Results 91 to 100 of about 2,545,594 (299)

Human brain organoid: trends, evolution, and remaining challenges

Neural Regeneration Research
Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and diseases. Although various studies and reviews have described developments and advancements in brain organoids, few ...
Minghui Li, Yuhan Yuan, Zongkun Hou, Shilei Hao, Liang Jin, Bochu Wang   +5 more
doaj   +1 more source

Modeling Alzheimer’s disease using human cell derived brain organoids and 3D models

Frontiers in Neuroscience
Age-related neurodegenerative diseases, like Alzheimer’s disease (AD), are challenging diseases for those affected with no cure and limited treatment options.
Sarah Fernandes, Jasmin S. Revanna, Joshua M. Pratt, Nicholas Hayes, M. Marchetto, F. H. Gage   +5 more
semanticscholar   +1 more source

Brain organoids and Ó?organoid intelligenceÓ�: a neuroethical critique

Bioethics Update
Background: The article “Brain organoids and ‘organoid intelligence’” delves into the cutting-edge research surrounding the cultivation and utilization of brain organoids. It highlights the potential of these miniaturized, simplified versions of the brain to revolutionize our understanding of neural development, disease mechanisms, and neurophysiology.
openaire   +2 more sources

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, EarlyView.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

Cerebral organoids exhibit mature neurons and astrocytes and recapitulate electrophysiological activity of the human brain

Neural Regeneration Research, 2019
Multiple protocols have been devised to generate cerebral organoids that recapitulate features of the developing human brain, including the presence of a large, multi-layered, cortical-like neuronal zone.
Abraam M Yakoub
doaj   +1 more source

Brain Organoid Computing -- an Overview

CoRR
The aim of this paper is to give an overview of brain organoid computing, its characteristics, challenges, as well as possible advantages for future applications in the field of artificial intelligence. An important part is the extensive bibliography covering all relevant aspects and questions on this topic. Brain organoids - three-dimensional in vitro
Yannic Talavera, Bernd Ulmann
openaire   +2 more sources

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy.

Cell Stem Cell
Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications for predicting response to therapy.
Tianping Peng, Xiujian Ma, Wei Hua, Changwen Wang, Youjun Chu, Meng Sun, Valentina Fermi, S. Hamelmann, K. Lindner, Chunxuan Shao, Julia Zaman, Weili Tian, Yue Zhuo, Yassin Harim, Nadja Stöffler, Linda Hammann, Qungen Xiao, Xiaoliang Jin, R. Warta, C. Lotsch, Xuran Zhuang, Yuan Feng, Minjie Fu, Xin Zhang, Jinsen Zhang, Hao Xu, Fufang Qiu, Liqian Xie, Yi Zhang, Wei Zhu, Zunguo Du, L. Salgueiro, Mark Schneider, F. Eichhorn, A. Lefevre, S. Pusch, V. Grinevich, M. Ratliff, S. Loges, L. Bunse, Felix Sahm, Yangfei Xiang, A. Unterberg, A. von Deimling, Michael Platten, C. Herold-Mende, Yonghe Wu, Haikun Liu, Ying Mao   +48 more
semanticscholar   +1 more source

Brain organoids and insights on human evolution [PDF]

F1000Research, 2019
Human brain organoids, generated from pluripotent stem cells, have emerged as a promising technique for modeling early stages of human neurodevelopment in controlled laboratory conditions. Although the applications for disease modeling in a dish have become routine, the use of these brain organoids as evolutionary tools is only now getting momentum ...
openaire   +4 more sources

Stretchable Microelectrode Arrays with Microneedles for Reliable Electrophysiological Recording of Human Heart and Brain Organoids

Advanced Science, EarlyView.
A stretchable 3D microelectrode array with microneedles (3D MN‐sMEA) enables stable, minimally destructive electrophysiological monitoring of 3D organoids. The wafer‐level stud‐bump bonding process facilitates high‐fidelity recordings of heart and cerebral organoids.
Eunyoung Jang, Saewoon Shin, Seul‐Gi Lee, Kiup Kim, Yoojeong Kim, Jun Sun, Il‐Joo Cho, Joseph A. Gogos, Jong‐Chan Park, C‐Yoon Kim, Hyunjoo J. Lee   +10 more
wiley   +1 more source