Results 51 to 60 of about 26,410 (296)

Translational potential of human brain organoids [PDF]

Annals of Clinical and Translational Neurology, 2018
Abstract The recent technology of 3D cultures of cellular aggregates derived from human stem cells have led to the emergence of tissue‐like structures of various organs including the brain. Brain organoids bear molecular and structural resemblance with developing human brains, and have been demonstrated to recapitulate several ...
Sun A.X., Ng H.-H., Tan E.-K.
openaire   +2 more sources

Brain Organoids to Evaluate Cellular Therapies

Animals, 2022
Animal models currently used to test the efficacy and safety of cell therapies, mainly murine models, have limitations as molecular, cellular, and physiological mechanisms are often inherently different between species, especially in the brain. Therefore, for clinical translation of cell-based medicinal products, the development of alternative models ...
Ana Belén García-Delgado, Rafael Campos-Cuerva, Cristina Rosell-Valle, María Martin-López, Carlos Casado, Daniela Ferrari, Javier Márquez-Rivas, Rosario Sánchez-Pernaute, Beatriz Fernández-Muñoz   +8 more
openaire   +8 more sources

Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling [PDF]

, 2019
With 100 billion neurons and 100 trillion synapses, the human brain is not just the most complex organ in the human body, but has also been described as “the most complex thing in the universe.” The limited availability of human living brain tissue for ...
Allende, Almeida, Amenduni, Ananiev, Auger, Avior, Awad, Baarine, Barral, Basuodan, Bershteyn, Bhinge, Biedler, Biedler, Bilican, Bird, Birey, Bousquet, Boza-Moran, Brammer, Brawner, Brewer, Bridget E. Bax, Brodal, Camp, Carlessi, Carpenter, Carter, Chamberlain, Chambers, Chandrasekaran, Chang, Chesselet, Clevers, Cohen, Conti, Corti, Costero, Coyle, Crain, Cugola, Cunningham, Curchoe, Dang, Dario Pacitti, Dawson, DeFelipe, Denham, Denton, Dezonne, Di Lullo, Dickinson, Diez del Corral, Dingle, Djuric, Doerr, Doers, Dotti, Ebert, Edri, Efthymiou, Egawa, Eigentler, Eiraku, Eiraku, Elston, Eyal, Fernandez-Santiago, Fietz, Filis, Foo, Franco, Frotscher, Fuller, Garcez, Gaspard, Ge, Gharib, Giandomenico, Giulian, Goldman, Goldstein, Golgi, Gomes, Gonzalez-Cordero, Gordon, Gotz, Greene, Griesi-Oliveira, Gähwiler, Halevy, Hall, Hansen, Harrison, Harrison, Hartung, Haubensak, Havlicek, Herculano-Houzel, Hick, Higuchi, Higurashi, Hoadley, Hogue, Hogue, Howard, Huang, Hughes, Iefremova, Imura, Itskovitz-Eldor, Jaenisch, Jakel, Janesick, Jang, Jiang, Jiao, Jo, Johns, Kadoshima, Kelava, Kelava, Kim, Kirkeby, Kleinman, Knopfel, Ko, Komssi, Kovalevich, Kuff, Lancaster, Lancaster, Lancaster, Lancaster, Lange, LaVail, Lavazza, Lee, Lee, Lee, Lee, Lee, LePage, Li, Liddelow, Lingor, Liu, Liu, Liu, Liu, Lohle, Lojewski, Ma, Maden, Mansour, Marchetto, Mariani, Mariani, Mastrangelo, Matsui, Mattei, McCarthy, McGivern, McKinney, Mellios, Miranda, Miranda, Miranda, Mishra, Miyata, Mohan, Monzel, Muguruma, Muotri, Nayler, Ng, Nguyen, Nizzardo, Nzou, Okita, Ostergaard, Pacitti, Pacitti, Pahlman, Panicker, Park, Park, Pasca, Pasca, Pasca, Patitucci, Pauklin, Paşca, Pekny, Petros, Pham, Pleasure, Puschmann, Puschmann, Qian, Quadrato, Raja, Ramón y Cajal, Ramón y Cajal, Ramón y Cajal, Ramón y Cajal, Renner, Reubinoff, Reynolds, Riccardo Privolizzi, Ricciardi, Ring, Robertson, Roth, Rowitch, Sakaguchi, Sanchez-Danes, Sareen, Schuldiner, Schwab, Schwartz, Schwartz, Serio, Shcheglovitov, Shepherd, Shi, Shi, Shipley, Siegenthaler, Sloan, Sneddon, Soldner, Stan, Stubbs, Suga, Sun, Sun, Sun, Sutcliffe, Tachibana, Takahashi, Tang, Temple, Thomson, Tian, Tibbitt, Tiscornia, Tonge, Trilck, Ullrich, Ungrin, Urbach, Uusi-Rauva, Velasco, Vescovi, Vessoni, Vierbuchen, Villanueva, Waddington, Waddington, Walsh, Wang, Watanabe, Wataya, Whetsell, Williams, Wilson, Wood, Workman, Wu, Xu, Yakoub, Yakoub, Yamashita, Yang, Yang, Ye, Yin, Ying, Yoshida, Zhang, Zhang, Zhang, Zhu, Zhu, Zhu   +285 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

