Results 81 to 90 of about 26,410 (296)

Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids

Communications Biology
Brain organoid models have greatly facilitated our understanding of human brain development and disease. However, key brain cell types, such as microglia, are lacking in most brain organoid models.
Xianwei Chen, Guoqiang Sun, Lizhao Feng, E Tian, Yanhong Shi   +4 more
doaj   +1 more source

Cerebral Malaria Model Applying Human Brain Organoids

Cells, 2023
Neural injuries in cerebral malaria patients are a significant cause of morbidity and mortality. Nevertheless, a comprehensive research approach to study this issue is lacking, so herein we propose an in vitro system to study human cerebral malaria using cellular approaches.
Rita Silva-Pedrosa, Jonas Campos, Aline Marie Fernandes, Miguel Silva, Carla Calçada, Ana Marote, Olga Martinho, Maria Isabel Veiga, Ligia R. Rodrigues, António José Salgado, Pedro Eduardo Ferreira   +10 more
openaire   +4 more sources

Prenatal Drugs and Their Effects on the Developing Brain: Insights From Three-Dimensional Human Organoids

Frontiers in Neuroscience, 2022
Decades of research have unequivocally demonstrated that fetal exposure to both recreational and prescription drugs in utero negatively impacts the developing brain. More recently, the application of cutting-edge techniques in neurodevelopmental research
Isidora N. Stankovic, Dilek Colak, Dilek Colak   +2 more
doaj   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

On-site Cytology for Development of Patient-Derived Three-dimensional Organoid Cultures - A Pilot Study [PDF]

, 2017
BACKGROUND/AIM Development of patient-derived three-dimensional (3D) organoid cultures is an emerging technique in the field of precision oncology. We aimed to integrate on-site adequacy evaluation using cytology into the tumor organoid development ...
Sailer, Verena, Pauli, Chantal, Merzier, Elyze C, Mosquera, Juan Miguel, Beltran, Himisha, Rubin, Mark A, Rao, Rema A   +6 more
core   +1 more source

Purpose‐Adaptable Reinforced 3D Hyaluronic‐Acid Based Platform to Study Pathomechanisms of the Central Nervous System

Advanced Healthcare Materials, EarlyView.
Platform system to create biofabricated 3D spinal cord tissue models: Combining high resolution PCL fiber placement, a customized, hyaluronic acid‐based hydrogel, two cell types (spinal cord neurons and astrocytes) together with three distinct laminin isoforms allow the formation of functional cell–cell network interactions.
Nicoletta Murenu, Esra Tuerker, Anna‐Lena Wiessler, Jessica Faber, Ievgenii Liashenko, Jeanette Weigelt, Jörg Tessmar, Paul D. Dalton, Sibylle Jablonka, Mateo S. Andrade Mier, Carmen Villmann, Silvia Budday, Natascha Schaefer   +12 more
wiley   +1 more source

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases

Stem Cells International, 2017
In recent years, scientists have made great achievements in understanding the development of human brain and elucidating critical elements of stepwise spatiotemporal control strategies in neural stem cell specification lineage, which facilitates ...
NaiLi Wei, ZiFang Quan, Hailiang Tang, JianHong Zhu   +3 more
doaj   +1 more source

Approaches to vascularizing human brain organoids

PLOS Biology, 2023
A major challenge in brain organoid technologies is the lack of vasculature. In recent years, innovative approaches have been taken to meet this challenge. A 2020 paper published in PLOS Biology exemplifies the approaches used in this booming field.
openaire   +3 more sources

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source