Results 21 to 30 of about 1,970,039 (250)

Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue’s Competence for Cold-Induced Thermogenic Recruitment

Frontiers in Endocrinology, 2020
Brown adipose tissue from mice living under conditions approaching human thermal and nutritional conditions (prolonged exposure to thermoneutral temperature and to an energy-rich (high-fat, high-sugar) diet) — referred to as “physiologically humanized ...
Alexander W. Fischer, Alexander W. Fischer, Jasper M. A. de Jong, Frederike Sass, Christian Schlein, Joerg Heeren, Natasa Petrovic   +6 more
doaj   +1 more source

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

Nature, 2019
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes.
T. Yoneshiro, Qiang Wang, Kazuki Tajima, Mami Matsushita, Hiroko Maki, Kaori Igarashi, Zhipeng Dai, P. White, R. McGarrah, O. Ilkayeva, Yann Deleye, Yasuo Oguri, Mito Kuroda, K. Ikeda, Huixia Li, Ayano Ueno, Maki Ohishi, Takamasa Ishikawa, Kyeongkyu Kim, Yong Chen, C. Sponton, R. Pradhan, Homa Majd, V. Greiner, Momoko Yoneshiro, Zachary Brown, M. Chondronikola, Haruya Takahashi, T. Goto, T. Kawada, L. Sidossis, F. Szoka, Michael T. McManus, M. Saito, T. Soga, S. Kajimura   +35 more
semanticscholar   +1 more source

PERAN LEMAK COKLAT DALAM MEKANISME PRODUKSI PANAS

Jurnal Berita Ilmu Keperawatan, 2008
Thermoregulation system have two process heat production, they are shivering and non shivering thermogenesis. Non shivering thermogenesis more happens in newborn human especially to adapt of low temperatures.
Siti Arifah, Kartinah Kartinah
doaj   +1 more source

Brown and beige fat: development, function and therapeutic potential

Nature Medicine, 2013
Patrick Seale
exaly   +2 more sources

TGF-beta/Smad3 signaling regulates brown adipocyte induction in white adipose tissue

Frontiers in Endocrinology, 2012
Recent identification of active brown fat reserves in adult humans has stimulated interest in the role of brown adipocytes in energy homeostasis. In addition, there is accumulating evidence to support the concept of an alteration in energy balance ...
Sushil G Rane, Hariom eYadav
doaj   +1 more source

Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment. [PDF]

PLoS ONE, 2009
BACKGROUND: Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, whereas white adipocytes are specialised in energy storage.
Maria Murholm, Karen Dixen, Klaus Qvortrup, Lillian H L Hansen, Ez-Zoubir Amri, Lise Madsen, Giorgio Barbatelli, Bjørn Quistorff, Jacob B Hansen   +8 more
doaj   +1 more source

DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice

Molecular Metabolism, 2023
Objectives: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth and metabolism. In mice, activation of mTOR controls cold adaptation by promoting the recruitment and the activation of brown adipose tissue (BAT ...
Charles Colas, Mathilde Mouchiroud, Manal Al Dow, Alona Kolnohuz, Yves Gélinas, Alexandre Caron, Mathieu Laplante   +6 more
doaj   +1 more source

Maternal High-Fructose Intake Activates Myogenic Program in Fetal Brown Fat and Predisposes Offspring to Diet-Induced Metabolic Dysfunctions in Adulthood

Frontiers in Nutrition, 2022
Excess dietary fructose intake is a major public health concern due to its deleterious effect to cause various metabolic and cardiovascular diseases. However, little is known about the effects of high-fructose consumption during pregnancy on offspring ...
Peng Wang, Tian Wu, Qinghua Fu, Qichao Liao, Yan Li, Tengda Huang, Yixing Li, Lei Zhou, Ziyi Song   +8 more
doaj   +1 more source

Derivation and characterization of a UCP1 reporter human ES cell line

Stem Cell Research, 2018
Interest in human brown fat as a novel therapeutic target to tackle the growing obesity and diabetes epidemic has increased dramatically in recent years.
Suranjit Mukherjee, Tuo Zhang, Lauretta A. Lacko, Lei Tan, Jenny Zhaoying Xiang, Jason M. Butler, Shuibing Chen   +6 more
doaj   +1 more source

The Engineering of Brown Fat [PDF]

Journal of Molecular Cell Biology, 2009
The developmental origins of brown adipose tissue and white adipose tissue are distinct, with brown adipocytes being derived from muscle precursors. PR domain containing 16, together with C/EBPbeta, forms a lineage-switching transcriptional complex which promotes brown fat differentiation and suppresses muscle cell differentiation.
Mark, Christian, Malcolm G, Parker
openaire   +2 more sources