Results 81 to 90 of about 39,896 (297)
Generation of human vascularized brain organoids [PDF]
NeuroReport, 2018 The aim of this study was to vascularize brain organoids with a patient's own endothelial cells (ECs). Induced pluripotent stem cells (iPSCs) of one UC Davis patient were grown into whole-brain organoids. Simultaneously, iPSCs from the same patient were differentiated into ECs.Pham, Missy T, Pollock, Kari M, Rose, Melanie D, Cary, Whitney A, Stewart, Heather R, Zhou, Ping, Nolta, Jan A, Waldau, Ben +7 moreopenaire +4 more sourcesMapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience
Advanced Healthcare Materials, EarlyView.Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich +10 morewiley +1 more sourceInflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. [PDF]
, 2020 Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper ...Bao, Shideng, Bulek, Katarzyna, Cai, Gang, Chang, Christopher J, Chen, Xing, Fox, Paul L, Huang, Emina, Jackson, Mark W, Jia, Shang, Kalady, Matthew F, Li, Xiaoxia, Liao, Yun, Pizarro, Theresa T, Sen, Ganes C, Stark, George R, Tang, Fangqiang, Zhao, Junjie +16 morecore Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling [PDF]
, 2019 With 100 billion neurons and 100 trillion synapses, the human brain is not just the most complex organ in the human body, but has also been described as “the most complex thing in the universe.” The limited availability of human living brain tissue for ...Allende, Almeida, Amenduni, Ananiev, Auger, Avior, Awad, Baarine, Barral, Basuodan, Bershteyn, Bhinge, Biedler, Biedler, Bilican, Bird, Birey, Bousquet, Boza-Moran, Brammer, Brawner, Brewer, Bridget E. Bax, Brodal, Camp, Carlessi, Carpenter, Carter, Chamberlain, Chambers, Chandrasekaran, Chang, Chesselet, Clevers, Cohen, Conti, Corti, Costero, Coyle, Crain, Cugola, Cunningham, Curchoe, Dang, Dario Pacitti, Dawson, DeFelipe, Denham, Denton, Dezonne, Di Lullo, Dickinson, Diez del Corral, Dingle, Djuric, Doerr, Doers, Dotti, Ebert, Edri, Efthymiou, Egawa, Eigentler, Eiraku, Eiraku, Elston, Eyal, Fernandez-Santiago, Fietz, Filis, Foo, Franco, Frotscher, Fuller, Garcez, Gaspard, Ge, Gharib, Giandomenico, Giulian, Goldman, Goldstein, Golgi, Gomes, Gonzalez-Cordero, Gordon, Gotz, Greene, Griesi-Oliveira, Gähwiler, Halevy, Hall, Hansen, Harrison, Harrison, Hartung, Haubensak, Havlicek, Herculano-Houzel, Hick, Higuchi, Higurashi, Hoadley, Hogue, Hogue, Howard, Huang, Hughes, Iefremova, Imura, Itskovitz-Eldor, Jaenisch, Jakel, Janesick, Jang, Jiang, Jiao, Jo, Johns, Kadoshima, Kelava, Kelava, Kim, Kirkeby, Kleinman, Knopfel, Ko, Komssi, Kovalevich, Kuff, Lancaster, Lancaster, Lancaster, Lancaster, Lange, LaVail, Lavazza, Lee, Lee, Lee, Lee, Lee, LePage, Li, Liddelow, Lingor, Liu, Liu, Liu, Liu, Lohle, Lojewski, Ma, Maden, Mansour, Marchetto, Mariani, Mariani, Mastrangelo, Matsui, Mattei, McCarthy, McGivern, McKinney, Mellios, Miranda, Miranda, Miranda, Mishra, Miyata, Mohan, Monzel, Muguruma, Muotri, Nayler, Ng, Nguyen, Nizzardo, Nzou, Okita, Ostergaard, Pacitti, Pacitti, Pahlman, Panicker, Park, Park, Pasca, Pasca, Pasca, Patitucci, Pauklin, Paşca, Pekny, Petros, Pham, Pleasure, Puschmann, Puschmann, Qian, Quadrato, Raja, Ramón y Cajal, Ramón y Cajal, Ramón y Cajal, Ramón y Cajal, Renner, Reubinoff, Reynolds, Riccardo Privolizzi, Ricciardi, Ring, Robertson, Roth, Rowitch, Sakaguchi, Sanchez-Danes, Sareen, Schuldiner, Schwab, Schwartz, Schwartz, Serio, Shcheglovitov, Shepherd, Shi, Shi, Shipley, Siegenthaler, Sloan, Sneddon, Soldner, Stan, Stubbs, Suga, Sun, Sun, Sun, Sutcliffe, Tachibana, Takahashi, Tang, Temple, Thomson, Tian, Tibbitt, Tiscornia, Tonge, Trilck, Ullrich, Ungrin, Urbach, Uusi-Rauva, Velasco, Vescovi, Vessoni, Vierbuchen, Villanueva, Waddington, Waddington, Walsh, Wang, Watanabe, Wataya, Whetsell, Williams, Wilson, Wood, Workman, Wu, Xu, Yakoub, Yakoub, Yamashita, Yang, Yang, Ye, Yin, Ying, Yoshida, Zhang, Zhang, Zhang, Zhu, Zhu, Zhu +285 morecore +2 more sourcesDevelopment of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System
Advanced Healthcare Materials, EarlyView.ABSTRACT
The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith +7 morewiley +1 more sourceReliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening
Nature CommunicationsBrain organoids offer unprecedented insights into brain development and disease modeling and hold promise for drug screening. Significant hindrances, however, are morphological and cellular heterogeneity, inter-organoid size differences, cellular stress, Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan +25 moredoaj +1 more sourceCerebral Malaria Model Applying Human Brain Organoids
Cells, 2023 Neural injuries in cerebral malaria patients are a significant cause of morbidity and mortality. Nevertheless, a comprehensive research approach to study this issue is lacking, so herein we propose an in vitro system to study human cerebral malaria using cellular approaches.Rita Silva-Pedrosa, Jonas Campos, Aline Marie Fernandes, Miguel Silva, Carla Calçada, Ana Marote, Olga Martinho, Maria Isabel Veiga, Ligia R. Rodrigues, António José Salgado, Pedro Eduardo Ferreira +10 moreopenaire +4 more sourcesDiels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering
Advanced Healthcare Materials, EarlyView.This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...Sanne M. van de Looij, Antonia G. Vasilopoulou, Lennard Spauwen, Antoinette van den Dikkenberg, Jasmijn V. Korpershoek, Mylene de Ruijter, Jos Malda, Bas G. P. van Ravensteijn, Tina Vermonden +8 morewiley +1 more sourceChromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells. [PDF]
, 2019 In the mammalian genome, the clustered protocadherin (cPCDH) locus provides a paradigm for stochastic gene expression with the potential to generate a unique cPCDH combination in every neuron.Allegue, Catarina, Almenar-Queralt, Angels, Bohaciakova, Dasa, Chaves, Rodrigo S, Chen, Andrew G, Dittrich, Marcus, Driscoll, Shawn P, El Hajj, Nady, Fong, Lauren K, Garcia-Bassets, Ivan, Goldstein, Lawrence SB, Hruska-Plochan, Marian, Kim, Hong Sook, Kohlnhofer, Bridget, Ma, Qi, Mackintosh, Carlos, Marsala, Martin, Merkurjev, Daria, Navarro, Michael, Tadokoro, Takahiro, Woodruff, Grace, Young, Jessica E +21 morecore
