Results 31 to 40 of about 1,057,184 (299)
Brain tumors induced in rats by human adenovirus type 12 [PDF]
, 1974 Oncogenesis of human adenovirus type 12 in the brain of rats was examined. Newborn rats of Sprague-Dawley and Donryu strains were injected intracranially with human adenovirus type 12. The incidence of intracranial tumors was 91% (30/33) in
Matsuo, Keisuke +5 more
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Lin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade
Nature Communications, 2018 Brain tumors are difficult to treat using existing immunotherapeutic strategies. Here, the authors show that in brain tumors resistant to PD-1 blockade, HSCs expressing CCR2+ can reverse treatment resistance and sensitizes mice to immunotherapy.
Catherine T. Flores +6 more
doaj +1 more source
Clinical evaluation of a dedicated next generation sequencing panel for routine glioma diagnostics
Acta Neuropathologica Communications, 2018 Since 2013 next-generation sequencing (NGS) targeting genes mutated in diffuse gliomas is part of routine diagnostics in our institute. In the present report, we evaluate the use of this custom tailored NGS platform on 434 samples. The NGS panel assesses
Nathalie E. Synhaeve +8 more
doaj +1 more source
Seminars in Surgical Oncology, 1999 Pediatric brain tumors differ from adult brain tumors in several major ways. First, the types of tumors encountered in children are uncommon in adults, and vice versa. Second, tumors of the posterior fossa comprise a far greater percentage of tumors in children as compared to adults. Third, the value of extensive tumor resection, which is controversial
J, Siffert +3 more
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Malignant Progression Contributes to the Failure of Combination Therapy for Atypical Meningiomas
Frontiers in Oncology, 2021 ObjectiveTo investigate the independent risk factors for recurrence in intracranial atypical meningiomas (AMs) treated with gross total resection (GTR) and early external beam radiotherapy (EBRT).MethodsClinical, radiological, and pathological data of ...
Qing Zhang +40 more
doaj +1 more source
Integrated genomic analyses of de novo pathways underlying atypical meningiomas
Nature Communications, 2017 Meningiomas are mostly benign brain tumours with the potential for becoming atypical or malignant. Here, the authors show that primary atypical meningiomas are epigenetically and genetically distinct from benign and progressed tumours, highlighting ...
Akdes Serin Harmancı +26 more
doaj +1 more source
Anatomical landmark based registration of contrast enhanced T1-weighted MR images [PDF]
, 2010 In many problems involving multiple image analysis, an im- age registration step is required. One such problem appears in brain tumor imaging, where baseline and follow-up image volumes from a tu- mor patient are often to-be compared.
Demir, Ali +3 more
core +1 more source
Modeling brain dynamics in brain tumor patients using the virtual brain [PDF]
, 2018 Presurgical planning for brain tumor resection aims at delineating eloquent tissue in the vicinity of the lesion to spare during surgery. To this end, noninvasive neuroimaging techniques such as functional MRI and diffusion-weighted imaging fiber ...
Achten, Eric +6 more
core +1 more source
Frontiers in Oncology, 2020 BackgroundThis study was designed to explore the progression patterns of IDH-wildtype glioblastoma (GBM) at first recurrence after chemoradiotherapy.MethodsRecords from 247 patients who underwent progression after diagnosis of IDH-wildtype GBM was ...
Haihui Jiang +14 more
doaj +1 more source
First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma. [PDF]
, 2020 PurposeGDC-0084 is an oral, brain-penetrant small-molecule inhibitor of PI3K and mTOR. A first-in-human, phase I study was conducted in patients with recurrent high-grade glioma.Patients and methodsGDC-0084 was administered orally, once daily, to ...
Cloughesy, Timothy F +11 more
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