Results 201 to 210 of about 39,896 (297)

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient-Derived Brain Organoids. [PDF]

Adv Sci (Weinh)
Zhang Z, Yangzom T, Lu N, Deng S, Xiao X, Yang G, Liang KX.   +6 more
europepmc   +1 more source

Bile Acids as Selective Gatekeepers of Dietary Lipid Absorption: Mechanistic Insights and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Their work provides evidence in murine models that the bile acid pool may function as a tunable filter whose selectivity for different fatty acids depends on bile acid concentration and composition. This framework suggests a selective decoupling of the absorption of excessive saturated fatty acids (SFAs) from that of beneficial polyunsaturated
Hao Wang, Yue Yang, Yulong Zhang, Yinling Li, Xuemei Ma, Haitao Wang   +5 more
wiley   +1 more source

How human-derived brain organoids are built differently from brain organoids derived from genetically-close relatives: a multi-scale hypothesis.

Soft Matter
Zhang T, Gupta S, Lancaster MA, Schwarz JM.   +3 more
europepmc   +1 more source

Increased reproducibility of brain organoids through controlled fluid dynamics. [PDF]

EMBO Rep
Aiello G, Nemir M, Vidimova B, Ramel C, Viguie J, Ravera A, Wrzesinski K, Bagni C.   +7 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Oropouche virus infects human neural progenitor cells and alters the growth of brain organoids. [PDF]

iScience
Albert A, Couture L, Piumi F, Lebon S, Gressens P, Coulpier M, Amara A, El Ghouzzi V, Meertens L.   +8 more
europepmc   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Proteomic profiling of brain organoids and extracellular vesicles identifies early Alzheimer's disease biomarkers and drug response heterogeneity. [PDF]

Alzheimers Dement
Boyd RJ, Dong D, Sagar R, Iliuk A, Ahmed W, Androni X, Porsteinsson AP, Rosenberg PB, Lyketsos CG, Witwer KW, Mahairaki V.   +10 more
europepmc   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

The emergence of electrical activity in human brain organoids. [PDF]

Stem Cell Reports
Mancinelli S, Bariselli S, Lodato S.
europepmc   +1 more source