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Inflammatory Signaling and Brown Fat Activity [PDF]
Frontiers in Endocrinology, 2020 Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is known about the inflammatory status of brown adipose tissue (BAT) in ...
Farah Omran, Mark Christian
doaj +6 more sources
E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat [PDF]
EMBO ReportsThermogenic fat, including brown and beige fat, dissipates heat via thermogenesis and enhances energy expenditure. Thus, its activation represents a therapeutic strategy to combat obesity.
Jian Yu +24 more
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Dietary Fat Overload Reprograms Brown Fat Mitochondria [PDF]
Frontiers in Physiology, 2015 Chronic nutrient overload accelerates the onset of several aging-related diseases reducing life expectancy. Although the mechanisms by which overnutrition affects metabolic processes in many tissues are known, its role on BAT physiology is still unclear.
DANIELE eLETTIERI BARBATO +6 more
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Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders [PDF]
Diabetes & Metabolism Journal, 2016 Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the ...
So Hun Kim, Jorge Plutzky
doaj +2 more sources
Molecular Metabolism, 2019 Objective: Increasing the amounts of functionally competent brown adipose tissue (BAT) in adult humans has the potential to restore dysfunctional metabolism and counteract obesity.
Naja Z. Jespersen +15 more
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EPAC1 enhances brown fat growth and beige adipogenesis. [PDF]
Nat Cell BiolReverte-Salisa et al. show that, in preadipocytes, EPAC1 enhances brown adipose tissue growth and increases the function of thermogenic fat in obesogenic conditions.
Reverte-Salisa L +9 more
europepmc +2 more sources
Metabolic regulation and the anti-obesity perspectives of human brown fat
Redox Biology, 2017 Activation of brown adipose tissue (BAT) in adult humans increase glucose and fatty acid clearance as well as resting metabolic rate, whereas a prolonged elevation of BAT activity improves insulin sensitivity.
Camilla Scheele, Søren Nielsen
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Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice
Biomolecules, 2021 Increasing energy expenditure through activation of brown fat thermogenesis is a promising therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key player in regulating brown fat development and thermogenic program ...
Shirong Wang +7 more
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Brown-fat-mediated tumour suppression by cold-altered global metabolism
Nature, 2022 Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues1–6. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis2,7,8.
Takahiro Seki +15 more
semanticscholar +1 more source
Brown Fat Dnmt3b Deficiency Ameliorates Obesity in Female Mice
Life, 2021 Obesity results from a chronic energy imbalance due to energy intake exceeding energy expenditure. Activation of brown fat thermogenesis has been shown to combat obesity. Epigenetic regulation, including DNA methylation, has emerged as a key regulator of
Fenfen Li +6 more
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