Results 191 to 200 of about 68,288 (264)
Welcome Pathogens: Transient Heat Dampens Immune Responses to Acibenzolar‐S‐Methyl in Apple Plants
Plant, Cell &Environment, Volume 49, Issue 3, Page 1229-1248, March 2026.ABSTRACT
Climate change affects plant‐pathogen interactions, with disease outcome varying depending on the pathosystem and environmental scenario. In Arabidopsis, a thermo‐sensitive module of salicylic acid (SA) signalling makes immunity vulnerable to heat.Erwan Chavonet, Bao‐huynh Nguyen, Christelle Heintz, Raphaël Cournol, Jitka Široká, Ondřej Novák, Romain Larbat, Matthieu Gaucher, Marie‐Noëlle Brisset, Florent Pantin, Alexandre Degrave +10 morewiley +1 more sourceSequential platinum and PARP Inhibition enhances PD1 immunotherapy efficacy in murine Brca2 mutated pancreatic cancer. [PDF]
Sci RepMcVey JC, Wattenberg MM, Coho H, Infante K, Markowitz K, Delman D, Clendenin C, Furth EE, Tondon R, Stanger BZ, Vonderheide RH, Reiss KA, Beatty GL. +12 moreeuropepmc +1 more sourceAumolertinib with carboplatin–pemetrexed versus aumolertinib for nonsmall cell lung cancer with EGFR and concomitant tumor suppressor genes (ACROSS2): An open‐label, multicenter, randomized phase 3 study
CA: A Cancer Journal for Clinicians, Volume 76, Issue 2, March/April 2026.ABSTRACT
Third‐generation epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) are standard first‐line therapy for advanced, EGFR‐mutated nonsmall cell lung cancer (NSCLC). However, their benefit is limited in patients who have co‐existing tumor suppressor gene (TSG) mutations, highlighting a need for intensified strategies to ...Jian‐Chun Duan, Jia Zhong, Bo‐Yang Sun, Wen‐Hua Zhao, Lin Wu, Kai‐Lun Fei, Qian Chu, Qi‐Sen Guo, Qi‐Bin Song, Yan Yu, Da‐Xing Zhu, Xin‐Yan Liu, Jun Zhao, Zhi‐Xiang Zhan, Shi Li, Lei Nie, Jie Lin, Xiao‐Dong Peng, Dian‐Sheng Zhong, Jin Zhou, Li‐Hua Li, Yun‐Fang Chen, Chen Hu, Tony Mok, Zhi‐Jie Wang, Jie Wang +25 morewiley +1 more sourceEthical considerations of genetic and genomic testing in pediatric oncology: A narrative review
CA: A Cancer Journal for Clinicians, Volume 76, Issue 2, March/April 2026.Abstract
Genomics—and genomic testing in particular—has transformed oncology, facilitating both targeted therapies and personalized care. In pediatric oncology, unique clinical and ethical considerations arise. Compared with adults, children and adolescents are affected by more limited evidence regarding test performance, variant interpretation, and ...Brittany L. Greene, Jonathan M. Marronwiley +1 more sourceMutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations
