Results 241 to 250 of about 2,545,594 (299)

Clonidine prevents radiation-induced cell death in human brain organoids. [PDF]

Sci Rep
Lundberg M, Samudyata, Koskuvi M, Gkogka A, Nikpour M, Çelik M, Smedler E, Stenerlöw B, Lönnqvist PA, Schalling M, Sellgren CM.   +10 more
europepmc   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1934-1941, August 2026.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

Modeling Glioblastoma with Brain Organoids: New Frontiers in Oncology and Space Research. [PDF]

Int J Mol Sci
Begani L, Remore LG, Ragosta S, Rizzaro MD, Guarnaccia L, Alotta GA, Riboni L, Miozzo MR, Barilla E, Gaudino C, Locatelli M, Garzia E, Marfia G, Navone SE.   +13 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, Volume 101, Issue 4, Page 1877-1903, August 2026.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

Proteomic dataset of MECP2-deficient and wild-type human brain organoids under spaceflight and ground conditions. [PDF]

Sci Data
Martins AMA, Biagi DG, Tsu BL, de Saldanha da Gama Fischer J, Coelho LBV, Carvalho PC, Muotri AR.   +6 more
europepmc   +1 more source

Single‐Nucleus Multiomic Analysis Reveals Immune–Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV‐Associated Neurocognitive Disorders

Glia, Volume 74, Issue 8, August 2026.
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez, Anelia Horvath, Luke Johnson, Tatiana Pushkarsky, Larisa Dubrovsky, Daria Starosyla, Ashley Bastin, Dmitri Sviridov, Michael Bukrinsky   +8 more
wiley   +1 more source

GLUT1-DS Brain Organoids Exhibit Increased Sensitivity to Metabolic and Pharmacological Induction of Epileptiform Activity. [PDF]

Pharmaceuticals (Basel)
Lengacher L, Lengacher S, Magistretti PJ, Finsterwald C.   +3 more
europepmc   +1 more source

Metabolic Assessment in Human Pluripotent Stem Cell‐Derived Cerebral Organoids Using HR‐MAS NMR Spectroscopy

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
We present a direct method for evaluating metabolism in intact hPSC‐derived cerebral organoids (COs) via HR‐MAS 1H‐NMR spectroscopy. This approach suggests that COs exhibit a metabolic profile similar to in vivo human fetal brain, with high levels of lactate and hTau, low levels of NAA, and equimolar levels of Glu and Gln.
Maria Alejandra Castilla Bolanos, Vorapin Chinchalongporn, Rajshree Ghosh Biswas, Colleen Bailey, Maggie Wu, Ronald Soong, Fermisk Saleh, Andre Simpson, Carol Schuurmans, Jamie Near   +9 more
wiley   +1 more source

Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids. [PDF]

Nat Commun
Bertin M, Todorov H, Frank S, Käseberg S, Menon R, Gabassi E, Foerster C, Bobon N, Furlanetto F, Soliman A, Ibrahim HMB, Engelhardt V, Birschmann L, Brennenstuhl H, Lohrer B, Mas-Sanchez A, Cesare E, Winter J, Krummeich J, Winkler J, Winner B, Weis E, Diederich S, Luck K, Lunt P, Gerber S, Baumann P, Elvassore N, Berninger B, Basilicata MF, Schweiger S, Falk S, Karow M.   +32 more
europepmc   +1 more source