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Vascular network-inspired diffusible scaffolds for engineering functional mid-brain organoids
Cell Stem CellSUMMARY Organoids, 3D organ-like tissue cultures derived from stem cells, show promising potential for developmental biology, drug discovery, and regenerative medicine. However, the function and phenotype of current organoids, especially neural organoids,
Hongwei Cai +9 more
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Brain organoids-on-chip for neural diseases modeling: History, challenges and trends
Journal of Pharmaceutical AnalysisBrain organoid-on-chip platforms have emerged as groundbreaking tools in neural disease modeling and drug discovery, offering a unique and highly accurate simulation of human organ physiology and function compared with traditional cell culture systems ...
Hongyong Zhang +3 more
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Assembling human brain organoids
Science, 2019Three-dimensional assembloids can be used to study human development and ...
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Brain Organoid Computing for Artificial Intelligence
2023Abstract Brain-inspired hardware emulates the structure and working principles of a biological brain and may address the hardware bottleneck for fast-growing artificial intelligence (AI). Current brain-inspired silicon chips are promising but still limit their power to fully mimic brain function for AI computing. Here,
Hongwei, Cai +8 more
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Interdisciplinary approaches to brain organoid biology
Folia Pharmacologica Japonica, 2023Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been widely used as materials for regenerative medicine and for modeling development and disease because of their pluripotency to differentiate into all cell types of the body.
Tomoki, Kodera, Fumitaka, Osakada
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Brain organoid-on-a-chip to create multiple domains in forebrain organoids
2023Abstract Brain organoids are three-dimensionally reconstructed brain tissue derived from pluripotent stem cells in vitro. 3D tissue cultures have opened new avenues for exploring development and disease modeling. However, some physiological conditions, including signaling gradients in 3D cultures, have not yet been easily achieved. Here,
Yuan-Chen Tsai +11 more
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Brain organoids get vascularized
Nature Biotechnology, 2018Transplantation of cerebral organoids into the mouse brain overcomes some limitations of in vitro systems.
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Application of brain organoids in neurodevelopmental disorders
Biochemical and Biophysical Research CommunicationsUnderstanding the etiology of human neurological and psychiatric disorders remains challenging due to species-specific genomic architectures, prolonged developmental timelines, and the unique cytoarchitectural features of the human brain, which are inadequately replicated in conventional animal models.
Chao, Zhao +4 more
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Non-invasive label-free imaging analysis pipeline for in situ characterization of 3D brain organoids
Scientific ReportsBrain organoids provide a unique opportunity to model organ development in a system similar to human organogenesis in vivo. Brain organoids thus hold great promise for drug screening and disease modeling.
Caroline E. Serafini +7 more
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