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Brain organoids and “organoid intelligence”: a neuroethical critique
Bioethics UpdateBackground: The article “Brain organoids and ‘organoid intelligence’” delves into the cutting-edge research surrounding the cultivation and utilization of brain organoids.
Alberto Carrara
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Vascularization of Human Brain Organoids [PDF]
Stem Cells, 2021 Abstract Human brain organoids are three-dimensional tissues that are generated in vitro from pluripotent stem cells and recapitulate the early development of the human brain. Brain organoids consist mainly of neural lineage cells, such as neural stem/precursor cells, neurons, astrocytes, and oligodendrocytes.
Takeshi K. Matsui +3 more
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Human Brain Organoids and Consciousness [PDF]
Neuroethics, 2022 AbstractThis article proposes a methodological schema for engaging in a productive discussion of ethical issues regarding human brain organoids (HBOs), which are three-dimensional cortical neural tissues created using human pluripotent stem cells. Although moral consideration of HBOs significantly involves the possibility that they have consciousness ...
Takuya Niikawa +3 more
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Mechanics of human brain organoids [PDF]
Physical Review E, 2020 Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs and, in particular, the early morphogenesis of the cortex.
Valentina Balbi +2 more
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Deciphering and reconstitution of positional information in the human brain development
Cell Regeneration, 2021 Organoid has become a novel in vitro model to research human development and relevant disorders in recent years. With many improvements on the culture protocols, current brain organoids could self-organize into a complicated three-dimensional ...
Yi-Fan Wang, Cong Liu, Peng-Fei Xu
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Applications of brain organoids in neurodevelopment and neurological diseases
Journal of Biomedical Science, 2021 A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. Brain organoid generation methods are abundant
Nan Sun +5 more
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Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue. [PDF]
, 2020 Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications.
Binette, Francois +6 more
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Methodologies for Generating Brain Organoids to Model Viral Pathogenesis in the CNS
Pathogens, 2021 (1) Background: The human brain is of interest in viral research because it is often the target of viruses. Neurological infections can result in consequences in the CNS, which can result in death or lifelong sequelae.
Hannah K. Hopkins +2 more
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Activity-induced instabilities of brain organoids [PDF]
The European Physical Journal E, 2021 AbstractWe present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked.
Thijssen, Kristian +2 more
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Brain organoids: Establishment and application
Frontiers in Cell and Developmental Biology, 2022 Brain organoids are produced by the differentiation of pluripotent stem cells under three-dimensional culture conditions by adding neurodevelopment-related regulatory signals. They are similar to the cell composition and anatomical structure of the brain, and can reflect the developmental process of the brain, as well as their physiology, pathology ...
Hao Chen, Xin Jin, Tie Li, Zhuang Ye
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