Results 241 to 250 of about 39,896 (297)

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

Cell Proliferation, EarlyView.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu   +10 more
wiley   +1 more source

Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids. [PDF]

Sci Rep
Klockner I, Yeturi M, Rust TE, Stein JL, Zylka MJ.   +4 more
europepmc   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, EarlyView.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

Human brain organoids: an innovative model for neurological disorder research and therapy. [PDF]

Front Cell Neurosci
Li H, Zhu J, Li J, Wu Y, Luo C, Huang Y, Wu J, Liu W, Wang H, Mo Z.   +9 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems. [PDF]

Adv Sci (Weinh)
Kshirsagar A, Mnatsakanyan H, Kulkarni S, Guo J, Cheng K, Ofria LD, Bohra O, Sagar R, Mahairaki V, Badr CE, Kathuria A.   +10 more
europepmc   +1 more source

Bringing cellular clarity to the cortical component of ALS with a high‐density multi‐electrode array system

The FEBS Journal, EarlyView.
High density multi‐electrode (HD‐MEA) systems enable detailed investigation of healthy and diseased brains in 2D and 3D. Here, we summarise the significance of single‐cell electrophysiology, advantages of the MEA systems with high spatio‐temporal resolution and a large number of recording sites, enabling complex network analysis.
Zehra Yagmur Erol, Christopher Quintanilla, P. Hande Ozdinler   +2 more
wiley   +1 more source

Beyond Structure: Next-Generation Electrophysiological Platforms for Functional Brain Organoids. [PDF]

Int J Stem Cells
Cha JH, Kim K, Cho IJ.
europepmc   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning. [PDF]

iScience
Turpin-Moreno I, Modrego A, Martí-Sarrias A, García-González L, Ortega-Gasco A, Haeb AC, Pareja R, Soriano J, Ruiz N, Peñuelas-Haro I, Espinet E, Navarro A, Tornero D, Lao O, Acosta S.   +14 more
europepmc   +1 more source