Results 81 to 90 of about 131,173 (232)

Genetic Control of Canalization for Twinning Rates in Polypay and Rambouillet Sheep Using Threshold or Double Hierarchical Generalized Linear Models

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT In most sheep production systems, the ideal scenario is for every ewe to lamb and successfully raise twins. However, selection for increased number of lambs born (NLB) is often accompanied by a higher incidence of triplet and higher‐order births, which increases management challenges and producer reluctance to intensify selection for this ...
Carrie S. Wilson, J. Bret Taylor, Luiz F. Brito   +2 more
wiley   +1 more source

Luciferase-LOV BRET enables versatile and specific transcriptional readout of cellular protein-protein interactions

bioRxiv, 2019
Technologies that convert transient protein-protein interactions (PPIs) into stable expression of a reporter gene are useful for genetic selections, high-throughput screening, and multiplexing with omics technologies. We previously reported SPARK (Kim et
Christina K. Kim, K. Cho, Min Woo Kim, A. Ting   +3 more
semanticscholar   +1 more source

Le Bret (Cardin)

Correspondance de Richelieu, 2022
Article rédigé et publié par Marie-Catherine Vignal Souleyreau, soumis à droits d'auteur Cardin Le Bret (v. 1558-1655), seigneur de Flacourt, Millaubourt, Fonrieux, etc., est le fils de Julien Le Bret, avocat établi à Gisors, et de Marguerite Viel. D’abord avocat général à la cour des aides de Paris entre 1590 et 1604, il devient à cette date avocat ...
openaire   +2 more sources

Posthumanism and Cybernetic Art: An Esthetic Exploration of Technology and Human Identity

Sociology Lens, EarlyView.
ABSTRACT Posthumanism is a contemporary intellectual movement that redefines the relationship between humans, technology, biology, and culture. While questioning the traditional humanist perspective that places humans at the center of the universe, it also examines the transformative effects of technology on human identity.
Evren Kavukcu
wiley   +1 more source

Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET

Nature Communications, 2016
Endocytosis and intracellular trafficking of receptors are pivotal to maintain physiological functions and drug action; however, robust quantitative approaches are lacking to study such processes in live cells.
Y. Namkung, C. Le Gouill, V. Lukashova, Hiroyuki Kobayashi, M. Hogue, E. Khoury, Mideum Song, M. Bouvier, S. Laporte   +8 more
semanticscholar   +1 more source

Enhanced BRET technology for the monitoring of agonist-induced and agonist-independent interactions between GPCRs and β-arrestins

Frontiers in Endocrinology, 2011
The bioluminescence resonance energy transfer (BRET) technique has become extremely valuable for the real-time monitoring of protein-protein interactions in live cells.
Martina eKocan, Martina eKocan, Matthew eDalrymple, Ruth eSeeber, Brian eFeldman, Kevin ePfleger   +5 more
doaj   +1 more source

High Proportion of PNH Type II Neutrophils Is Associated With Thrombosis in Patients Displaying a PNH Clone ≥ 1%

American Journal of Hematology, Volume 101, Issue 9, Page 2311-2328, September 2026.
ABSTRACT The clinical significance of PNH Type II white blood cells (WBCs) remains unclear. We assessed the relative percentage (rel%) of Type II neutrophils in 355 patients with a PNH clone ≥ 1% on neutrophils enrolled by 33 flow cytometry laboratories in the 5‐year French nation‐wide multicenter prospective observational study.
Orianne Wagner‐Ballon, Anne‐Catherine Lhoumeau, Anna Raimbault, Camille Debord, Jean‐Philippe Vial, Valérie Soenen, Mélanie Pannetier, Edouard Bonneville, Elsa Bera, Caroline Bret, Nicolas Chapuis, Véronique Latger‐Cannard, Caroline Mayeur‐Rousse, Véronique Harrivel, François Vergez, Marie Loosveld, Juliette Vo Xuan, Stéphanie Mathis, Gérard Socié, Flore Sicre de Fontbrune, Régis Peffault de Latour, Bernard Drenou, Agathe Debliquis, Magali Le Garff‐Tavernier, on behalf of the French PNH working group CytHem‐HPN, Thomas Boyer, Mikaël Roussel, Marie Guillon, Sabrina Bouyer, Isabelle Kittler, Franck Geneviève, Julien Guy, Sophie Brun, Claude Capron, Sébastien Lachot, Francine Garnache‐Ottou, Richard Veyrat‐Masson, Corine Brunet, Caren Brumpt, Ludovic Lhermitte. Finally, Louis Terriou, Nicolas Blin   +41 more
wiley   +1 more source

Detection of the Vascular Endothelial Growth Factor with a Novel Bioluminescence Resonance Energy Transfer Pair Using a Two-Component System

Sensors, 2017
In this paper we describe a two-component BRET (bioluminescence resonance energy transfer)-based method to detect vascular endothelial growth factor (VEGF) molecules in unknown samples as the basis for subsequent in vivo use.
Tobias Wimmer, Eva Schroeter, Birgit Lorenz, Knut Stieger   +3 more
doaj   +1 more source

CCL19 and CCL21 Display Reciprocal Dependence on R209 in ECL2 of CCR7 for Receptor Activation, Relating to Differences in the Chemokine N‐Terminal Region

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT CCL19 and CCL21 interact differentially with their shared receptor CCR7. A key amino acid important for CCL19‐mediated receptor activation is arginine 209 (R209) in extracellular loop 2 (ECL2) of CCR7. CCL21 activation of CCR7, in contrast, does not depend on R209.
Mette Marie Rosenkilde, Brian F. Volkman, Francis C. Peterson, Christopher T. Veldkamp, Gertrud Malene Hjortø   +4 more
wiley   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, Volume 183, Issue 17, Page 5315-5335, September 2026.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source