Results 211 to 220 of about 194,987 (288)

Bifidobacterium animalis BGI‐L99 Ameliorates Polycystic Ovary Syndrome by Modulating the Gut Microbiota‐Bile Acid‐IL‐22 Axis

iMetaMed, EarlyView.
Polycystic ovary syndrome (PCOS) is described as a complex endocrine‐metabolic disorder frequently accompanied by reproductive dysfunction and depression‐like behaviors. During PCOS progression, gut microbiota dysbiosis and systemic bile acid disturbances co‐occur, severely disrupting host immune and metabolic homeostasis. B.
Haoyu Wang, Weixuan Chen, Xiaofang Li, Xiaohong Lu, Tianli Liu, Jiarui Liang, Yajie Wang, Mengzhen Jia, Ruiyu Zhang, Yuzheng Gu, Jielei Zhu, Jiayi Ma, Zhinan Wu, Yiyi Zhong, Haifeng Zhang, Tao Yang, Liang Xiao, Zhigang Liu, Yuanqiang Zou   +18 more
wiley   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Triptolide Reduces Cholesterol Synthesis and Alleviates Neuroinflammation by Inhibiting CD33 in Alzheimer's Disease Development and Progression. [PDF]

Biology (Basel)
Yang Y, Ma Y, Wang P, Guan PP.
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Cardiometabolic Risk and Structural Brain Development in a Large Community-Based US Cohort. [PDF]

Hum Brain Mapp
Beck D, Westlye LT, Tamnes CK.
europepmc   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Genetically predicted stigmasterol and brain tumor risk: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Zhang B, Gao B, Yun P, Guo S, Liang C.
europepmc   +1 more source

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

Altered brain vascularization and transcriptional changes in embryos lacking ABCA1 support a role of cholesterol in brain angiogenesis. [PDF]

Front Cell Dev Biol
Becerra B, Ramírez-Herrera O, Barrios J, Madrid J, Calfunao S, Saavedra F, Romo-Toledo P, Juárez-Balarezo J, Casanova-Maldonado I, Arnold T, Palma V, Busso D, Santander N.   +12 more
europepmc   +1 more source

Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source