Results 191 to 200 of about 27,210 (261)

A human iPSC-based perfusable and membrane-free neurovascular unit-on-chip connecting brain organoids to the blood-brain barrier.

Lab Chip
Nogueira Pinto H, Kistemaker L, Ponomarenko M, Ermakov AA, Karsten-van Diepen M, van der Pol SMA, Pasterkamp RJ, Beekhuis-Hoekstra SD, de Wit NM, van Bodegraven EJ, de Vries HE, Hol EM.   +11 more
europepmc   +1 more source

Views on the distribution of consciousness influence ethical judgements toward brain organoids as biological computers: an exploratory study. [PDF]

Neurosci Conscious
Boyd JL, Jensen EA, Jensen AM, Lipshitz N.   +3 more
europepmc   +1 more source

The Gut–Brain Axis in Parkinson's Disease: From Clinical Observation toward Mechanism‐Based Precision Medicine

Movement Disorders, EarlyView.
Abstract Gastrointestinal dysfunction is increasingly recognized as a core feature of Parkinson's disease (PD), affecting quality of life, nutrition, medication response, and potentially the earliest stages of pathogenesis. This perspective traces the evolution of the gut from a neglected source of non‐motor symptoms to a central component of ...
Filip Scheperjans, Per Borghammer, Ronald F. Pfeiffer, Silke Appel‐Cresswell, Ali Keshavarzian   +4 more
wiley   +1 more source

Stretchable Microelectrode Arrays with Microneedles for Reliable Electrophysiological Recording of Human Heart and Brain Organoids. [PDF]

Adv Sci (Weinh)
Jang E, Shin S, Lee SG, Kim K, Kim Y, Sun J, Cho IJ, Gogos JA, Park JC, Kim CY, Lee HJ.   +10 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

BrAIn: A comprehensive artificial intelligence-based morphology analysis system for brain organoids and neuroscience. [PDF]

Bioeng Transl Med
Kahveci B, Polatli E, Evranos AE, Güner H, Karakülah G, Bastanlar Y, Güven S.   +6 more
europepmc   +1 more source

Patient iPSC‐derived astrocytes reveal impaired homeostasis and reactive‐like features in propionic acidemia

The Journal of Pathology, EarlyView.
Abstract Propionic acidemia (PA) is a neurometabolic disorder caused by propionyl‐CoA carboxylase deficiency with frequent neurological involvement, yet cell‐type‐specific mechanisms remain poorly defined. We established human induced pluripotent stem cell (iPSC)‐derived astrocytes (iAs) from patients harboring PCCA or PCCB mutations and investigated ...
Irene González‐Garnacho, Mar Álvarez, Francisco Zafra, Pilar Rodríguez‐Pombo, Lourdes R Desviat, Eva Richard   +5 more
wiley   +1 more source

Towards learning and memory risk assessment with human brain organoids: barriers and opportunities. [PDF]

Front Toxicol
Mohapatra R, Alam El Din DM, Zhao H, Hartung T, Smirnova L.   +4 more
europepmc   +1 more source

Expert consensus on clinical trial design guidelines for FLASH radiotherapy

Precision Radiation Oncology, EarlyView.
• FLASH radiotherapy has emerged as a transformative technology due to the underlying FLASH effect. • As FLASH radiotherapy moves toward clinical application, establishing standardized trial design principles is critical. • This expert consensus provides a roadmap for rigorous clinical evaluation of FLASH radiotherapy, accelerating safe translation of ...
Hui Luo, Chen Cheng, Chengliang Yang, Bing Li, Jiandong Zhang, Jinbo Yue, Zhaoyang Lou, Hui Liu, Jing Cai, Hong Ge   +9 more
wiley   +1 more source

Establishing Area-Specific Brain Organoids Through Transcription Factor-Mediated Patterning. [PDF]

Biology (Basel)
Kim J, Jang YS, Lee M, Choi NY, Jung Y, Lim J, Kwak TH.   +6 more
europepmc   +1 more source