Results 221 to 230 of about 39,896 (297)

Modeling neurodegenerative diseases with brain organoids: from development to disease applications. [PDF]

Front Cell Dev Biol
Larriba-González T, García-Martín M, Ojeda-Hernández DD, Rincón-Cerrada P, Martín-Blanco L, Benito-Martín MS, Selma-Calvo B, de la Fuente-Martín S, Matias-Guiu JA, Matias-Guiu J, Gómez-Pinedo U.   +10 more
europepmc   +1 more source

Proteomic dataset of MECP2-deficient and wild-type human brain organoids under spaceflight and ground conditions. [PDF]

Sci Data
Martins AMA, Biagi DG, Tsu BL, de Saldanha da Gama Fischer J, Coelho LBV, Carvalho PC, Muotri AR.   +6 more
europepmc   +1 more source

In Vitro Reconstruction of Axonal Heat Sensing with a Photothermal Nerve‐on‐a‐Chip

Small, EarlyView.
A photothermal nerve‐on‐a‐chip platform is presented that enables precise, localized heating of sensory axons with simultaneous electrical recording. The system reveals millisecond‐scale dynamics of heat‐evoked neural activity and provides a new approach to study how temperature‐dependent ion channel behavior is translated into axonal firing.
Koji Sakai, Yujiro Tanaka, Riku Takahashi, Toichiro Goto, Yosuke Mizuno, Taiki Otomo, Aya Tanaka   +6 more
wiley   +1 more source

Clonidine prevents radiation-induced cell death in human brain organoids. [PDF]

Sci Rep
Lundberg M, Samudyata, Koskuvi M, Gkogka A, Nikpour M, Çelik M, Smedler E, Stenerlöw B, Lönnqvist PA, Schalling M, Sellgren CM.   +10 more
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Modeling Glioblastoma with Brain Organoids: New Frontiers in Oncology and Space Research. [PDF]

Int J Mol Sci
Begani L, Remore LG, Ragosta S, Rizzaro MD, Guarnaccia L, Alotta GA, Riboni L, Miozzo MR, Barilla E, Gaudino C, Locatelli M, Garzia E, Marfia G, Navone SE.   +13 more
europepmc   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

GLUT1-DS Brain Organoids Exhibit Increased Sensitivity to Metabolic and Pharmacological Induction of Epileptiform Activity. [PDF]

Pharmaceuticals (Basel)
Lengacher L, Lengacher S, Magistretti PJ, Finsterwald C.   +3 more
europepmc   +1 more source

Liminal Bioethics for Liminal Statuses: A New Method for Analysing Novel Biological Entities

Bioethics, EarlyView.
ABSTRACT Novel biological entities such as cell lines and organoids do not typically fit into established conceptual categories, such as ‘human’ or ‘nonhuman’, ‘gift’ or ‘property’. This makes developing robust ethical principles or policy solutions difficult.
Michael Wee, Ilina Singh
wiley   +1 more source

Human Brain Organoids: Development and Applications. [PDF]

J Microbiol Biotechnol
Hongxi W, Ruting W, Yiyang L, Qinglian H, Jibing C, Feng J.   +5 more
europepmc   +1 more source