Results 41 to 50 of about 31,021,495 (194)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Valutazione dell'effetto di trattamenti termici tecnologici ed enzimatici sulla concentrazione di ginkotossina in semi di Ginkgo Biloba L. [PDF]

, 2021
La pianta Ginkgo biloba L. è nota da secoli per le sue proprietà benefiche. Gli estratti delle foglie sono infatti impiegati in numerosi Paesi come ingredienti di integratori alimentari per coadiuvare la sintomatologia associata a diverse condizioni ...
C. Di Lorenzo, S. Biella, C. Bani, P. Restani   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A network of acetyl phosphate-dependent modification modulates c-di-AMP homeostasis in Actinobacteria

mBio
Cyclic purine nucleotides are important signal transduction molecules across all domains of life. 3′,5′-cyclic di-adenosine monophosphate (c-di-AMP) has roles in both prokaryotes and eukaryotes, while the signals that adjust intracellular c-di-AMP and ...
Yu Fu, Liu-Chang Zhao, Jin-Long Shen, Shi-Yu Zhou, Bin-Cheng Yin, Bang-Ce Ye, Di You   +6 more
doaj   +1 more source

Intracellular Concentrations of Borrelia burgdorferi Cyclic Di-AMP Are Not Changed by Altered Expression of the CdaA Synthase. [PDF]

PLoS ONE, 2015
The second messenger nucleotide cyclic diadenylate monophosphate (c-di-AMP) has been identified in several species of Gram positive bacteria and Chlamydia trachomatis. This molecule has been associated with bacterial cell division, cell wall biosynthesis
Christina R Savage, William K Arnold, Alexandra Gjevre-Nail, Benjamin J Koestler, Eric L Bruger, Jeffrey R Barker, Christopher M Waters, Brian Stevenson   +7 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis

mBio, 2021
The bacterial second messenger cyclic di-AMP (c-di-AMP) is a global regulator of potassium homeostasis and compatible solute uptake in many Gram-positive bacteria, making it essential for osmoregulation.
Huong Thi Pham, Wen Shi, Yuwei Xiang, Su Yi Foo, Manuel R. Plan, Pascal Courtin, Marie-Pierre Chapot-Chartier, Eddy J. Smid, Zhao-Xun Liang, Esteban Marcellin, Mark S. Turner   +10 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Allosteric regulation by c-di-AMP modulates a complete N-acetylglucosamine signaling cascade in Saccharopolyspora erythraea

Nature Communications
c-di-AMP is an essential and widespread nucleotide second messenger in bacterial signaling. For most c-di-AMP synthesizing organisms, c-di-AMP homeostasis and the molecular mechanisms pertaining to its signal transduction are of great concern.
Di You, Liu-Chang Zhao, Yu Fu, Zhi-Yao Peng, Zong-Qin Chen, Bang-Ce Ye   +5 more
doaj   +1 more source

Cyclic di-AMP traps proton-coupled K+ transporters of the KUP family in an inward-occluded conformation

Nature Communications, 2023
Cyclic di-AMP is the only known essential second messenger in bacteria and archaea, regulating different proteins indispensable for numerous physiological processes.
Michael F. Fuss, Jan-Philip Wieferig, Robin A. Corey, Yvonne Hellmich, Igor Tascón, Joana S. Sousa, Phillip J. Stansfeld, Janet Vonck, Inga Hänelt   +8 more
doaj   +1 more source