Results 91 to 100 of about 1,353,755 (237)

Bioadhesive Buccal Delivery Systems

The buccal route offers a viable alternative to conventional drug delivery methods by enabling non-invasive administration, circumventing hepatic first-pass metabolism, and improving patient adherence.
Abdulhussain, Rand, Adebisi, Adeola O.; id_orcid, Asare-Addo, Kofi, Ghazali, Yusuf O.   +3 more
core   +1 more source

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

Movement Disorders, EarlyView.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky   +6 more
wiley   +1 more source

Body Size, Dental Pathology, and Maternal Genetic Diversity of Ancient Horses in the Eastern Baltic Sea Region and Western Russia

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT The early evolutionary history of modern domestic horses (Equus caballus/Equus ferus caballus), known as the DOM2 lineage, is well documented due to numerous archaeological and ancient DNA (aDNA) studies. Although many uncertainties remain in the domestication timeline, current evidence suggests that the domestication of modern horses began in
Johanna Honka, Daniela Salazar, Arthur O. Askeyev, Igor V. Askeyev, Oleg V. Askeyev, Jouni Aspi, Gulshat Sh. Asylgaraeva, Markku Niskanen, Kristiina Mannermaa, Suvi Olli, Noora Piipponen, Giedrė Piličiauskienė, Dilyara N. Shaymuratova, Renat R. Valiev, Laura Kvist   +14 more
wiley   +1 more source

A Review on study of Buccal Drug Delivery System [PDF]

, 2011
Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules. However,
ANGURE, SHRIPAL, MUJORIYA, RAJESH, DHAMANDE, KISHOR, WANKHEDE, UTPAL RAJ   +3 more
core   +1 more source

Congenital Intraoral Synechiae: A Scoping Review of Airway, Feeding, and Surgical Management

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To map the existing literature on congenital intraoral synechiae and summarize reported anatomic patterns, clinical presentation, associated anomalies/syndromes, and outcomes to inform standardized diagnostic and therapeutic approaches. Data Sources PubMed, CINAHL, Embase, Web of Science, and Google Scholar were searched from January
Jason Bernier, Mathieu Bergeron
wiley   +1 more source

The efficacy of concurrent chemoradiotherapy with or without nimotuzumab in high‐risk patients with locally advanced head and neck squamous cell carcinoma post‐surgery: A real‐world study

Precision Radiation Oncology, EarlyView.
Figure 1 Patient selection flowchart. CCRT, concurrent chemoradiotherapy; NCCRT, nimotuzumab and concurrent chemoradiotherapy. Abstract Purpose Patients with locally advanced head and neck squamous cell carcinoma (LA‐HNSCC) harboring high‐risk pathological features after radical surgery face high recurrence rates.
Yuejia Zhou, Linting Zhang, Wenjuan Lai, Jingyun Tan, Jing Gao, Yajie Liu, Shubin Wang, Feng Peng, Gangling Tong   +8 more
wiley   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

The morphological affinities of the fossil cranium from Kabua, Kenya Affinités morphologiques du crâne fossile de Kabua (Kenya)

Journal of the Royal Anthropological Institute, EarlyView.
Our current understanding of the origins of Homo sapiens is limited, in part, by the fragmented fossil record from Late Pleistocene and early Holocene Africa. Here, we re‐examine the Kabua 1 cranium, an enigmatic and little‐studied Kenyan fossil discovered in the 1950s. We compare virtual reconstructions created previously by our team with a wide range
Abel Marinus Bosman, Laura Tabitha Buck, Hugo Reyes‐Centeno, Marta Mirazón Lahr, Chris Stringer, Rainer Grün, Qingfeng Shao, Katerina Harvati   +7 more
wiley   +1 more source

Mucoadhesive Buccal Patches Containing Resveratrol and/or Erythromycin-Loaded Lipid Microparticles as a Potential Targeted Strategy for the Prevention and Management of MRONJ in Patients Undergoing Oral Surgery

Antibiotics
Background/Objectives: Oral surgical procedures in patients at risk of/diagnosed with MRONJ require systemic antibiotic therapy, which can fail to achieve an adequate local drug concentration.
Giulia Di Prima, Cecilia La Mantia, Giada Tranchida, Alessandro Presentato, Giovanna Giuliana, Giuseppina Campisi, Viviana De Caro   +6 more
doaj   +1 more source

Nicotine pouches and clinical outcomes related to smoking cessation: A systematic review of randomized trials

Addiction, EarlyView.
Abstract Background and aims Tobacco‐free nicotine pouches (NPs) are oral nicotine products promoted by manufacturers and some researchers as tools that may reduce nicotine cravings and support smoking reduction or cessation. However, evidence regarding their actual clinical impact remains limited.
Javad Heshmati, Spencer Shahen, Emma Lynn Bates, Sarah Visintini, Evyanne Quirouette, Kerri‐Anne Mullen, Hassan Mir   +6 more
wiley   +1 more source