Results 191 to 200 of about 2,545,594 (299)

Establishing Area-Specific Brain Organoids Through Transcription Factor-Mediated Patterning. [PDF]

Biology (Basel)
Kim J, Jang YS, Lee M, Choi NY, Jung Y, Lim J, Kwak TH.   +6 more
europepmc   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Comparative Evaluation of hiPSC-Derived Brain Organoids as Platforms for Assessing Thyroid Hormone System Disrupting Chemicals. [PDF]

Cells
Fernandez Vallone V, Hellwig L, Rijntjes E, von Kügelgen N, Sane R, Opitz R, Kühnen P, Köhrle J, Mergenthaler P, Stachelscheid H.   +9 more
europepmc   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Ethical concerns about embodied brain organoids shaped by foundational distinctions and perceptions of consciousness. [PDF]

Sci Rep
Boyd JL, Jensen EA, Jensen AM, Lipshitz N.   +3 more
europepmc   +1 more source

Elucidating the Pro‐Tumor Role of LncRNA CROCCP2 in Glioma via the miR‐5584‐5p/HOXD11/Autophagy Pathway

Cancer Science, EarlyView.
The lncRNA CROCCP2 upregulates HOXD11 by competitively adsorbing miR‐5584‐5p, thereby promoting glioma cell proliferation, migration, and invasion by inhibiting autophagy. It significantly enhances tumor growth in vivo, suggesting it may be a potential therapeutic target for gliomas.
Feng Wang, Ganni Lei, Yuan Peng, Maoqiao Liu, Tianqi Jiang, Minghui Wang, Zhe Wang, Jun Pu, Jia Liu   +8 more
wiley   +1 more source

Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids. [PDF]

Nat Commun
Menacho C, Okawa S, Álvarez-Merz I, Wittich A, Muñoz-Oreja M, Lisowski P, Martín ML, Pentimalli TM, Zakin S, Thevandavakkam M, Jerred C, Lickfett S, Petersilie L, Rybak-Wolf A, Seibt A, Herebian D, Inak G, Brodesser S, Zaliani A, Mlody B, Donnelly J, Woleben K, Soriano FX, Fernandez-Checa JC, Ventura N, Cambridge S, Mayatepek E, Spinazzola A, Schuelke M, Rajewsky N, Rossi A, Peralvarez-Marin A, Distelmaier F, Perlstein E, Holt IJ, Puighermanal E, Pless O, Rose CR, Del Sol A, Prigione A.   +39 more
europepmc   +1 more source

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

Cell Proliferation, EarlyView.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu   +10 more
wiley   +1 more source

CASPR2 Autoimmune Antibodies Induce Neuronal Hyperactivity in Human Brain Organoids. [PDF]

J Neurochem
Oliveira AR, Cammarata G, Seabra C, Cardoso AM, Santos HJ, Guedes J, Sequeira D, Santos JMM, Oliveira G, Cardoso AL, Fernandes D, Leite MI, Coutinho E, Carvalho AL, Ferreira L, Peça J.   +15 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source