Results 201 to 210 of about 175,591 (354)

Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes

iMetaOmics, EarlyView.
Prmt5AKO downregulates genes related to fatty acid transport and triacylglycerol synthesis, while upregulating genes involved in glucose transport and cholesterol biogenesis. These changes cause alternation in lipid composition and metabolic phenotypes of Prmt5AKO mice. Abstract The adipose tissue (AT) is a main regulator of systemic energy homeostasis,
Xiyue Chen, Zhihao Jia, Xiashiyao Zhang, Feng Yue, James F. Markworth, Christina R. Ferreira, Jun Wan, Shihuan Kuang   +7 more
wiley   +1 more source

Imaging Brown Adipose Tissue: Current State and Future Perspective. [PDF]

Theranostics
Li J, Wang L, Wu S, Yang G, Zhang LJ.
europepmc   +1 more source

Brown adipose tissue: The magic bullet? [PDF]

Obesity, 2017
Patrick Schrauwen, Wouter D. van Marken Lichtenbelt   +1 more
openaire   +3 more sources

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue. [PDF]

Nat Commun
Sánchez-Feutrie M, Romero M, Veiga SR, Borràs-Ferré N, Berrow N, Ràfols M, Giménez N, Rodgers-Furones A, Sabaté-Pérez A, Rodríguez Pérez Á, Cataldo LR, Burghardt H, Sebastián D, Plana N, Hernández V, Alcaide LI, Reina Ó, Monte MJ, Marin JJG, Palacín M, Burcelin R, Antonson P, Gustafsson JA, Zorzano A.   +23 more
europepmc   +1 more source

Synthesis in vitro of rat brown adipose tissue 32000 M_r protein [PDF]

, 1983
Karl B. Freeman, Sing-Ming Chien, David W. Litchfield, Hasmukh V. Patel   +3 more
openalex   +1 more source

Regulation of Peripheral Molecular Clocks in Mammalian Tissues and In Vitro Skeletal Muscle Activation of AMP-Activated Protein Kinase via AICAR

, 2014
Most organisms possess a common molecular machinery that governs cellular and tissue circadian rhythmicity through a roughly 24-hour transcription-translation feedback loop.
Brandauer, Josef, Lupolt, Alex C., Moorhead, Daniel P.   +2 more
core  

Physiologically Based Pharmacokinetic Modeling of Oxcarbazepine to Characterize Its Disposition in Children with Obesity

The Journal of Clinical Pharmacology, EarlyView.
Abstract Oxcarbazepine (OXC) is a second‐generation antiseizure medication, effective through its active metabolite, 10‐mono‐hydroxy derivative (MHD). OXC is used as adjunctive therapy for focal‐onset and primary generalized tonic–clonic seizures, with recommended dosing based on age and body weight.
Patricia D. Maglalang, Jaydeep Sinha, Victόria Etges Helfer, Andrea Edginton, Kanecia Zimmerman, Chi Dang Hornik, William J. Muller, Mobeen Rathore, Daniel K. Benjamin Jr., Jia‐Yuh Chen, Ravinder Anand, Daniel Gonzalez, the Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee   +12 more
wiley   +1 more source

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang, Heng Fan, Qi Wang, Cheng‐Jie Jiang, Dan‐Hui Li, Ji‐Hui Ye   +5 more
wiley   +1 more source

Metabolic signals in sleep regulation: the role of brown adipose tissue. [PDF]

Neurobiol Sleep Circadian Rhythms
Szentirmai É, Kapás L.
europepmc   +1 more source