Results 21 to 30 of about 26,410 (296)

Genetic Modification of Brain Organoids [PDF]

Frontiers in Cellular Neuroscience, 2019
Brain organoids have become increasingly used systems allowing 3D-modeling of human brain development, evolution, and disease. To be able to make full use of these modeling systems, researchers have developed a growing toolkit of genetic modification techniques.
Fischer, J., Heide, M., Huttner, W.
openaire   +4 more sources

Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo [PDF]

, 2017
While the use of bioluminescent proteins for molecular imaging is a powerful technology to further our understanding of complex processes, fluorescent labeling with visible light fluorescent proteins such as GFP and RFP suffers from poor tissue ...
Blyth, Karen, Cheung, Eric C., Hock, Andreas K., Humpton, Timothy J., Lee, Pearl, McGhee, Ewan, Monteverde, Tiziana, Murphy, Daniel J., Paulus-Hock, Viola, Scopelliti, Alessandro, Strathdee, Douglas, Vousden, Karen H.   +11 more
core   +1 more source

The Application of Brain Organoids in Assessing Neural Toxicity

Frontiers in Molecular Neuroscience, 2022
The human brain is a complicated and precisely organized organ. Exogenous chemicals, such as pollutants, drugs, and industrial chemicals, may affect the biological processes of the brain or its function and eventually lead to neurological diseases ...
Pan Fan, YuanHao Wang, Min Xu, Xiao Han, Yan Liu, Yan Liu   +5 more
doaj   +1 more source

Construction of 3D in vitro models by bioprinting human pluripotent stem cells: Challenges and opportunities [PDF]

, 2019
Three-dimensional (3D) printing of biological material, or 3D bioprinting, is a rapidly expanding field with interesting applications in tissue engineering and regenerative medicine. Bioprinters use cells and biocompatible materials as an ink (bioink) to
Rosa, Alessandro, Salaris, Federico
core   +1 more source

High Throughput Blood-brain Barrier Organoid Generation and Assessment of Receptor-Mediated Antibody Transcytosis

Bio-Protocol, 2022
Targeting receptor-mediated transcytosis (RMT) is a successful strategy for drug delivery of biologic agents across the blood-brain barrier (BBB).
Elena Kassianidou, Claire Simonneau, Alina Gavrilov, Roberto Villaseñor   +3 more
doaj   +1 more source

Human brain organoid networks [PDF]

, 2021
AbstractHuman brain organoids replicate much of the cellular diversity and developmental anatomy of the human brain. However, the physiological behavior of neuronal circuits within organoids remains relatively under-explored. With high-density CMOS microelectrode arrays (26,400 electrodes) and shank electrodes (960 electrodes), we probed broadband and ...
Tal Sharf, Tjitse van der Molen, Stella M.K. Glasauer, Elmer Guzman, Alessio P. Buccino, Gabriel Luna, Zhouwei Cheng, Morgane Audouard, Kamalini G. Ranasinghe, Kiwamu Kudo, Srikantan S. Nagarajan, Kenneth R. Tovar, Linda R. Petzold, Andreas Hierlemann, Paul K. Hansma, Kenneth S. Kosik   +15 more
openaire   +1 more source

Opportunities for organoids as new models of aging. [PDF]

, 2018
The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use.
Antonica, Arora, Astashkina, Auger, Aw, Azpurua, Barbero, Barkauskas, Barkauskas, Barker, Bartfeld, Behjati, Belmin, Ben-Ze’ev, Bhumiratana, Blau, Blokzijl, Brack, Broutier, Busuttil, Caron, Caughey, Cerchiari, Chambers, Chang, Chaudhuri, Choi, Cornacchia, Crabb, Danahay, Dekkers, Dos Santos, Dye, Eiraku, Elahy, Engevik, Freedman, Gao, Garbe, Gjorevski, Greider, Gullapalli, Hannum, Hansen, Hegab, Heintz, Hibiya, Hohwieler, Horvath, Htwe, Huch, Huch, Jennifer L. Hu, Jones, Jung, Karthaus, Kolesky, Koo, Kwong, Lang, Lee, Lee, Levental, Li, Li, Lindahl, Linnemann, Liu, Lozito, Lyons, López-Otín, L’Heureux, Madden, Marciniak, Mark A. LaBarge, Matsui, Mattison, McElwee, Meerwaldt, Mertens, Messner, Michael E. Todhunter, Miller, Moore, Moore, Morizane, Murrow, Myers, Nalapareddy, Nasto, Nelson, Nevalainen, Nguyen-Ngoc, Nicholas, Noguchi, Ootani, O’Brien, Pageon, Pang, Parrinello, Pauli, Phillip, Plaks, Pribluda, Qian, Raja, Rangarajan, Rodriguez-Teja, Ruan, Sancar, Sato, Schütte, Seok, Simian, Singh, Squires, Stampfer, Stearns-Reider, Stojadinovic, Sun, Takasato, Takebe, Tan, Tanos, Toda, Todhunter, Turco, Tzatzalos, van Vliet, Vanhooren, Vernetti, Verzijl, Villadsen, Villeda, Voytik-Harbin, Watson, Williams, Wilson, Workman, Wu, Wylie, Xiang, Yilmaz, Zev J. Gartner, Zhang, Zhang   +145 more
core   +2 more sources

The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects

Frontiers in Cellular Neuroscience, 2021
Stroke is a neurological disease responsible for significant morbidity and disability worldwide. However, there remains a dearth of effective therapies.
Guini Song, Min Zhao, Hanmin Chen, Xiangyue Zhou, Cameron Lenahan, Yibo Ou, Yue He   +6 more
doaj   +1 more source

Human Organoids for Predictive Toxicology Research and Drug Development

Frontiers in Genetics, 2021
Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or adult tissue stem cells via a process of self-organization that results in the formation of organ-specific cell types.
Toshikatsu Matsui, Tadahiro Shinozawa
doaj   +1 more source

Brain organoid data synthesis and evaluation. [PDF]

Front Neurosci, 2023
IntroductionDatasets containing only few images are common in the biomedical field. This poses a global challenge for the development of robust deep-learning analysis tools, which require a large number of images. Generative Adversarial Networks (GANs) are an increasingly used solution to expand small datasets, specifically in the biomedical domain ...
Brémond-Martin C, Simon-Chane C, Clouchoux C, Histace A.   +3 more
europepmc   +5 more sources