Clinical outcomes and prognostic features of germline BRCA mutant breast cancer patients: single-center experience, Madinah, Saudi Arabia [PDF]
World Cancer Research JournalObjective: The aim of this study is to evaluate the clinicopathological features and prognostic impact of breast cancer harboring germline BRCA1/2 mutation.
M. Aljahel +16 more
doaj +1 more source
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in Cypriot population. [PDF]
, 2010 Inability to correctly repair DNA damage is known to play a role in the development of breast cancer. Single nucleotide polymorphisms (SNPs) of DNA repair genes have been identified, which modify the DNA repair capacity, which in turn may affect the risk
Bashiardes, E +9 more
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Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX [PDF]
, 2018 Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with lack of predictive biomarkers. We conducted a study to assess DNA damage repair (DDR) gene mutations as a predictive biomarker in PDAC patients treated with FOLFIRINOX ...
Gbolahan, Olumide +8 more
core +1 more source
The World Journal of Men's HealthProstate cancer (PC) treatment has reached a milestone with the introduction of poly(ADP-ribose) polymerase (PARP) inhibitors. PARP inhibitors (PARPi) induce breaks in single-stranded and/or double-stranded DNA, resulting in synthetic lethality in ...
Whi-An Kwon
doaj +1 more source
Nationwide Study of Breast Cancer Risk Factors in Latinas [PDF]
, 2011 Breast cancer is the most common cancer among American women. Any woman can be affected by breast cancer, with risk for the disease increasing with age. Risk for breast cancer is also exacerbated in women who have certain genetic alterations.
Julie Sawitzke +3 more
core +3 more sources
Defective DNA repair mechanisms in prostate cancer: impact of olaparib [PDF]
, 2017 The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects.
De Felice, Francesca +4 more
core +2 more sources
?????? ??????????????: ???????????????? ?????????????? ?????????????? ???? ???????????????? ???????????????? ???????????????????? ?????????????? ?? ?????????? BRCA1 ???? BRCA2 [PDF]
, 2019 ?? ???????????? ???????????????????????????? ???????? ???????????????????? ?? ???????????????????? ?????????????? ???????????????????? ???????????????? ???????? ?????????????? (????) ???? ??????????????, ???? ?????????????????????? ?? ?????????????????? ?? ??????????-???????????????????? ???????????????????? ?????????? BRCA1/2, ?? ???? ?????????????????
openaire +3 more sources
BRCA1 alternative splicing in breast tumorogenesis [PDF]
Introduction: Alternative splicing helps transcription process to produce many proteins from single gene and has important roles on tumorogenesis. The BRCA1 gene has almost 11 alternate spliced variants which have been mentioned as susceptibility ...
اخوان, هما +6 more
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