Results 61 to 70 of about 18,811 (223)

Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin [PDF]

Journal of Virology, 2010
ABSTRACT Bone marrow stromal antigen 2 (BST-2/tetherin) is a cellular membrane protein that inhibits the release of HIV-1. We show for the first time, using infectious viruses, that BST-2 also inhibits egress of arenaviruses but has no effect on filovirus replication and spread.
Radoshitzky, Sheli R., Dong, Lian, Chi, Xiaoli, Clester, Jeremiah C., Retterer, Cary, Spurgers, Kevin, Kuhn, Jens H., Sandwick, Sarah, Ruthel, Gordon, Kota, Krishna, Boltz, Dutch, Warren, Travis, Kranzusch, Philip J., Whelan, Sean J., Bavari, Sina   +14 more
openaire   +3 more sources

Platform-based BST-2-targeted microbubbles enhance HIFU therapy and effectively inhibit prostate cancer residual growth

International Journal of Hyperthermia
Objective This study aims to evaluate the potential of BST2-targeted microbubble-facilitated HIFU therapy for prostate cancer (PCa), and to elucidate the mechanisms of synergistic tumor suppression in residual lesions.Methods The specificity of BST-2 ...
Hang Zhou, Jia Tang, Yujie Wan, Jiaqi Gong, Qizhi Wang, Kaifeng Huang, Ruixia Hong, Xinzhi Xu, Fang Li   +8 more
doaj   +1 more source

Epitope tags beside the N-terminal cytoplasmic tail of human BST-2 alter its intracellular trafficking and HIV-1 restriction.

PLoS ONE, 2014
BST-2 blocks the particle release of various enveloped viruses including HIV-1, and this antiviral activity is dependent on the topological arrangement of its four structural domains.
Mingyu Lv, Jiawen Wang, Jingyao Zhang, Biao Zhang, Xiaodan Wang, Yingzi Zhu, Tao Zuo, Donglai Liu, Xiaojun Li, Jiaxin Wu, Haihong Zhang, Bin Yu, Hui Wu, Xinghong Zhao, Wei Kong, Xianghui Yu   +15 more
doaj   +1 more source

2D Magnetic and Topological Quantum Materials and Devices for Ultralow Power Spintronics

Advanced Functional Materials, EarlyView.
2D magnets and topological quantum materials enable ultralow‐power spintronics by combining robust magnetic order with symmetry‐protected, Berry‐curvature‐driven transport. Fundamentals of 2D anisotropy and spin‐orbit‐coupling induced band inversion are linked to scalable growth and vdW stacking.
Brahmdutta Dixit, Yifei Yang, Shawn Li, Yu‐Chia Chen, Qi Jia, Jian‐Ping Wang   +5 more
wiley   +1 more source

The HIV-1 Vpu transmembrane domain topology and formation of a hydrophobic interface with BST-2 are critical for Vpu-mediated BST-2 downregulation [PDF]

, 2020
AbstractViruses belonging to the M group of human immunodeficiency virus (HIV-1) are the most virulent among the four HIV-1 groups. One factor that distinguishes the M group HIV-1 from others is Vpu, a membrane localized accessory protein, which promotes the release of virions by neutralizing the antiviral host cell protein BST-2.
Nabab Khan, Siladitya Padhi, Paresh Patel, U. Deva Priyakumar, Shahid Jameel   +4 more
openaire   +1 more source

Outcomes of Patients with Bacillus Calmette-Guérin (BCG)-Unresponsive Non-Muscle Invasive Bladder Cancer as Defined by the U.S. Food and Drug Administration

Bladder Cancer, 2022
BACKGROUND: Limited data are available on the outcomes of patients with non-muscle invasive bladder cancer (NMIBC) unresponsive to intravesical bacillus Calmette-Guérin (BCG), as defined by the United States Food and Drug Administration.
Jeffrey M. Howard, Grayden S. Cook, Aaron Tverye, Karabi Nandy, Vitaly Margulis, Solomon L. Woldu, Yair Lotan   +6 more
doaj   +1 more source

Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse

Advanced Science, EarlyView.
We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang, Yali Chang, Zibin Chu, Linghao Zhang, Tengfang Zhang, Dai Erhei, Xin Su, Zhe Yin   +7 more
wiley   +1 more source

Black soybean tempeh and purple sweet potato improve sperm quality in streptozotocin-induced diabetic rats [PDF]

Veterinary World, 2020
Background and Aim: Hyperglycemia increases advanced glycation end-product (AGE) production, and the activity of receptor for AGE (RAGE) in testis, which leads to testicular histopathological damage and infertility.
Abdul Gofur, Agung Witjoro, Siti Nur Arifah, Mochammad Fitri Atho'illah, Yuslinda Annisa, Sri Rahayu Lestari   +5 more
doaj   +1 more source

An ATP‐Mediated Antibiotic β‐Peptide Nanofiber That Kills Multidrug‐Resistant Bacteria via a Multistage Mechanism

Advanced Science, EarlyView.
The 3K‐AP system forms infinite supramolecular fibrils that undergo controlled degradation into shorter fragments upon enzymatic hydrolysis. Multitechnique imaging reveals a stepwise bacteriolytic mechanism involving bacterial entrapment, disassembly into lethal constructs, and associated extracellular vesicle release, highlighting the dynamic ...
Sohini Chakraborty, Kamal el Battioui, Dániel Molnár, Bálint Jezsó, Lejla Daruka, Tasvilla Sonallya, Tünde Juhász, Rita Hirmondó, Imola Cs. Szigyártó, Loránd Románszki, Natália Tőkési, Daniel Pinkas, Eszter Házy, Olivér Pavela, Andrea Bodor, Zoltán Varga, István Mándity, Mihály Kovács, Csaba Pál, Kata Horváti, Judit Tóth, Tamás Beke‐Somfai   +21 more
wiley   +1 more source

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin. [PDF]

, 2016
Tetherin (BST2/CD317) is a viral restriction factor that anchors enveloped viruses to host cells and limits viral spread. The HIV-1 Vpu accessory protein counteracts tetherin by decreasing its cell surface expression and targeting it for ubiquitin ...
Davis, Luther J, Lehner, Paul J, Paul Luzio, J, Rapiteanu, Radu, Timms, Richard T, Williamson, James C   +5 more
core   +2 more sources