Effect of Myostatin Gene Knockout on Browning of White Fat and Related Gene Expression Levels in a Mouse Model of Type 2 Diabetes Mellitus [PDF]
Zhongguo quanke yixue, 2022 Background The browning of white fat is a hot spot in metabolic disease research. Myostatin (Mstn) inhibits muscle growth, and has correlation with the growth and differentiation of adipocytes, but its effect on the browning of white fat in type 2 ...
Jingwei CHENG, Yangqing LIU, Yanfang WANG
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The brown fat-specific overexpression of RBP4 improves thermoregulation and systemic metabolism by activating the canonical adrenergic signaling pathway. [PDF]
Exp Mol MedPark JY +8 more
europepmc +3 more sources
Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity. [PDF]
PLoS ONE, 2012 Obesity is a major health problem worldwide. We are studying the causes and effects of obesity in C57Bl/6 mice following genetic ablation of NG2, a chondroitin sulfate proteoglycan widely expressed in progenitor cells and also in adipocytes.
Yunchao Chang +6 more
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Lipids in Health and Disease, 2020 Background Obesity is a metabolic imbalance characterized by excessive deposition of white fat. The browning of white fat can effectively treat obesity and related diseases.
Ju Zhang +8 more
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When brown fat sparked fire. [PDF]
Temperature (Austin)Jastroch M, Gaudry MJ.
europepmc +3 more sources
Temperature and species-dependent regulation of browning in retrobulbar fat
Scientific Reports, 2021 Retrobulbar fat deposits surround the posterior retina and optic nerve head, but their function and origin are obscure. We report that mouse retrobulbar fat is a neural crest-derived tissue histologically and transcriptionally resembles interscapular ...
Fatemeh Rajaii +6 more
doaj +1 more source
Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats. [PDF]
PLoS ONE, 2012 Previous evidence indicates that duodenal lipid sensing engages gut-brain neurocircuits to determine food intake and hepatic glucose production, but a potential role for gut-brain communication in the control of energy expenditure remains to be ...
Clémence Blouet, Gary J Schwartz
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Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity.
Journal of Clinical Investigation, 2020 BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown ...
Alana O'mara +26 more
semanticscholar +1 more source
Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice
Autophagy, 2020 Although macroautophagy/autophagy deficiency causes degenerative diseases, the deletion of essential autophagy genes in adipocytes paradoxically reduces body weight.
M. Ko +20 more
semanticscholar +1 more source