Results 151 to 160 of about 182,114 (282)

EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect

Cancer Science, EarlyView.
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu, Jingjia Chang, Zhiyong Li, Jin Wu, Pengfei Yu, Jingjing Zheng, Li Li, Jia Tao, Hao Wu, Yintao Li, Ming Liu   +10 more
wiley   +1 more source

Elevated IL‐4 and IL‐13 Expression in Hailey‐Hailey Disease: Evidence for Th2‐Mediated Pathogenesis and Targeted Treatment

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Hailey‐Hailey disease (HHD) is a rare autosomal dominant blistering disorder caused by mutations in the ATP2C1 gene, which impair keratinocyte adhesion through disrupted calcium signaling. While traditionally considered a structural defect, recent studies suggest that Th2‐mediated inflammation may exacerbate disease pathology ...
Simonetta I. Gaumond, Victoria Soto, Beatriz Abdo Abujamra, Franco Rongioletti, John A. McGrath, Ivan Jozic, Paolo Romanelli   +6 more
wiley   +1 more source

Treatment of Facial Dyskinesias with Botulinum Toxin

, 1985
Botulinum Toxin: Clostridium botulinum; 6 toxins -(A) stable, mechanism, interferes with acetylcholine release, binds to muscle locallyIC-F2a-treatment-of-blepharospasm-hemifacial-spasm-meige ...
Thomas J. Carlow, MD
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A 1% glycopyrronium bromide cream for topical treatment of severe primary axillary hyperhidrosis in adolescents: safety, local tolerability, systemic exposure and efficacy from an open‐label phase II study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Primary axillary hyperhidrosis (PAHH) results from dysregulation of the autonomic nervous system and typically begins during puberty. Treatment options for adolescents remain limited. This open‐label phase II study evaluated the safety, local tolerability, systemic exposure, and efficacy of 1% GPB cream over 8 weeks in
Rolf‐Markus Szeimies, Ana Kilic, Hubert Reich, Birgit Berger, Erik Schulze zur Wiesche, Leonie Litzka, Katharina Schramm, Susanne Heimstaedt‐Muskett, Clarissa Masur   +8 more
wiley   +1 more source

Real‐world evidence for the efficacy and tolerability of an isobutylamido‐thiazolyl‐resorcinol (Thiamidol)‐containing skincare regimen on facial hyperpigmentation and overall skin appearance: A multi‐centre study in 11 European countries

International Journal of Cosmetic Science, EarlyView.
A Thiamidol‐containing skincare regimen showed significant improvement in facial hyperpigmentation in a real‐world study across 11 European countries. The treatment led to a significant reduction in mMASI scores, enhanced overall skin condition and demonstrated high tolerability.
B. Schuster, T. Rogers, C. Vendruscolo, D. Roggenkamp, W. G. Philipp‐Dormston, F. Al‐Niaimi, S. Roussel, N. Kiss, H. Malik, D. Grozeva, K. S. Berger, C. Rauscher, L. Kolbe   +12 more
wiley   +1 more source

Prevalence and Characteristics of North American Indigenous Inflammatory Skin Disease: A Systematic Scoping Review

International Journal of Dermatology, EarlyView.
This scoping review synthesizes evidence on atopic dermatitis (AD), psoriasis, and hidradenitis suppurativa in North American Indigenous peoples across 49 studies and 63 clinical trials. Findings reveal consistently high disease burden in AD, marked underrepresentation in trials and guidelines, and five evidence‐based recommendations to advance ...
Rachel Asiniwasis, Jordanna Roesler, Amira Muftah, Aysha Lukmanji, McKenzie Van Eaton, Kavya Yatham, Erin Watson, Eric McMullen, Gregory Kost, Colton Jensen, Oluwatosin Odeshi, Anna Chacon, Dana Slape, Brittany Waller, Kelsey Hinther, Mamata Pandey, Carolyn Jack, Derek K. Chu   +17 more
wiley   +1 more source

Cosmetic Dermatology in Pregnancy and Lactation: A Risk–Benefit Framework for Clinical Practice

International Journal of Dermatology, EarlyView.
Summary of the safety profile of common cosmetic dermatology interventions during pregnancy and lactation. ABSTRACT Cosmetic dermatologic products and procedures are increasingly utilized by women of reproductive age, including those who are pregnant or lactating.
Timea Kovacs, Umer Nadir, Michael Goldenberg, Thomas E. Rohrer, Deirdre Hooper, George M. Jeha, Stanislav N. Tolkachjov   +6 more
wiley   +1 more source

Adverse Effects Linked to Counterfeit or Mishandled Botulinum Toxin Injections [PDF]

Distributed via the CDC Health Alert NetworkApril 23 2024, 11:00 AM ETCDCHAN-00507The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to alert clinicians about risks of counterfeit or mishandled

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Digital Communication in Paediatric Surgery Care: Meeting Parents' and Children's Fundamental Care Needs at Home

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore the fundamental care needs of parents and children in relation to surgery for a congenital malformation, and the nursing care provided to support these needs through digital communication. Design A qualitative descriptive study.
Matilda Wester Fleur, Helena Hansson, Pernilla Stenström, Charlotte Castor   +3 more
wiley   +1 more source

Botulinum Toxin in Children and Adolescents-A Comprehensive Review of Clinical Applications. [PDF]

Toxins (Basel)
Bašković M, Nikić Čižmek V, Buzuk J, Dujić B, Jurić D, Jurković K, Pehar K, Vuković S.   +7 more
europepmc   +1 more source