Results 51 to 60 of about 37,262 (190)

Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]

, 2005
The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Becker, Peter, Eberharter, Anton, Ferreira, Roger   +2 more
core   +1 more source

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation [PDF]

ACS Chemical Biology, 2017
Histone acetyltransferases of the MYST family are recruited to chromatin by BRPF scaffolding proteins. We explored functional consequences and the therapeutic potential of inhibitors targeting acetyl-lysine dependent protein interaction domains (bromodomains) present in BRPF1-3 in bone maintenance.
Julia C. Meier, Cynthia Tallant, Oleg Fedorov, Hanna Witwicka, Sung-Yong Hwang, Ruud G. van Stiphout, Jean-Philippe Lambert, Catherine Rogers, Clarence Yapp, Brian S. Gerstenberger, Vita Fedele, Pavel Savitsky, David Heidenreich, Danette L. Daniels, Dafydd R. Owen, Paul V. Fish, Niall M. Igoe, Elliott D. Bayle, Bernard Haendler, Udo C.T. Oppermann, Francesca Buffa, Paul E. Brennan, Susanne Müller, Anne Claude Gingras, Paul R. Odgren, Mark J. Birnbaum, Stefan Knapp   +26 more
openaire   +4 more sources

Bromodomain: an acetyl‐lysine binding domain [PDF]

FEBS Letters, 2002
Bromodomains, an extensive family of evolutionarily conserved protein modules originally found in proteins associated with chromatin and in nearly all nuclear histone acetyltransferases, have been recently discovered to function as acetyl‐lysine binding domains.
Zeng, Lei, Zhou, Ming-Ming
openaire   +2 more sources

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation

Frontiers in Immunology, 2019
Group 2 innate lymphoid cells (ILC2) increase in frequency in eczema and allergic asthma patients, and thus represent a new therapeutic target cell for type-2 immune-mediated disease.
Bernhard Kerscher, Jillian L. Barlow, Batika M. Rana, Helen E. Jolin, Mayuri Gogoi, Michelle A. Bartholomew, Deepali Jhamb, Ashutosh Pandey, David F. Tough, Antoon J. M. van Oosterhout, Andrew N. J. McKenzie   +10 more
doaj   +1 more source

Development of a Novel Positron Emission Tomography (PET) Radiotracer Targeting Bromodomain and Extra-Terminal Domain (BET) Family Proteins

Frontiers in Molecular Biosciences, 2020
Bromodomain and extra-terminal domain (BET) family proteins have become a hot research area because of their close relationship with a variety of human diseases.
Ping Bai, Ping Bai, Ping Bai, Yu Lan, Hao Wang, Zude Chen, Stephanie Fiedler, Robin Striar, Xiaoxia Lu, Changning Wang   +9 more
doaj   +1 more source

Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome

Microbiology Spectrum, 2023
The eukaryotic protozoan parasite Trypanosoma brucei is transmitted by the tsetse fly to both humans and animals, where it causes a fatal disease called African trypanosomiasis.
Ethan C. Ashby, Jennifer L. Havens, Lindsey M. Rollosson, Johanna Hardin, Danae Schulz   +4 more
doaj   +1 more source

Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]

, 2017
Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana, Cippitelli, Marco, Fionda, Cinzia, Santoni, Angela, Soriani, Alessandra, Zingoni, Alessandra   +5 more
core   +1 more source

Progress in the development of non-​BET bromodomain chemical probes [PDF]

, 2016
The bromodomain and extra terminal (BET) family of bromodomains have been the focus of extensive research, leading to the development of many potent, selective chem. probes and recent clinical assets. The profound biol.
Arrowsmith, Bamborough, Bantscheff, Borah, Brand, Bunnage, Caron, Chaikuad, Chung, Chung, Chung, Chung, Clark, Coudé, Dawson, Demont, Demont, Drouin, Fedorov, Fedorov, Ferguson, Filippakopoulos, Filippakopoulos, Filippakopoulos, Fish, Furdas, Gallenkamp, Garnier, Gerona-Navarro, Gu, Guetzoyan, Harner, Hay, Hay, Hewings, Hewings, Hewings, Hohmann, Jennings, Knapp, Machleidt, McKeown, McLure, Medina, Mirguet, Mirguet, Mujtaba, Mujtaba, Mujtaba, Müller, Nicodeme, Philpott, Piatnitski Chekler, Picaud, Picaud, Prinjha, Rooney, Sachchidanand, Sanchez, Seal, Sweis, Sweis, Ullah, Vangamudi, Vidler, Werner, Zeng, Zhang   +67 more
core   +1 more source

Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

eLife, 2016
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression.
Andrew R Conery, Richard C Centore, Adrianne Neiss, Patricia J Keller, Shivangi Joshi, Kerry L Spillane, Peter Sandy, Charlie Hatton, Eneida Pardo, Laura Zawadzke, Archana Bommi-Reddy, Karen E Gascoigne, Barbara M Bryant, Jennifer A Mertz, Robert J Sims III   +14 more
doaj   +1 more source

Synthesis and Structure–Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research

Molecules, 2021
Epigenetic regulation is known to play a key role in progression of anti-cancer therapeutics. Lysine acetylation is an important mechanism in controlling gene expression.
Minjin Yoo, Tae Hyun Park, Miyoun Yoo, Yeongrin Kim, Joo-Youn Lee, Kyu Myung Lee, Seong Eon Ryu, Byung Il Lee, Kwan-Young Jung, Chi Hoon Park   +9 more
doaj   +1 more source