Results 21 to 30 of about 1,057,184 (299)

SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

Nature Communications, 2020
Cancer stem cells can evade treatment. Here, the authors perform an in vitro screen to identify proteins that are involved in protecting glioma cancer stem cells from therapy and find that SPT6 increases BRCA1 expression and drives error-free DNA repair,
Elisabeth Anne Adanma Obara, Diana Aguilar-Morante, Rikke Darling Rasmussen, Alex Frias, Kristoffer Vitting-Serup, Yi Chieh Lim, Kirstine Juul Elbæk, Henriette Pedersen, Lina Vardouli, Kamilla Ellermann Jensen, Jane Skjoth-Rasmussen, Jannick Brennum, Lucie Tuckova, Robert Strauss, Christoffel Dinant, Jiri Bartek, Petra Hamerlik   +16 more
doaj   +1 more source

IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in Glioblastoma multiforme cells

Cell Division, 2020
Background Recurrence of Glioblastoma multiforme (GBM) seems to be the rule despite combination therapies. Cell invasion and cell proliferation are major reasons for recurrence of GBM. And insulin-like growth factor binding protein 5 (IGFBP5) is the most
Chengyuan Dong, Junwen Zhang, Sheng Fang, Fusheng Liu   +3 more
doaj   +1 more source

Combination of Immunotherapy and Radiotherapy for Recurrent Malignant Gliomas: Results From a Prospective Study

Frontiers in Immunology, 2021
BackgroundWorld Health Organization (WHO) grade IV glioma remains one of the most lethal tumors with a dismal prognosis and inevitable recurrence. We evaluated the safety and efficacy of immunotherapy with radiotherapy in this population of patients ...
Haihui Jiang, Haihui Jiang, Kefu Yu, Yong Cui, Yong Cui, Xiaohui Ren, Xiaohui Ren, Mingxiao Li, Mingxiao Li, Chuanwei Yang, Chuanwei Yang, Xuzhe Zhao, Xuzhe Zhao, Qinghui Zhu, Qinghui Zhu, Song Lin, Song Lin, Song Lin   +17 more
doaj   +1 more source

Aquaporin-4 and brain edema. [PDF]

, 2007
Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood.
A Lehmenkuhler, Alan S. Verkman, AS Verkman, AS Verkman, D Wenzel, DK Binder, DK Binder, DK Binder, DS Prough, GT Manley, H Wen, HJ Reulen, HK Kimelberg, I Klatzo, I Roberts, J Badaut, J Hu, J Li, J Li, JE Rash, JE Rash, K Oshio, KI Auguste, M Amiry-Moghaddam, M Amiry-Moghaddam, M Elkjaer, Marios C. Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, NR Saunders, O Bloch, P Agre, P Padmawar, PM Rodier, S Nielsen, S Saadoun, S Saadoun, T Ma   +38 more
core   +2 more sources

Brain Tumors [PDF]

Acta Oncologica, 1996
This synthesis of the literature on radiotherapy for brain tumors, ie, cancer originating in the central nervous system (CNS), is based on 81 scientific articles, including 25 randomized studies, 13 prospective studies, and 25 retrospective studies. These studies involve 11,081 patients.
openaire   +2 more sources

Focused ultrasound-enabled brain tumor liquid biopsy [PDF]

, 2018
Although blood-based liquid biopsies have emerged as a promising non-invasive method to detect biomarkers in various cancers, limited progress has been made for brain tumors.
Chen, Hong, Cheng, Galen, Dunn, Gavin P., Leuthardt, Eric C., Liu, Weijun, Nazeri, Arash, Petti, Allegra A., Wang, Xiaowei, Ye, Dezhuang, Yue, Yimei, Zhu, Lifei   +10 more
core   +3 more sources

The Visual Acuity Outcome and Relevant Factors Affecting Visual Improvement in Pediatric Sporadic Chiasmatic–Hypothalamic Glioma Patients Who Received Surgery

Frontiers in Neurology, 2020
Background: The role and effectiveness of primary surgical treatment for sporadic chiasmatic–hypothalamic glioma (CHG) are not clear. The present study was to describe sporadic CHG visual acuity (VA) outcomes after surgery and to analyze the relevant ...
Chihyi Liao, Chihyi Liao, Heng Zhang, Heng Zhang, Zhiming Liu, Zhiming Liu, Zhe Han, Zhe Han, Chunde Li, Chunde Li, Jian Gong, Jian Gong, Wei Liu, Wei Liu, Zhenyu Ma, Zhenyu Ma, Yongji Tian, Yongji Tian   +17 more
doaj   +1 more source

Myelopoiesis during Solid Cancers and Strategies for Immunotherapy

Cells, 2021
Our understanding of the relationship between the immune system and cancers has undergone significant discovery recently. Immunotherapy with T cell therapies and checkpoint blockade has meaningfully changed the oncology landscape.
Tyler J. Wildes, Bayli DiVita Dean, Catherine T. Flores   +2 more
doaj   +1 more source

RFDCR:Automated brain lesion segmentation using cascaded random forests with dense conditional random fields [PDF]

, 2020
Segmentation of brain lesions from magnetic resonance images (MRI) is an important step for disease diagnosis, surgical planning, radiotherapy and chemotherapy.
Chen, Gaoxiang, Li, Qun, Pan, Zhifang, Rekik, Islem, Shi, Fuqian, Wang, Li   +5 more
core   +2 more sources

Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells

Biomedicines, 2022
Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs ...
Simranjit X. Singh, Rui Yang, Kristen Roso, Landon J. Hansen, Changzheng Du, Lee H. Chen, Paula K. Greer, Christopher J. Pirozzi, Yiping He   +8 more
doaj   +1 more source