Results 181 to 190 of about 66,967 (213)

Highlight: BRCA1 and BRCA2 proteins in breast cancer

Microscopy Research and Technique, 2002
AbstractHeterozygous carriers of loss‐of‐function germline mutations in the BRCA1 or BRCA2 breast cancer susceptibility genes have a predisposition to breast and ovarian cancer. Multiple functions have been ascribed to the products of these genes, linking them to pathways that inhibit progression to neoplasia.
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Biological Functions of the BRCA1 and BRCA2 Proteins

1999
Breast cancer is the most commonly diagnosed nondermatologic cancer in women in the United States. It is second only to lung cancer as the most frequent cause of cancer-related deaths in American women. In 1996, the American Cancer Society projected over 184,000 newly diagnosed cases of breast cancer and over 44,000 deaths secondary to invasive breast ...
Helen K. Chew, Andrew A. Farmer, Wen-Hwa Lee   +2 more
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Functional Characterization of BRCA1 and BRCA2: Clues from Their Interacting Proteins

Journal of Mammary Gland Biology and Neoplasia, 1998
The familial breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2 have been the subject of extensive functional analysis studies since their cloning. Clues to their biological role in maintaining the genomic integrity were provided by studies that revealed their interaction with the recombination repair protein HsRad51.
S K, Sharan, A, Bradley
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A Novel BRCA2-Binding Protein and Breast and Ovarian Tumorigenesis

New England Journal of Medicine, 2004
A fundamental question of cancer genetics is how genes responsible for inherited cancer contribute to the far more frequent cases of cancer that are purely somatic in origin.
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Impact of Disrupted Brca2 Protein-Protein Interactions on DNA Repair and Tumorigenesis

2001
Abstract : In this report, we have analyzed the protein encoded by the murine Brca2 locus. We find that murine Brca2 shares multiple properties with human BRCA2 including its regulation during the cell cycle, localization to nuclear foci, and interaction with Brca1 and Rad51.
Lewis A. Chodosh, Christopher J. Sarkisian   +1 more
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Biochemical Analysis of the BRCA2 Protein Complex

2004
Abstract : This linked career development award and idea award (CDA part) aims at relieving my administrative duties to acquire molecular biology skills in biology research. I have learned all the molecular biology techniques in accordance to Task 1 and 2 as stated in the Statement of Work.
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Brca1 and Brca2 protein expression patterns in different tissues of murine origin

International Journal of Oncology, 2001
We have analyzed by immunohistochemistry Brca1 and Brca2 protein expression in mouse during embryonic development, in adult tissues, and during postnatal mammary gland development. Our observations confirm previous localization of Brca1 and Brca2 mRNA on frozen sections by in situ hybridization, and demonstrate that Brca1 and Brca2 proteins are ...
D J, Bernard-Gallon, M P, De Latour, V, Sylvain, C, Vissac, B, Aunoble, J, Chassagne, Y J, Bignon   +6 more
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Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2

DNA Repair, 2006
Fanconi anaemia is an inherited chromosomal instability disorder characterised by cellular sensitivity to DNA interstrand crosslinkers, bone-marrow failure and a high risk of cancer. Eleven FA genes have been identified, one of which, FANCD1, is the breast cancer susceptibility gene BRCA2. At least eight FA proteins form a nuclear core complex required
Hussain, S, Wilson, J B, Blom, E, Thompson, L H, Sung, P, Gordon, S M, Kupfer, G M, Joenje, H, Mathew, C G, Jones, N J   +9 more
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The Brca1 and Brca2 proteins and tumor pathogenesis.

Anticancer research, 2000
Germline alterations of the BRCA1 or BRCA2 genes result in susceptibility to breast and ovarian cancer. Protein-protein interaction studies, transcription activity and mouse knockout experiments have suggested that the Brca1 and Brca2 proteins are of importance in DNA repair and maintenance of genome integrity, possibly due to the transactivation ...
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Internal repeats in the BRCA2 protein sequence

Nature Genetics, 1996
Peer Bork, Niklas Blomberg, Michael Nilges   +2 more
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