Results 271 to 280 of about 780,926 (363)
Estimating Toxicity Putative Mechanisms from Smoking Residual Substances Using a Whole-Cell Bioreporter System. [PDF]
Bar T +5 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Laser-printed document classification using random forest and gray prediction models. [PDF]
Qu Y, Yu C, Li C, Yang Y.
europepmc +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Transparent Packaging for Tea: Exploring the Role of Trust in Emerging Markets for Tea Beverages. [PDF]
Yu Y +6 more
europepmc +1 more source
Storytelling as a Branding Tool for Food Tourism: A Toolkit for Entrepreneurs in Lahti Region [PDF]
Koiloth, Keerthana Sai
openalex
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Tobacco industry pricing strategies during recent tax adjustments in Mexico: evidence from sales data. [PDF]
Saenz-de-Miera B +4 more
europepmc +1 more source

