Results 201 to 210 of about 27,210 (261)

Human Prostate Cell Lines: Derivation, Molecular Characteristics and Appropriate Use

The Prostate, EarlyView.
ABSTRACT Background Research on prostate cancer and benign prostatic hyperplasia depends on a small number of immortalized human cell lines established between 1977 and 2001, most of them from advanced metastatic disease. The cell lines differ from one another in androgen receptor status, prostate‐specific antigen secretion, p53 status, karyotype and ...
Hamza Abohamra, Keenau Mark Pearce
wiley   +1 more source

How human-derived brain organoids are built differently from brain organoids derived from genetically-close relatives: a multi-scale hypothesis.

Soft Matter
Zhang T, Gupta S, Lancaster MA, Schwarz JM.   +3 more
europepmc   +1 more source

Preconfigured neuronal firing sequences in human brain organoids. [PDF]

Nat Neurosci
van der Molen T, Spaeth A, Chini M, Hernandez S, Kaurala GA, Schweiger HE, Duncan C, McKenna S, Geng J, Lim M, Bartram J, Gänswein T, Dendukuri A, Zhang Z, Gonzalez-Ferrer J, Bhaskaran-Nair K, Morson AL, Harder CRK, Petzold LR, Alam El Din DM, Laird J, Schenke M, Smirnova L, Colquitt BM, Mostajo-Radji MA, Hansma PK, Teodorescu M, Hierlemann A, Hengen KB, Hanganu-Opatz IL, Kosik KS, Sharf T.   +31 more
europepmc   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

Comparative Evaluation of hiPSC-Derived Brain Organoids as Platforms for Assessing Thyroid Hormone System Disrupting Chemicals. [PDF]

Cells
Fernandez Vallone V, Hellwig L, Rijntjes E, von Kügelgen N, Sane R, Opitz R, Kühnen P, Köhrle J, Mergenthaler P, Stachelscheid H.   +9 more
europepmc   +1 more source

Electrochemical and Biological Evaluation of Patterned TiO2@TiC‐Nanowires for Bio‐Interface Electrode

Small, EarlyView.
This study introduces a room‐temperature process to fabricate patterned TiO2@TiC core–shell nanowires, merging the biocompatibility of TiO2‐NWs with the high conductivity of TiC. Through sputtering pressure and time modulation, the nanowires morphology and electrochemical properties are tuned, enabling enhanced capacitance, stability, and guided ...
Roaa Sait, Shofarul Wustoni, Nabeel Aslam, Camelia Florica, Andrea Diaz‐Gaxiola, Valentina‐Elena Musteata, Mohammed K. Drad, Stephen Ghandour, Georgian Melinte, Yaping Zhang, Mohammed Nejib Hedhili, Ahad Ali Syed, Menouer Saidani, Shahryar Khattak, Imed Eddine‐Gallouzi, Sahika Inal, Hala Aljawhari   +16 more
wiley   +1 more source

CASPR2 Autoimmune Antibodies Induce Neuronal Hyperactivity in Human Brain Organoids. [PDF]

J Neurochem
Oliveira AR, Cammarata G, Seabra C, Cardoso AM, Santos HJ, Guedes J, Sequeira D, Santos JMM, Oliveira G, Cardoso AL, Fernandes D, Leite MI, Coutinho E, Carvalho AL, Ferreira L, Peça J.   +15 more
europepmc   +1 more source

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

Ethical concerns about embodied brain organoids shaped by foundational distinctions and perceptions of consciousness. [PDF]

Sci Rep
Boyd JL, Jensen EA, Jensen AM, Lipshitz N.   +3 more
europepmc   +1 more source

3D Nanoprinted Structures Promote Robust Integration of Brain Organoids into Topography‐Guided Neuronal Networks

Small, EarlyView.
Dedicated cultivation platforms facilitate the implementation of brain organoids in guided neuronal networks. Fabrication is enabled by two‐photon polymerization‐based 3D nanoprinting (3DN) and allows for cultivation in standard 12‐well plates. Fine features, namely slopes, funnels, rods, steps, and walls, facilitate and promote organoid positioning ...
Malte Siegmund, Tobias Müller, Emma Wollesen, Kim Krieg, Jack Muse, Jan Hahn, Maya Luongo, Wolfgang J. Parak, Ole Pless, Robert Zierold, Robert H. Blick   +10 more
wiley   +1 more source