Results 51 to 60 of about 106,461 (152)
Green Chemistry Letters and ReviewsTetrahydroisoquinolines (THIQs) are a significant class of nitrogen-containing heterocyclic compounds often occurring in natural products and pharmaceuticals, exhibiting excellent biological activities and chemical properties, and also having a wide ...
Kai Yang +5 more
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iScience, 2020 Summary: Functionalization of α-C–H bonds of tertiary amines to build various α-C–X bonds has become a mainstream in synthetic chemistry nowadays. However, due to lack of fundamental knowledge on α-C–H bond strength as an energetic guideline, rational ...
Wenzhi Luo, Jin-Dong Yang, Jin-Pei Cheng
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Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles
Nature Communications, 2021 Late-stage C(sp3)-H bond functionalization of N-heterocycles with broad substrate scope remains a challenge and of particular significance to modern chemical synthesis and pharmaceutical chemistry. Here the authors show copper-catalysed late-stage C(sp3)-
Zhe Chang +6 more
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Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis [PDF]
, 2019 A major challenge in carbon‒hydrogen (C‒H) bond functionalization is to have the catalyst control precisely where a reaction takes place. Here we report engineered cytochrome P450 enzymes that perform unprecedented enantioselective C‒H amidation ...
Arnold, Frances H. +2 more
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Osmium-mediated direct C–H bond activation at the 8-position of quinolines [PDF]
, 2016 Metal-mediated direct C–H bond activation at the 8-position of quinolines, which is the essential step for the functionalization of this bond, is promoted by the hexahydride OsH6(PiPr3)2.
Esteruelas, Miguel A. +2 more
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Recent developments in photoredox-catalyzed remote ortho and para C–H bond functionalizations
Beilstein Journal of Organic Chemistry, 2020 In recent years, the research area of direct C–H bond functionalizations was growing exponentially not only due to the ubiquity of inert C–H bonds in diverse organic compounds, including bioactive natural and nonnatural products, but also due to its ...
Rafia Siddiqui, Rashid Ali
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Bromophenyl functionalization of carbon nanotubes : an ab initio study [PDF]
, 2012 We study the thermodynamics of bromophenyl functionalization of carbon nanotubes with respect to diameter and metallic/insulating character using density-functional theory (DFT).
Beaudin, Jason +4 more
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Pyridine C(sp2)–H bond functionalization under transition-metal and rare earth metal catalysis
Beilstein Journal of Organic Chemistry, 2023 Pyridine is a crucial heterocyclic scaffold that is widely found in organic chemistry, medicines, natural products, and functional materials. In spite of the discovery of several methods for the synthesis of functionalized pyridines or their integration ...
Haritha Sindhe +6 more
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Nature Communications, 2019 Direct α-functionalization of acetonitrile, a bulk chemical, is usually limited to its enolate chemistry. Here, the authors show an electro-oxidative C(sp3)–H bond functionalization of acetonitrile with thiols to afford tetrasubstituted olefins with high
Tian-Jun He +3 more
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[2,2′-Bipyridin]-6(1H)-one, a Truly Cooperating Ligand in the Palladium-Mediated C–H Activation Step: Experimental Evidence in the Direct C-3 Arylation of Pyridine [PDF]
, 2018 Producción CientíficaThe ligand [2,2′-bipyridin]-6(1H)-one (bipy-6-OH) has a strong accelerating effect on the Pd- catalyzed direct arylation of pyridine or arenes.
Albéniz Jiménez, Ana Carmen +2 more
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