Neural Regeneration Research
Human brain development is a complex process, and animal models often have significant limitations. To address this, researchers have developed pluripotent stem cell-derived three-dimensional structures, known as brain-like organoids, to more accurately ...
Daiyu Hu, Yuanqing Cao, Chenglin Cai, Guangming Wang, Min Zhou, Luying Peng, Yantao Fan, Qiong Lai, Zhengliang Gao   +8 more
doaj   +1 more source

Generation of Human Blood Vessel and Vascularized Cerebral Organoids

Bio-Protocol, 2023
Brain organoids have been widely used to study diseases and the development of the nervous system. Many reports have investigated the application of brain organoids, but most of these models lack vascular structures, which play essential roles in brain ...
Xin Sun, Xiang Ju, Hong Zhao, Zhi You, Run Han, Zhen Luo   +5 more
doaj   +1 more source

Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections [PDF]

, 2018
Maternal Zika virus (ZIKV) infection during pregnancy is recognized as the cause of an epidemic of microcephaly and other neurological anomalies in human fetuses. It remains unclear how ZIKV accesses the highly vulnerable population of neural progenitors
Bakiasi, Grisilda, Bosch, Irene, Durbin, Ann F, Gehrke, Lee, Jaenisch, Rudolf, Li, Yun, Meyer, Aaron, Muffat, Julien, Omer, Attya, Richards, Edward   +9 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Beyond consciousness: Ethical, legal, and social issues in human brain organoid research and application

European Journal of Cell Biology
This study aims to provide a comprehensive review of the ethical, legal and social issues in human brain organoid research, with a view to different types of research and applications: in vitro research, transplantation into non-human animals, and ...
Masanori Kataoka, Takuya Niikawa, Naoya Nagaishi, Tsung-Ling Lee, Alexandre Erler, Julian Savulescu, Tsutomu Sawai   +6 more
doaj   +1 more source

Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays

Fluids and Barriers of the CNS, 2021
Background The pathways that control protein transport across the blood–brain barrier (BBB) remain poorly characterized. Despite great advances in recapitulating the human BBB in vitro, current models are not suitable for systematic analysis of the ...
Claire Simonneau, Martina Duschmalé, Alina Gavrilov, Nathalie Brandenberg, Sylke Hoehnel, Camilla Ceroni, Evodie Lassalle, Elena Kassianidou, Hendrik Knoetgen, Jens Niewoehner, Roberto Villaseñor   +10 more
doaj   +1 more source