release boron1,2,3,4. The reason for the accumulation has been considered as follows. 1.
Y. Mori, T. Maruyama, Y. Mishima, H. Kakihana, K. Yoshino   +4 more
core   +2 more sources

ASSESSMENT OF THE EFFECT OF BORON NEUTRON CAPTURE THERAPY ON TUMOR CELL LINES AND PRIMARY EMBRYONIC CELL CULTURE

Сибирский онкологический журнал, 2021
Introduction. Boron neutron capture therapy (bnct) is a promising method for treating tumors, in particular, infiltrative malignant tumors, due to the selective destruction of tumor cells without damaging the surrounding normal tissues.
V. V. Kanygin, A. I. Kasatova, I. A. Razumov, E. L. Zavyalov, A. I. Kichigin, R. A. Mukhamadiyarov, S. Yu. Taskaev   +6 more
doaj   +1 more source

Boronophenylalanine-Fructose Complex

, 2020

core   +2 more sources