Results 211 to 220 of about 27,210 (261)

Mechanical impact on neural stem cell lineage decisions in human brain organoids. [PDF]

EMBO Rep
Lampersperger H, Tranchina M, Meth B, Han D, Nayebzadeh N, Reiter N, Kuth S, Lorke M, Boccaccini AR, Budday S, Karow M, Falk S.   +11 more
europepmc   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids. [PDF]

Nat Commun
Menacho C, Okawa S, Álvarez-Merz I, Wittich A, Muñoz-Oreja M, Lisowski P, Martín ML, Pentimalli TM, Zakin S, Thevandavakkam M, Jerred C, Lickfett S, Petersilie L, Rybak-Wolf A, Seibt A, Herebian D, Inak G, Brodesser S, Zaliani A, Mlody B, Donnelly J, Woleben K, Soriano FX, Fernandez-Checa JC, Ventura N, Cambridge S, Mayatepek E, Spinazzola A, Schuelke M, Rajewsky N, Rossi A, Peralvarez-Marin A, Distelmaier F, Perlstein E, Holt IJ, Puighermanal E, Pless O, Rose CR, Del Sol A, Prigione A.   +39 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Vascularized human brain organoids as a model of the brain-peripheral axis in HIV-1 neuropathogenesis. [PDF]

Sci Rep
Selvam S, Dos Reis RS, Wagner MCE, Krishnakumar R, Keshavarz K, Ebrahimkhani MR, Ayyavoo V.   +6 more
europepmc   +1 more source

From Transplantology to Organ Medicine: When the Organ Becomes an Independent Platform

Organ Medicine, EarlyView.
Qiang Zhang, Zhiyong Guo, Xiaomin Shi, Guodong Chen, Xiaoshun He   +4 more
wiley   +1 more source

Intermittent Propofol Exposure Induces Neurodevelopmental Alterations in Human Brain Organoids. [PDF]

Cell Mol Neurobiol
Wang S, Hall C, Wang Y, Link L, Zhang Y, Schlägel A, Wunder C, Patzke C, Klein M, Mittmann T, Schäfer MKE.   +10 more
europepmc   +1 more source

Brain organoids as precision models for neurodegenerative diseases: from disease modeling to drug discovery. [PDF]

Front Neurosci
Zheng Y, Zhou W, Chang H, Zheng K.
europepmc   +1 more source

Female metabolic resilience and male-biased protein quality defects under hypoxia in human brain organoids. [PDF]

iScience
Gaston-Breton R, Bouzid A, Antipushina E, Costa N, Sarkadi B, Apati A, Harati R, Sharaev M, Armengaud J, Disdier C, Hamoudi R, Mabondzo A.   +11 more
europepmc   +1 more source