Results 201 to 210 of about 2,545,594 (299)

Mechanical impact on neural stem cell lineage decisions in human brain organoids. [PDF]

EMBO Rep
Lampersperger H, Tranchina M, Meth B, Han D, Nayebzadeh N, Reiter N, Kuth S, Lorke M, Boccaccini AR, Budday S, Karow M, Falk S.   +11 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Brain organoid technology in melanoma metastasis to the brain

Melanoma Management
Rabinowitz, Grace, Schuldt, Braxton R., Ji, Andrew L., Gulati, Nicholas   +3 more
openaire   +3 more sources

Addressing the Challenges of Translating LRRK2 Biology into Disease‐Modifying Therapies: The LRRK2 Investigative Therapeutics Exchange Initiative

Movement Disorders, EarlyView.
Esther Sammler, Francesca Tonelli, Michelle Durborow, Jim McNasby, Todd Sherer, Mahmood Ahmed, Stevan W. Djuric, Kalpana Merchant, Alastair Reith, Darryle Schoepp, Christine Klein, Shalini Padmanabhan, Dario R. Alessi   +12 more
wiley   +1 more source

Bringing cellular clarity to the cortical component of ALS with a high‐density multi‐electrode array system

The FEBS Journal, EarlyView.
High density multi‐electrode (HD‐MEA) systems enable detailed investigation of healthy and diseased brains in 2D and 3D. Here, we summarise the significance of single‐cell electrophysiology, advantages of the MEA systems with high spatio‐temporal resolution and a large number of recording sites, enabling complex network analysis.
Zehra Yagmur Erol, Christopher Quintanilla, P. Hande Ozdinler   +2 more
wiley   +1 more source

How human-derived brain organoids are built differently from brain organoids derived from genetically-close relatives: a multi-scale hypothesis.

Soft Matter
Zhang T, Gupta S, Lancaster MA, Schwarz JM.   +3 more
europepmc   +1 more source

Vascularized human brain organoids as a model of the brain-peripheral axis in HIV-1 neuropathogenesis. [PDF]

Sci Rep
Selvam S, Dos Reis RS, Wagner MCE, Krishnakumar R, Keshavarz K, Ebrahimkhani MR, Ayyavoo V.   +6 more
europepmc   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Female metabolic resilience and male-biased protein quality defects under hypoxia in human brain organoids. [PDF]

iScience
Gaston-Breton R, Bouzid A, Antipushina E, Costa N, Sarkadi B, Apati A, Harati R, Sharaev M, Armengaud J, Disdier C, Hamoudi R, Mabondzo A.   +11 more
europepmc   +1 more source

20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy

Journal of Microscopy, EarlyView.
Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford, Colette J. Mustard, Nicole Brace, Antonia L. Pritchard   +3 more
wiley   +1 more source