Results 121 to 130 of about 23,134 (164)

Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids. [PDF]

Genome Res
Umans BD, Gilad Y.
europepmc   +1 more source

Brain organoids: building higher-order complexity and neural circuitry models. [PDF]

Trends Biotechnol
Maisumu G, Willerth S, Nestor MW, Waldau B, Schülke S, Nardi FV, Ahmed O, Zhou Y, Durens M, Liang B, Yakoub AM.   +10 more
europepmc   +1 more source

Hypoxia-ischemia and sexual dimorphism: modeling mitochondrial dysfunction using brain organoids. [PDF]

Cell Biosci
Gaston-Breton R, Disdier C, Hagberg H, Mabondzo A.   +3 more
europepmc   +1 more source

Human brain organoids for understanding substance use disorders. [PDF]

Drug Metab Pharmacokinet
Li K, Gu L, Cai H, Lu HC, Mackie K, Guo F.   +5 more
europepmc   +1 more source

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Polarizing brain organoids

Nature Biotechnology, 2019
Human brain organoids are endowed with regional topography using engineered signaling centers.
Yuki Miura, Sergiu P. Pașca
openaire   +2 more sources

Brain organoids restore cortical damage

Cell Stem Cell, 2023
Cortical damage is irreparable and poses a challenge to regenerative medicine. Whether brain organoids can compensate for injured brain regions remains unclear. In this issue of Cell Stem Cell, Jgamadze et al. report that human forebrain organoids transplanted into the rat visual system show long-term structural connectivity and the restoration of ...
Nazlican, Altinisik, Dhanasekaran, Rathinam, Minh, Tran, Jay, Gopalakrishnan   +3 more
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Interdisciplinary approaches to brain organoid biology

Folia Pharmacologica Japonica, 2023
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been widely used as materials for regenerative medicine and for modeling development and disease because of their pluripotency to differentiate into all cell types of the body.
Tomoki, Kodera, Fumitaka, Osakada
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Microinstrumentation for Brain Organoids

Advanced Healthcare Materials
AbstractBrain organoids are three‐dimensional aggregates of self‐organized differentiated stem cells that mimic the structure and function of human brain regions. Organoids bridge the gaps between conventional drug screening models such as planar mammalian cell culture, animal studies, and clinical trials.
Devan Patel, Saniya Shetty, Chris Acha, Itzy E. Morales Pantoja, Alice Zhao, Derosh George, David H. Gracias   +6 more
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Modeling traumatic brain injury with human brain organoids

Current Opinion in Biomedical Engineering, 2020
Traumatic brain injury (TBI) remains a prominent public health concern despite several decades of attempts to develop therapies for the associated neurological and cognitive deficits. Effective models of this condition are imperative for better defining its pathophysiology and testing therapeutics.
Dennis Jgamadze, Victoria E. Johnson, John A. Wolf, D. Kacy Cullen, Hongjun Song, Guo-li Ming, Douglas H. Smith, H. Isaac Chen   +7 more
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