Results 61 to 70 of about 1,353,755 (237)

Buccal and sublingual vaccine delivery [PDF]

, 2014
Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination. An important characteristic of mucosal vaccination is its ability to elicit local immune responses, which ...
Kraan, Heleen, Kersten, Gideon, Vrieling, Hilde, Amorij, Jean-Pierre, Jiskoot, Wim, Czerkinsky, Cecil   +5 more
core   +1 more source

Acute toxic leucoencephalopathy following protonitazene ingestion

British Journal of Clinical Pharmacology, EarlyView.
Background Distribution of illicit counterfeit alprazolam containing the highly potent synthetic opioid‐receptor agonist protonitazene recently resulted in a number of severe overdoses in Ireland. We report three cases that presented to our hospital, within 6 weeks of one another, following ingestion of illicitly‐sourced alprazolam.
Ruadhan O'Laoi, Holly Acton, Pierce Kavanagh, Isabelle Hunt, Niall Sheehy, Cormac Kennedy   +5 more
wiley   +1 more source

Examination of Effective Buccal Absorption of Salmon Calcitonin Using Cell-Penetrating Peptide-Conjugated Liposomal Drug Delivery System

International Journal of Nanomedicine, 2022
Taekwang Keum,1,2,* Gyubin Noh,1,2,* Jo-Eun Seo,1 Santosh Bashyal,1,2 Dong Hwan Sohn,1 Sangkil Lee1,2 1College of Pharmacy, Keimyung University, Daegu, Republic of Korea; 2Center for Forensic Pharmaceutical Science, Daegu, Republic of Korea&ast ...
Keum T, Noh G, Seo JE, Bashyal S, Sohn DH, Lee S   +5 more
doaj  

Optimized micro‐sized cell sphere‐matrix niche co‐aggregates promote efficient oral and craniomaxillofacial bone regeneration

BMEMat, EarlyView.
The construct of cell‐niche co‐aggregates (GelMA‐SHED sphere‐DDMPs) promotes cranial and periodontal bone regeneration and ensures angiogenic‐osteogenic coupling by downregulating miR‐34c‐5p to enhance the expression of NOTCH1 and its intracellular domain (NICD).
Xiao‐Hui Zhang, Shi‐Han Mu, Yi‐Han Xiao, Lu‐Fan Yang, Peng‐Fei Wang, Teng‐Fei Hu, Jun‐Xi He, Jiong‐Zhen Piao, Sha Zhang, Jin‐Yu Liu, Yi‐De He, Ying‐Ying Wu, Si‐Qi Ying, Xin‐Yue Cai, Chen‐Han Li, Zi‐Qi Zhang, Xiao Lei, Ji Chen, Jian‐Fei Liang, Yan Jin, Bing‐Dong Sui, Chao Ma, Chen‐Xi Zheng, Fang Jin   +23 more
wiley   +1 more source

Applications of β-limit Dextrin as a Matrix Forming Excipient for Fast Disintegrating Buccal Dosage Formats

Journal of Pharmacy & Pharmaceutical Sciences, 2013
- Purpose. To compare the properties of buccal delivery matrices (wafers) made with dextrin, β-limit dextrin and pre-gelatinised starch. Methods. The constituent α-glucans were tested for their mucoadhesive properties in solution plus their content of ...
Xin Qi, Richard Tester, Yu Liu, Margaret Mullin   +3 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Ten‐year follow‐up of bilateral gingival recession treatment: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background This work aims to present a 10‐year follow‐up of a young patient who underwent treatment with collagen matrix (CM) combined with enamel matrix derivative (EMD) for bilateral gingival recessions in the maxillary canine region. Methods The patient, a 25‐year‐old woman, presented with bilateral Cairo type 1 recessions.
Luiz C. L. Marques‐Junior, Milena S. Irie, Edgar Daniel Vargas‐Quiroga, Mario Taba‐Jr, Atila V. V. Nobre   +4 more
wiley   +1 more source

A microneedle platform for buccal macromolecule delivery

, 2021
© 2021 American Association for the Advancement of Science. All rights reserved. Alternative means for drug delivery are needed to facilitate drug adherence and administration.
Fujimoto, James, Jessica Wong, Siddartha Tamang, Soyoung Kim, Alison Hayward, Raissa Yona, Yoshitake, Tadayuki, Vance Soares, Giovanni Traverso, Shane McDonnell, Collins, Joy, Wong, Jessica, Rebecca McManus, Vegge, Andreas, František Hubálek, Hayward, Alison, Wainer, Jacob, Frederiksen, Morten Revsgaard, Kim, Soyoung, Soares, Vance, Langer, Robert, Liu, Xiewen, Daniel Minahan, Joy Collins, Morten Revsgaard Frederiksen, Fels, Johannes, Tamang, Siddartha, Minahan, Daniel, Hubálek, František, Traverso, Giovanni, Fauziah R. Zakaria, Rahbek, Ulrik, Niclas Roxhed, Sarah R. Stern, Lu, Xiaoya, James Fujimoto, Zakaria, Fauziah R, McManus, Rebecca, Roxhed, Niclas, Caffarel-Salvador, Ester, Stern, Sarah R, Ulrik Rahbek, Ryan Yu Tian, Ester Caffarel-Salvador, Xiewen Liu, Ishida, Keiko, Tian, Ryan Yu, Jacob Wainer, Robert Langer, Tadayuki Yoshitake, Keiko Ishida, Johannes Fels, Andreas Vegge, Yona, Raissa, Xiaoya Lu, McDonnell, Shane   +55 more
core   +1 more source

Simplified SPAL technique to provide adequate peri‐implant phenotype: A pilot study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Correction of peri‐implant bone dehiscence (PIBD) and optimization of the peri‐implant soft‐tissue phenotype are critical for long‐term peri‐implant tissues stability. A simplified, one‐stage, transmucosal variant of the subperiosteal peri‐implant augmented layer (sSPAL) technique was appraised and evaluated.
Leonardo Trombelli, Chiara Franzini, Mattia Severi   +2 more
wiley   +1 more source

Guided bone regeneration using titanium mesh and xenogeneic graft alone: Histologic findings and 7‐year follow‐up

Clinical Advances in Periodontics, EarlyView.
Abstract Background Guided bone regeneration is a reliable technique for treating alveolar ridge deficiencies, especially in cases of severe maxillary atrophy. This case report describes the clinical management of a partially edentulous female patient presenting horizontal bone resorption in the anterior maxilla.
Bruno Freitas Mello, Maria Eduarda Bernardo, Gustavo dos Santos Coura, Márcio de Carvalho Formiga   +3 more
wiley   +1 more source