Human Mutation, 2018 T. Rebbeck, T. Friebel, E. Friedman, U. Hamann, D. Huo, A. Kwong, E. Oláh, O. Olopade, A. Solano, S. Teo, M. Thomassen, J. Weitzel, T. Chan, F. Couch, D. Goldgar, T. Kruse, E. Palmero, Sue-Kyung Park, Diana Torres, E. J. Rensburg, L. McGuffog, M. Parsons, Goska Leslie, C. Aalfs, J. Abugattas, J. Adlard, S. Agata, K. Aittomäki, L. Andrews, I. Andrulis, A. Arason, N. Arnold, B. Arun, E. Asseryanis, L. Auerbach, J. Azzollini, J. Balmaña, M. Barile, R. Barkardottir, Daniel Barrowdale, J. Benítez, A. Berger, R. Berger, Amie M. Blanco, K. Blazer, M. Blok, V. Bonadona, B. Bonanni, A. Bradbury, C. Brewer, B. Buecher, S. Buys, T. Caldés, A. Caliebe, M. Caligo, I. Campbell, S. Caputo, J. Chiquette, W. Chung, K. Claes, J. Collée, J. Cook, R. Davidson, Miguel de la Hoya, K. Leeneer, A. Pauw, Capucine Delnatte, O. Díez, Y. Ding, N. Ditsch, S. Domchek, C. M. Dorfling, C. Velázquez, B. Dworniczak, J. Eason, D. Easton, R. Eeles, H. Ehrencrona, B. Ejlertsen, C. Engel, S. Engert, D. Evans, L. Faivre, L. Feliubadaló, Sandra Fert Ferrer, L. Foretova, J. Fowler, D. Frost, H. Galvão, P. Ganz, J. Garber, M. Gauthier-Villars, A. Gehrig, A. Gerdes, P. Gesta, G. Giannini, S. Giraud, G. Glendon, A. Godwin, M. Greene, J. Gronwald, A. Gutierrez-Barrera, E. Hahnen, J. Hauke, A. Henderson, J. Hentschel, F. Hogervorst, E. Honisch, E. Imyanitov, C. Isaacs, L. Izatt, A. Izquierdo, A. Jakubowska, P. James, R. Janavicius, U. Jensen, E. John, J. Vijai, Katarzyna Kaczmarek, B. Karlan, K. Kast, kConFab investigators, Sung-Won Kim, I. Konstantopoulou, J. Korach, Y. Laitman, A. Lasa, C. Lasset, C. Lázaro, Annette Lee, Min-Hyuk Lee, J. Lester, F. Lesueur, A. Liljegren, N. Lindor, M. Longy, J. Loud, K. Lu, J. Lubiński, E. Macháčková, S. Manoukian, V. Mari, C. Martínez‐Bouzas, Z. Mátrai, Noura Mebirouk, H. Meijers-Heijboer, A. Meindl, A. Mensenkamp, U. Mickys, Austin Miller, M. Montagna, K. Moysich, A. Mulligan, Jacob Musinsky, S. Neuhausen, H. Nevanlinna, J. Ngeow, H. Nguyen, D. Niederacher, H. Nielsen, F. Nielsen, R. Nussbaum, K. Offit, Anna Öfverholm, K. Ong, A. Osorio, L. Papi, J. Papp, B. Pasini, I. Pedersen, Ana Peixoto, N. Peruga, P. Peterlongo, E. Pohl, Nisha Pradhan, Karolina Prajzendanc, F. Prieur, P. Pujol, P. Radice, S. Ramus, Johanna Rantala, M. Rashid, K. Rhiem, M. Robson, G. Rodriguez, M. Rogers, Vilius Rudaitis, A. Schmidt, R. Schmutzler, L. Senter, P. Shah, Priyanka Sharma, L. Side, J. Simard, C. Singer, A. Skytte, T. Slavin, K. Snape, H. Sobol, M. Southey, L. Steele, D. Steinemann, G. Sukiennicki, C. Sutter, C. Szabo, Y. Tan, M. Teixeira, M. Terry, A. Teule, Abigail S. Thomas, D. Thull, M. Tischkowitz, S. Tognazzo, A. Toland, S. Topka, A. Trainer, N. Tung, C. Asperen, Annemieke H. der Hout, L. E. D. der Kolk, Rob B. der Luijt, M. Heetvelde, L. Varesco, R. Varon‐Mateeva, A. Vega, C. Villarreal-Garza, A. Wachenfeldt, L. Walker, S. Wang-gohrke, B. Wappenschmidt, B. Weber, D. Yannoukakos, S. Yoon, C. Zanzottera, J. Zidan, K. Zorn, Christina G Hutten Selkirk, P. Hulick, G. Chenevix-Trench, A. Spurdle, A. Antoniou, K. Nathanson +241 moresemanticscholar +1 more sourceEvaluation of quantitative polymerase chain reaction for detecting BRCA1 or BRCA2 copy number loss in high-grade serous ovarian cancer. [PDF]
Sci RepOswald AJ, Hollis RL, Churchman M, Croy I, Ewing A, Thomson JP, Stillie LJ, Merry E, Albertella M, Forment JV, Roxburgh P, Semple CA, Herrington CS, Gourley C. +13 moreeuropepmc +1 more source
