Results 181 to 190 of about 39,896 (297)

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids. [PDF]

Nat Commun
Menacho C, Okawa S, Álvarez-Merz I, Wittich A, Muñoz-Oreja M, Lisowski P, Martín ML, Pentimalli TM, Zakin S, Thevandavakkam M, Jerred C, Lickfett S, Petersilie L, Rybak-Wolf A, Seibt A, Herebian D, Inak G, Brodesser S, Zaliani A, Mlody B, Donnelly J, Woleben K, Soriano FX, Fernandez-Checa JC, Ventura N, Cambridge S, Mayatepek E, Spinazzola A, Schuelke M, Rajewsky N, Rossi A, Peralvarez-Marin A, Distelmaier F, Perlstein E, Holt IJ, Puighermanal E, Pless O, Rose CR, Del Sol A, Prigione A.   +39 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Ethical concerns about embodied brain organoids shaped by foundational distinctions and perceptions of consciousness. [PDF]

Sci Rep
Boyd JL, Jensen EA, Jensen AM, Lipshitz N.   +3 more
europepmc   +1 more source

Integrative genomic and spatial transcriptomic analysis elucidates the oligodendrocyte‐mediated etiology of epileptic cortical thinning

Epilepsia Open, EarlyView.
Abstract Objective Focal epilepsy is characterized by progressive cortical thinning, particularly within limbic structures; however, whether this atrophy reflects acquired seizure‐induced damage or shared genetic predisposition remains unresolved. Methods We integrated genome‐wide association study (GWAS) summary statistics from the ILAE Consortium ...
Dingyuan Zhang, Qianqian Zhang, Guangming Li, Lingting Yu, Yanling Ma, Xiaoli Hong, Yujie Kui, Shanshan Cai, Jianguang Sun, Zechao Zhu   +9 more
wiley   +1 more source

Mechanical impact on neural stem cell lineage decisions in human brain organoids. [PDF]

EMBO Rep
Lampersperger H, Tranchina M, Meth B, Han D, Nayebzadeh N, Reiter N, Kuth S, Lorke M, Boccaccini AR, Budday S, Karow M, Falk S.   +11 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

CASPR2 Autoimmune Antibodies Induce Neuronal Hyperactivity in Human Brain Organoids. [PDF]

J Neurochem
Oliveira AR, Cammarata G, Seabra C, Cardoso AM, Santos HJ, Guedes J, Sequeira D, Santos JMM, Oliveira G, Cardoso AL, Fernandes D, Leite MI, Coutinho E, Carvalho AL, Ferreira L, Peça J.   +15 more
europepmc   +1 more source

Predominance of In‐Field Recurrence After Radiotherapy for Sinonasal Cancer: A Single‐Center Retrospective Study

Head &Neck, EarlyView.
ABSTRACT Background Sinonasal malignancies (SNM) are rare, heterogeneous tumors with poor prognosis. There is an unmet need to improve treatment outcomes. Despite advances in imaging and molecular classification, optimal curative radiotherapy (RT) strategies remain undefined.
M. de Ridder, L. J. van de Velde, T. de Bie, R. van Noortwijk, C. P. J. Raaijmakers, E. H. Voormolen, W. W. Braunius, R. de Bree, G. E. Breimer, L. A. Devriese, E. J. Smid, J. A. Rijken   +11 more
wiley   +1 more source

Preconfigured neuronal firing sequences in human brain organoids. [PDF]

Nat Neurosci
van der Molen T, Spaeth A, Chini M, Hernandez S, Kaurala GA, Schweiger HE, Duncan C, McKenna S, Geng J, Lim M, Bartram J, Gänswein T, Dendukuri A, Zhang Z, Gonzalez-Ferrer J, Bhaskaran-Nair K, Morson AL, Harder CRK, Petzold LR, Alam El Din DM, Laird J, Schenke M, Smirnova L, Colquitt BM, Mostajo-Radji MA, Hansma PK, Teodorescu M, Hierlemann A, Hengen KB, Hanganu-Opatz IL, Kosik KS, Sharf T.   +31 more
europepmc   +1 more source