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Primary and metastatic brain tumours in hereditary cancer syndromes: case reports with and literature review. [PDF]
Hered Cancer Clin PractRobaczyńska J +10 more
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Meeting abstracts from the Annual Conference "Clinical Genetics of Cancer 2024". [PDF]
Hered Cancer Clin Practeuropepmc +1 more source
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Mutation Research/Reviews in Mutation Research, 2002
Breast cancer is one of the most frequent malignancies affecting women. The human breast cancer gene 1 (BRCA1) gene is mutated in a distinct proportion of hereditary breast and ovarian cancers. Tumourigenesis in individuals with germline BRCA1 mutations requires somatic inactivation of the remaining wild-type allelle. Although, this evidence supports a
Marion, Kubista +7 more
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Breast cancer is one of the most frequent malignancies affecting women. The human breast cancer gene 1 (BRCA1) gene is mutated in a distinct proportion of hereditary breast and ovarian cancers. Tumourigenesis in individuals with germline BRCA1 mutations requires somatic inactivation of the remaining wild-type allelle. Although, this evidence supports a
Marion, Kubista +7 more
openaire +2 more sources
Breast Disease, 1998
In a very real sense, the search for a breast cancer susceptibility gene reflects the rapid evolution of molecular genetics as a field and the power of molecular technology to accelerate the pace of discovery. This search began with the study of blood proteins through biochemical analysis; the number of loci accessible was limited, and very few ...
B, Newman, E T, Liu
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In a very real sense, the search for a breast cancer susceptibility gene reflects the rapid evolution of molecular genetics as a field and the power of molecular technology to accelerate the pace of discovery. This search began with the study of blood proteins through biochemical analysis; the number of loci accessible was limited, and very few ...
B, Newman, E T, Liu
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Identification of BRCA1-IRIS, a BRCA1 locus product
Nature Cell Biology, 2004Breast cancer is the most common malignancy among women, and mutations in the BRCA genes produce increased susceptibility to these malignancies in certain families. Here we identify BRCA1-IRIS as a 1,399-amino-acid BRCA1 gene product encoded by an uninterrupted open reading frame that extends from codon 1 of the known BRCA1 open reading frame to a ...
Wael M, ElShamy, David M, Livingston
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2018
?????????????? ?????????????????? ???????????????? ?? ?????????????????? ?? ???????????????? ???????????????? ?????????? BRCA1. BRCA1 ???????????? ???????????? ???????? ?? ?????????????????????????????? ?????????????????? ?????????????????????????????????? ???????????? (???????????????? ???????????????????? ??????????, ????????????????????????, ????????
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?????????????? ?????????????????? ???????????????? ?? ?????????????????? ?? ???????????????? ???????????????? ?????????? BRCA1. BRCA1 ???????????? ???????????? ???????? ?? ?????????????????????????????? ?????????????????? ?????????????????????????????????? ???????????? (???????????????? ???????????????????? ??????????, ????????????????????????, ????????
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Current Problems in Cancer, 2014
A hereditary breast cancer syndrome can present in a variety of ways ranging from an index case of early-onset breast cancer to an incidental finding during an endoscopy or a dermatological examination. A comprehensive review of the patient’s personal and family history is essential to accurately assess the risk for a hereditary cancer syndrome ...
Kimberly, King-Spohn, Robert, Pilarski
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A hereditary breast cancer syndrome can present in a variety of ways ranging from an index case of early-onset breast cancer to an incidental finding during an endoscopy or a dermatological examination. A comprehensive review of the patient’s personal and family history is essential to accurately assess the risk for a hereditary cancer syndrome ...
Kimberly, King-Spohn, Robert, Pilarski
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Cancer Investigation, 2001
The breast cancer susceptibility gene BRCA1 on chromosome 17q21 encodes an 1863 amino acid protein that is important for normal embryonic development. Germline mutations of this gene are linked to a significantly increased lifetime risk for breast and/or ovarian cancer, and recent studies suggest that the same may be true for prostate cancer.
E M, Rosen, S, Fan, I D, Goldberg
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The breast cancer susceptibility gene BRCA1 on chromosome 17q21 encodes an 1863 amino acid protein that is important for normal embryonic development. Germline mutations of this gene are linked to a significantly increased lifetime risk for breast and/or ovarian cancer, and recent studies suggest that the same may be true for prostate cancer.
E M, Rosen, S, Fan, I D, Goldberg
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Transcriptional regulation of BRCA1
1999Abstract : Germline mutations in BRCAl lead to an increased risk of breast and ovarian cancer, with loss of the second, normal allele critical to tumorigenesis. It was widely presumed that the cloning and characterization of genes involved in hereditary breast cancer would lead to a better understanding of the genesis of the more common non-inherited ...
Mary C. King, Shannon R. Payne
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