Results 251 to 260 of about 2,545,594 (299)

Testican‐1‐MMP axis in tumour extracellular matrix (ECM) remodelling: interaction dynamics analysis and an in silico perspective

The Journal of Pathology, Volume 269, Issue 4-5, Page 433-445, August 2026.
Abstract The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican‐1 (SPOCK1), an excretory matricellular proteoglycan, is suggested to exert a role in the facilitation of ECM remodelling processes through interacting ...
Sepideh Youssefi, Kiarash Saleki, Prerna Kadam, Amirreza Mazloomi, Abhik Mukherjee, Lodewijk V Dekker, Abdolrahman S Nateri   +6 more
wiley   +1 more source

Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley   +1 more source

iPSC-induced multilineage liver organoids, small intestinal organoids and brain organoids sustain pangenotype hepatitis E virus propagation. [PDF]

Gut
Liu F, Liu T, Wu X, Yu Z, Tong J, Wang L, Zhao C, Nie J, Wang Y, Wang K, Bai L, Xia P, Wang K, Wei G, Zheng ZZ, Wu D, Huang W, Wang L.   +17 more
europepmc   +1 more source

CEP290 deficiency disrupts ciliary axonemal architecture in human iPSC-derived brain organoids. [PDF]

J Cell Sci
Eschment M, Mercey O, Aarts EM, Perego L, Figueiro-Silva J, Mennel M, Abidi A, Generali M, Rauch A, Guichard P, Hamel V, Bachmann-Gagescu R.   +11 more
europepmc   +1 more source

Human brain organoids: an innovative model for neurological disorder research and therapy. [PDF]

Front Cell Neurosci
Li H, Zhu J, Li J, Wu Y, Luo C, Huang Y, Wu J, Liu W, Wang H, Mo Z.   +9 more
europepmc   +1 more source

Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids. [PDF]

Sci Rep
Klockner I, Yeturi M, Rust TE, Stein JL, Zylka MJ.   +4 more
europepmc   +1 more source

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Microinstrumentation for Brain Organoids

Advanced Healthcare Materials
Brain organoids are three‐dimensional aggregates of self‐organized differentiated stem cells that mimic the structure and function of human brain regions.
Devang Patel, Saniya Shetty, Chris Acha, I. M. Pantoja, Alice Zhao, Derosh George, D. Gracias   +6 more
semanticscholar   +3 more sources

Polarizing brain organoids

Nature Biotechnology, 2019
Human brain organoids are endowed with regional topography using engineered signaling centers.
Yuki Miura, Sergiu P. Pașca
openaire   +2 more sources